Systemic review and meta-analysis of diagnostic efficacy of fractional flow reserve using computed tomography angiography for first-time diagnosis of coronary artery disease
Coronary artery disease is a leading global cause of mortality. It can be diagnosed by fractional flow reserve (FFR) estimation using computed tomography (CT) angiography. This systematic review aims to review the literature about the diagnostic efficacy of FFR estimation using CT scan (FFR-CT) for...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2018-01-01
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| Series: | Research in Cardiovascular Medicine |
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| Online Access: | http://www.rcvmonline.com/article.asp?issn=2251-9572;year=2018;volume=7;issue=4;spage=159;epage=164;aulast=Kumar |
| _version_ | 1818512487347126272 |
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| author | Narendra Kumar Ajay Kumar Sinha Pramod Kumar Arun Kumar Jha Karuppiah Arunachalam Sanjeev Kumar Ahmad Zakariya Shaimaa Mostafa |
| author_facet | Narendra Kumar Ajay Kumar Sinha Pramod Kumar Arun Kumar Jha Karuppiah Arunachalam Sanjeev Kumar Ahmad Zakariya Shaimaa Mostafa |
| author_sort | Narendra Kumar |
| collection | DOAJ |
| description | Coronary artery disease is a leading global cause of mortality. It can be diagnosed by fractional flow reserve (FFR) estimation using computed tomography (CT) angiography. This systematic review aims to review the literature about the diagnostic efficacy of FFR estimation using CT scan (FFR-CT) for the diagnosis of coronary artery disease. The dual databases of Medline and Cochrane Central Register of Controlled Trials were searched for relevant literature from their inception till August 15, 2017. The methodological quality was assessed using the Cochrane risk of bias tool. Pooled estimates of specificity and sensitivity were assessed with the corresponding 95% confidence intervals (CI). After careful screening, five studies involving a total of 296 patients were included in the study. For FFR-CT, on meta-analysis of the pooled risk ratio per patient, random-effects model value was 3.79 (95% CI, 2.93–4.90) and odds ratio per patient was 11.78 (95% CI, 8.08–17.17). The odds ratio by year to see if heterogeneity is due to sample size was 2.50 (95% CI, 1.06–5.91). FFR-CT appears to be a reliable and efficacious noninvasive imaging modality, as it demonstrates high accuracy in the determination of anatomy and lesion-specific ischemia, which justifies the performance of additional randomized controlled trials to evaluate the clinical benefits of FFR-CT-guided coronary revascularization. |
| first_indexed | 2024-12-10T23:47:34Z |
| format | Article |
| id | doaj.art-a6a5de2c4ade428d96eb4a9a96ae2533 |
| institution | Directory Open Access Journal |
| issn | 2251-9572 2251-9580 |
| language | English |
| last_indexed | 2024-12-10T23:47:34Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Research in Cardiovascular Medicine |
| spelling | doaj.art-a6a5de2c4ade428d96eb4a9a96ae25332022-12-22T01:28:53ZengWolters Kluwer Medknow PublicationsResearch in Cardiovascular Medicine2251-95722251-95802018-01-017415916410.4103/rcm.rcm_28_18Systemic review and meta-analysis of diagnostic efficacy of fractional flow reserve using computed tomography angiography for first-time diagnosis of coronary artery diseaseNarendra KumarAjay Kumar SinhaPramod KumarArun Kumar JhaKaruppiah ArunachalamSanjeev KumarAhmad ZakariyaShaimaa MostafaCoronary artery disease is a leading global cause of mortality. It can be diagnosed by fractional flow reserve (FFR) estimation using computed tomography (CT) angiography. This systematic review aims to review the literature about the diagnostic efficacy of FFR estimation using CT scan (FFR-CT) for the diagnosis of coronary artery disease. The dual databases of Medline and Cochrane Central Register of Controlled Trials were searched for relevant literature from their inception till August 15, 2017. The methodological quality was assessed using the Cochrane risk of bias tool. Pooled estimates of specificity and sensitivity were assessed with the corresponding 95% confidence intervals (CI). After careful screening, five studies involving a total of 296 patients were included in the study. For FFR-CT, on meta-analysis of the pooled risk ratio per patient, random-effects model value was 3.79 (95% CI, 2.93–4.90) and odds ratio per patient was 11.78 (95% CI, 8.08–17.17). The odds ratio by year to see if heterogeneity is due to sample size was 2.50 (95% CI, 1.06–5.91). FFR-CT appears to be a reliable and efficacious noninvasive imaging modality, as it demonstrates high accuracy in the determination of anatomy and lesion-specific ischemia, which justifies the performance of additional randomized controlled trials to evaluate the clinical benefits of FFR-CT-guided coronary revascularization.http://www.rcvmonline.com/article.asp?issn=2251-9572;year=2018;volume=7;issue=4;spage=159;epage=164;aulast=KumarAngiographycomputed tomographycomputed tomography-fractional flow reservecoronary artery diseasefractional flow reserve |
| spellingShingle | Narendra Kumar Ajay Kumar Sinha Pramod Kumar Arun Kumar Jha Karuppiah Arunachalam Sanjeev Kumar Ahmad Zakariya Shaimaa Mostafa Systemic review and meta-analysis of diagnostic efficacy of fractional flow reserve using computed tomography angiography for first-time diagnosis of coronary artery disease Research in Cardiovascular Medicine Angiography computed tomography computed tomography-fractional flow reserve coronary artery disease fractional flow reserve |
| title | Systemic review and meta-analysis of diagnostic efficacy of fractional flow reserve using computed tomography angiography for first-time diagnosis of coronary artery disease |
| title_full | Systemic review and meta-analysis of diagnostic efficacy of fractional flow reserve using computed tomography angiography for first-time diagnosis of coronary artery disease |
| title_fullStr | Systemic review and meta-analysis of diagnostic efficacy of fractional flow reserve using computed tomography angiography for first-time diagnosis of coronary artery disease |
| title_full_unstemmed | Systemic review and meta-analysis of diagnostic efficacy of fractional flow reserve using computed tomography angiography for first-time diagnosis of coronary artery disease |
| title_short | Systemic review and meta-analysis of diagnostic efficacy of fractional flow reserve using computed tomography angiography for first-time diagnosis of coronary artery disease |
| title_sort | systemic review and meta analysis of diagnostic efficacy of fractional flow reserve using computed tomography angiography for first time diagnosis of coronary artery disease |
| topic | Angiography computed tomography computed tomography-fractional flow reserve coronary artery disease fractional flow reserve |
| url | http://www.rcvmonline.com/article.asp?issn=2251-9572;year=2018;volume=7;issue=4;spage=159;epage=164;aulast=Kumar |
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