Update on Optimal Management of Acute Myeloid Leukemia
Acute myeloid leukemia (AML) represents a malignant accumulation of immature myeloid cells in the marrow, presenting with impaired hematopoiesis and its attendant complications, including bleeding, infection, and organ infiltration. Chromosomal abnormalities remain the most powerful predictors of AM...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2013-01-01
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| Series: | Clinical Medicine Insights: Oncology |
| Online Access: | https://doi.org/10.4137/CMO.S8528 |
| _version_ | 1818306871027564544 |
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| author | Fuad El Rassi Martha Arellano |
| author_facet | Fuad El Rassi Martha Arellano |
| author_sort | Fuad El Rassi |
| collection | DOAJ |
| description | Acute myeloid leukemia (AML) represents a malignant accumulation of immature myeloid cells in the marrow, presenting with impaired hematopoiesis and its attendant complications, including bleeding, infection, and organ infiltration. Chromosomal abnormalities remain the most powerful predictors of AML prognosis and help to identify a subgroup with favorable prognosis. However, the majority of AML patients who are not in the favorable category succumb to the disease. Therefore, better efforts to identify those patients who may benefit from more aggressive and investigational therapeutic approaches are needed. Newer molecular markers aim at better characterizing the large group of intermediate-risk patients and to identify newer targets for therapy. A group that has seen little improvement over the years is the older AML group, usually defined as age ≥ 60. Efforts to develop less intensive but equally efficacious therapy for this vulnerable population are underway. |
| first_indexed | 2024-12-13T06:49:22Z |
| format | Article |
| id | doaj.art-a6a8d8bb9c974fd294006db74344d167 |
| institution | Directory Open Access Journal |
| issn | 1179-5549 |
| language | English |
| last_indexed | 2024-12-13T06:49:22Z |
| publishDate | 2013-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical Medicine Insights: Oncology |
| spelling | doaj.art-a6a8d8bb9c974fd294006db74344d1672022-12-21T23:56:11ZengSAGE PublishingClinical Medicine Insights: Oncology1179-55492013-01-01710.4137/CMO.S8528Update on Optimal Management of Acute Myeloid LeukemiaFuad El Rassi0Martha Arellano1Winship Cancer Institute of Emory University, Atlanta, Georgia, USA.Winship Cancer Institute of Emory University, Atlanta, Georgia, USA.Acute myeloid leukemia (AML) represents a malignant accumulation of immature myeloid cells in the marrow, presenting with impaired hematopoiesis and its attendant complications, including bleeding, infection, and organ infiltration. Chromosomal abnormalities remain the most powerful predictors of AML prognosis and help to identify a subgroup with favorable prognosis. However, the majority of AML patients who are not in the favorable category succumb to the disease. Therefore, better efforts to identify those patients who may benefit from more aggressive and investigational therapeutic approaches are needed. Newer molecular markers aim at better characterizing the large group of intermediate-risk patients and to identify newer targets for therapy. A group that has seen little improvement over the years is the older AML group, usually defined as age ≥ 60. Efforts to develop less intensive but equally efficacious therapy for this vulnerable population are underway.https://doi.org/10.4137/CMO.S8528 |
| spellingShingle | Fuad El Rassi Martha Arellano Update on Optimal Management of Acute Myeloid Leukemia Clinical Medicine Insights: Oncology |
| title | Update on Optimal Management of Acute Myeloid Leukemia |
| title_full | Update on Optimal Management of Acute Myeloid Leukemia |
| title_fullStr | Update on Optimal Management of Acute Myeloid Leukemia |
| title_full_unstemmed | Update on Optimal Management of Acute Myeloid Leukemia |
| title_short | Update on Optimal Management of Acute Myeloid Leukemia |
| title_sort | update on optimal management of acute myeloid leukemia |
| url | https://doi.org/10.4137/CMO.S8528 |
| work_keys_str_mv | AT fuadelrassi updateonoptimalmanagementofacutemyeloidleukemia AT marthaarellano updateonoptimalmanagementofacutemyeloidleukemia |