Near-infrared fluorescent probes for imaging of amyloid plaques in Alzheimer׳s disease
One of the early pathological hallmarks of Alzheimer׳s disease (AD) is the deposition of amyloid-β (Aβ) plaques in the brain. There has been a tremendous interest in the development of Aβ plaques imaging probes for early diagnosis of AD in the past decades. Optical imaging, particularly near-infrare...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2015-01-01
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| Series: | Acta Pharmaceutica Sinica B |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211383514001270 |
| _version_ | 1811343294642257920 |
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| author | Hongjuan Tong Kaiyan Lou Wei Wang |
| author_facet | Hongjuan Tong Kaiyan Lou Wei Wang |
| author_sort | Hongjuan Tong |
| collection | DOAJ |
| description | One of the early pathological hallmarks of Alzheimer׳s disease (AD) is the deposition of amyloid-β (Aβ) plaques in the brain. There has been a tremendous interest in the development of Aβ plaques imaging probes for early diagnosis of AD in the past decades. Optical imaging, particularly near-infrared fluorescence (NIRF) imaging, has emerged as a safe, low cost, real-time, and widely available technique, providing an attractive approach for in vivo detection of Aβ plaques among many different imaging techniques. In this review, we provide a brief overview of the state-of-the-art development of NIRF Aβ probes and their in vitro and in vivo applications with special focus on design strategies and optical, binding, and brain-kinetic properties. |
| first_indexed | 2024-04-13T19:27:01Z |
| format | Article |
| id | doaj.art-a6a65d32f1c24ffda99bdf1659f8f599 |
| institution | Directory Open Access Journal |
| issn | 2211-3835 2211-3843 |
| language | English |
| last_indexed | 2024-04-13T19:27:01Z |
| publishDate | 2015-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Acta Pharmaceutica Sinica B |
| spelling | doaj.art-a6a65d32f1c24ffda99bdf1659f8f5992022-12-22T02:33:20ZengElsevierActa Pharmaceutica Sinica B2211-38352211-38432015-01-0151253310.1016/j.apsb.2014.12.006Near-infrared fluorescent probes for imaging of amyloid plaques in Alzheimer׳s diseaseHongjuan Tong0Kaiyan Lou1Wei Wang2Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, State Key Laboratory of Bioengineering Reactor, East China University of Science and Technology, Shanghai 200237, ChinaShanghai Key Laboratory of Chemical Biology, School of Pharmacy, State Key Laboratory of Bioengineering Reactor, East China University of Science and Technology, Shanghai 200237, ChinaShanghai Key Laboratory of Chemical Biology, School of Pharmacy, State Key Laboratory of Bioengineering Reactor, East China University of Science and Technology, Shanghai 200237, ChinaOne of the early pathological hallmarks of Alzheimer׳s disease (AD) is the deposition of amyloid-β (Aβ) plaques in the brain. There has been a tremendous interest in the development of Aβ plaques imaging probes for early diagnosis of AD in the past decades. Optical imaging, particularly near-infrared fluorescence (NIRF) imaging, has emerged as a safe, low cost, real-time, and widely available technique, providing an attractive approach for in vivo detection of Aβ plaques among many different imaging techniques. In this review, we provide a brief overview of the state-of-the-art development of NIRF Aβ probes and their in vitro and in vivo applications with special focus on design strategies and optical, binding, and brain-kinetic properties.http://www.sciencedirect.com/science/article/pii/S2211383514001270Alzheimer׳s diseaseBlood-brain barrierFluorescence probeNear-infrared fluorescenceOptical imagingAmyloid-β plagues |
| spellingShingle | Hongjuan Tong Kaiyan Lou Wei Wang Near-infrared fluorescent probes for imaging of amyloid plaques in Alzheimer׳s disease Acta Pharmaceutica Sinica B Alzheimer׳s disease Blood-brain barrier Fluorescence probe Near-infrared fluorescence Optical imaging Amyloid-β plagues |
| title | Near-infrared fluorescent probes for imaging of amyloid plaques in Alzheimer׳s disease |
| title_full | Near-infrared fluorescent probes for imaging of amyloid plaques in Alzheimer׳s disease |
| title_fullStr | Near-infrared fluorescent probes for imaging of amyloid plaques in Alzheimer׳s disease |
| title_full_unstemmed | Near-infrared fluorescent probes for imaging of amyloid plaques in Alzheimer׳s disease |
| title_short | Near-infrared fluorescent probes for imaging of amyloid plaques in Alzheimer׳s disease |
| title_sort | near infrared fluorescent probes for imaging of amyloid plaques in alzheimer׳s disease |
| topic | Alzheimer׳s disease Blood-brain barrier Fluorescence probe Near-infrared fluorescence Optical imaging Amyloid-β plagues |
| url | http://www.sciencedirect.com/science/article/pii/S2211383514001270 |
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