Unveiling the Associations between EEG Indices and Cognitive Deficits in Schizophrenia-Spectrum Disorders: A Systematic Review
Cognitive dysfunctions represent a core feature of schizophrenia-spectrum disorders due to their presence throughout different illness stages and their impact on functioning. Abnormalities in electrophysiology (EEG) measures are highly related to these impairments, but the use of EEG indices in clin...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-09-01
|
| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/12/9/2193 |
| _version_ | 1797489413996937216 |
|---|---|
| author | Andrea Perrottelli Giulia Maria Giordano Francesco Brando Luigi Giuliani Pasquale Pezzella Armida Mucci Silvana Galderisi |
| author_facet | Andrea Perrottelli Giulia Maria Giordano Francesco Brando Luigi Giuliani Pasquale Pezzella Armida Mucci Silvana Galderisi |
| author_sort | Andrea Perrottelli |
| collection | DOAJ |
| description | Cognitive dysfunctions represent a core feature of schizophrenia-spectrum disorders due to their presence throughout different illness stages and their impact on functioning. Abnormalities in electrophysiology (EEG) measures are highly related to these impairments, but the use of EEG indices in clinical practice is still limited. A systematic review of articles using Pubmed, Scopus and PsychINFO was undertaken in November 2021 to provide an overview of the relationships between EEG indices and cognitive impairment in schizophrenia-spectrum disorders. Out of 2433 screened records, 135 studies were included in a qualitative review. Although the results were heterogeneous, some significant correlations were identified. In particular, abnormalities in alpha, theta and gamma activity, as well as in MMN and P300, were associated with impairments in cognitive domains such as attention, working memory, visual and verbal learning and executive functioning during at-risk mental states, early and chronic stages of schizophrenia-spectrum disorders. The review suggests that machine learning approaches together with a careful selection of validated EEG and cognitive indices and characterization of clinical phenotypes might contribute to increase the use of EEG-based measures in clinical settings. |
| first_indexed | 2024-03-10T00:17:12Z |
| format | Article |
| id | doaj.art-a6a89d942b9740b9a93500a1548cbfbf |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T00:17:12Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-a6a89d942b9740b9a93500a1548cbfbf2023-11-23T15:50:14ZengMDPI AGDiagnostics2075-44182022-09-01129219310.3390/diagnostics12092193Unveiling the Associations between EEG Indices and Cognitive Deficits in Schizophrenia-Spectrum Disorders: A Systematic ReviewAndrea Perrottelli0Giulia Maria Giordano1Francesco Brando2Luigi Giuliani3Pasquale Pezzella4Armida Mucci5Silvana Galderisi6Department of Psychiatry, University of Campania “Luigi Vanvitelli”, Largo Madonna delle Grazie 1, 80138 Naples, ItalyDepartment of Psychiatry, University of Campania “Luigi Vanvitelli”, Largo Madonna delle Grazie 1, 80138 Naples, ItalyDepartment of Psychiatry, University of Campania “Luigi Vanvitelli”, Largo Madonna delle Grazie 1, 80138 Naples, ItalyDepartment of Psychiatry, University of Campania “Luigi Vanvitelli”, Largo Madonna delle Grazie 1, 80138 Naples, ItalyDepartment of Psychiatry, University of Campania “Luigi Vanvitelli”, Largo Madonna delle Grazie 1, 80138 Naples, ItalyDepartment of Psychiatry, University of Campania “Luigi Vanvitelli”, Largo Madonna delle Grazie 1, 80138 Naples, ItalyDepartment of Psychiatry, University of Campania “Luigi Vanvitelli”, Largo Madonna delle Grazie 1, 80138 Naples, ItalyCognitive dysfunctions represent a core feature of schizophrenia-spectrum disorders due to their presence throughout different illness stages and their impact on functioning. Abnormalities in electrophysiology (EEG) measures are highly related to these impairments, but the use of EEG indices in clinical practice is still limited. A systematic review of articles using Pubmed, Scopus and PsychINFO was undertaken in November 2021 to provide an overview of the relationships between EEG indices and cognitive impairment in schizophrenia-spectrum disorders. Out of 2433 screened records, 135 studies were included in a qualitative review. Although the results were heterogeneous, some significant correlations were identified. In particular, abnormalities in alpha, theta and gamma activity, as well as in MMN and P300, were associated with impairments in cognitive domains such as attention, working memory, visual and verbal learning and executive functioning during at-risk mental states, early and chronic stages of schizophrenia-spectrum disorders. The review suggests that machine learning approaches together with a careful selection of validated EEG and cognitive indices and characterization of clinical phenotypes might contribute to increase the use of EEG-based measures in clinical settings.https://www.mdpi.com/2075-4418/12/9/2193electroencephalogram (EEG)cognitionschizophreniabiomarkers |
| spellingShingle | Andrea Perrottelli Giulia Maria Giordano Francesco Brando Luigi Giuliani Pasquale Pezzella Armida Mucci Silvana Galderisi Unveiling the Associations between EEG Indices and Cognitive Deficits in Schizophrenia-Spectrum Disorders: A Systematic Review Diagnostics electroencephalogram (EEG) cognition schizophrenia biomarkers |
| title | Unveiling the Associations between EEG Indices and Cognitive Deficits in Schizophrenia-Spectrum Disorders: A Systematic Review |
| title_full | Unveiling the Associations between EEG Indices and Cognitive Deficits in Schizophrenia-Spectrum Disorders: A Systematic Review |
| title_fullStr | Unveiling the Associations between EEG Indices and Cognitive Deficits in Schizophrenia-Spectrum Disorders: A Systematic Review |
| title_full_unstemmed | Unveiling the Associations between EEG Indices and Cognitive Deficits in Schizophrenia-Spectrum Disorders: A Systematic Review |
| title_short | Unveiling the Associations between EEG Indices and Cognitive Deficits in Schizophrenia-Spectrum Disorders: A Systematic Review |
| title_sort | unveiling the associations between eeg indices and cognitive deficits in schizophrenia spectrum disorders a systematic review |
| topic | electroencephalogram (EEG) cognition schizophrenia biomarkers |
| url | https://www.mdpi.com/2075-4418/12/9/2193 |
| work_keys_str_mv | AT andreaperrottelli unveilingtheassociationsbetweeneegindicesandcognitivedeficitsinschizophreniaspectrumdisordersasystematicreview AT giuliamariagiordano unveilingtheassociationsbetweeneegindicesandcognitivedeficitsinschizophreniaspectrumdisordersasystematicreview AT francescobrando unveilingtheassociationsbetweeneegindicesandcognitivedeficitsinschizophreniaspectrumdisordersasystematicreview AT luigigiuliani unveilingtheassociationsbetweeneegindicesandcognitivedeficitsinschizophreniaspectrumdisordersasystematicreview AT pasqualepezzella unveilingtheassociationsbetweeneegindicesandcognitivedeficitsinschizophreniaspectrumdisordersasystematicreview AT armidamucci unveilingtheassociationsbetweeneegindicesandcognitivedeficitsinschizophreniaspectrumdisordersasystematicreview AT silvanagalderisi unveilingtheassociationsbetweeneegindicesandcognitivedeficitsinschizophreniaspectrumdisordersasystematicreview |