The onset of circulation triggers a metabolic switch required for endothelial to hematopoietic transition

The onset of circulation triggers a metabolic switch required for endothelial to hematopoietic transition

Summary: Hematopoietic stem cells (HSCs) emerge during development from the vascular wall of the main embryonic arteries. The onset of circulation triggers several processes that provide critical external factors for HSC generation. Nevertheless, it is not fully understood how and when the onset of...

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Main Authors: Emanuele Azzoni, Vincent Frontera, Giorgio Anselmi, Christina Rode, Chela James, Elitza M. Deltcheva, Atanasiu S. Demian, John Brown, Cristiana Barone, Arianna Patelli, Joe R. Harman, Matthew Nicholls, Simon J. Conway, Edward Morrissey, Sten Eirik W. Jacobsen, Duncan B. Sparrow, Adrian L. Harris, Tariq Enver, Marella F.T.R. de Bruijn
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721015977

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