Recapsoma<sup>®</sup>: A Novel Mixture Based on Bergamot, Ipomoea Batatas, Policosanol Extracts and Liposomal Berberine for the Treatment of Hypercholesterolemia
Cardiovascular disease (CVD) is considered one of the major causes of mortality worldwide. Epidemiological studies have shown that regular consumption of phenols is inversely associated with cardiovascular disease, and the use of nutraceuticals and functional foods can provide protective, preventive...
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| Format: | Article |
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MDPI AG
2022-07-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/12/8/1162 |
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| author | Chiara Amante Tiziana Esposito Gianni Luccheo Luigi Luccheo Paola Russo Pasquale Del Gaudio |
| author_facet | Chiara Amante Tiziana Esposito Gianni Luccheo Luigi Luccheo Paola Russo Pasquale Del Gaudio |
| author_sort | Chiara Amante |
| collection | DOAJ |
| description | Cardiovascular disease (CVD) is considered one of the major causes of mortality worldwide. Epidemiological studies have shown that regular consumption of phenols is inversely associated with cardiovascular disease, and the use of nutraceuticals and functional foods can provide protective, preventive, and possibly curative effects in CVD. A novel mixture of different natural substances named Recapsoma<sup>®</sup> (bergamot, liposomal berberine, Ipomoea batatas, oleuropein, polycosanols, and vitamin E) has been produced, and its anti-dyslipidaemic efficacy has been tested, specifically studying the in vitro effects on the mechanisms of action underlying cholesterol synthesis, triglycerides, and LDL-cholesterol oxidation. The work has demonstrated the ability of this herbal extract mixture to inhibit the action of PCSK, ACAT, PAP, and HMGR and to increase the LDL receptor (LDLR), underlying the synergistic effect of the mixture over the single components. Such results suggest that the Recapsoma<sup>®</sup> mixture could be used as a tool for controlling hypercholesterolemia, and an alternative to statins, especially for those patients with metabolic syndrome. |
| first_indexed | 2024-03-09T04:13:18Z |
| format | Article |
| id | doaj.art-a6a980be350440d38bd25f06e7de1da6 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-09T04:13:18Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-a6a980be350440d38bd25f06e7de1da62023-12-03T13:58:39ZengMDPI AGLife2075-17292022-07-01128116210.3390/life12081162Recapsoma<sup>®</sup>: A Novel Mixture Based on Bergamot, Ipomoea Batatas, Policosanol Extracts and Liposomal Berberine for the Treatment of HypercholesterolemiaChiara Amante0Tiziana Esposito1Gianni Luccheo2Luigi Luccheo3Paola Russo4Pasquale Del Gaudio5Department of Pharmacy, University of Salerno, via Giovanni Paolo II, 132, 84084 Fisciano, ItalyDepartment of Pharmacy, University of Salerno, via Giovanni Paolo II, 132, 84084 Fisciano, ItalyLaboratori Nutriphyt s.r.l., via Rosario Livatino, 84083 Castel San Giorgio, ItalyLaboratori Nutriphyt s.r.l., via Rosario Livatino, 84083 Castel San Giorgio, ItalyDepartment of Pharmacy, University of Salerno, via Giovanni Paolo II, 132, 84084 Fisciano, ItalyDepartment of Pharmacy, University of Salerno, via Giovanni Paolo II, 132, 84084 Fisciano, ItalyCardiovascular disease (CVD) is considered one of the major causes of mortality worldwide. Epidemiological studies have shown that regular consumption of phenols is inversely associated with cardiovascular disease, and the use of nutraceuticals and functional foods can provide protective, preventive, and possibly curative effects in CVD. A novel mixture of different natural substances named Recapsoma<sup>®</sup> (bergamot, liposomal berberine, Ipomoea batatas, oleuropein, polycosanols, and vitamin E) has been produced, and its anti-dyslipidaemic efficacy has been tested, specifically studying the in vitro effects on the mechanisms of action underlying cholesterol synthesis, triglycerides, and LDL-cholesterol oxidation. The work has demonstrated the ability of this herbal extract mixture to inhibit the action of PCSK, ACAT, PAP, and HMGR and to increase the LDL receptor (LDLR), underlying the synergistic effect of the mixture over the single components. Such results suggest that the Recapsoma<sup>®</sup> mixture could be used as a tool for controlling hypercholesterolemia, and an alternative to statins, especially for those patients with metabolic syndrome.https://www.mdpi.com/2075-1729/12/8/1162Recapsoma<sup>®</sup>bergamot extractliposomal berberineipomea batatas extractoleuropeinvitamin E |
| spellingShingle | Chiara Amante Tiziana Esposito Gianni Luccheo Luigi Luccheo Paola Russo Pasquale Del Gaudio Recapsoma<sup>®</sup>: A Novel Mixture Based on Bergamot, Ipomoea Batatas, Policosanol Extracts and Liposomal Berberine for the Treatment of Hypercholesterolemia Life Recapsoma<sup>®</sup> bergamot extract liposomal berberine ipomea batatas extract oleuropein vitamin E |
| title | Recapsoma<sup>®</sup>: A Novel Mixture Based on Bergamot, Ipomoea Batatas, Policosanol Extracts and Liposomal Berberine for the Treatment of Hypercholesterolemia |
| title_full | Recapsoma<sup>®</sup>: A Novel Mixture Based on Bergamot, Ipomoea Batatas, Policosanol Extracts and Liposomal Berberine for the Treatment of Hypercholesterolemia |
| title_fullStr | Recapsoma<sup>®</sup>: A Novel Mixture Based on Bergamot, Ipomoea Batatas, Policosanol Extracts and Liposomal Berberine for the Treatment of Hypercholesterolemia |
| title_full_unstemmed | Recapsoma<sup>®</sup>: A Novel Mixture Based on Bergamot, Ipomoea Batatas, Policosanol Extracts and Liposomal Berberine for the Treatment of Hypercholesterolemia |
| title_short | Recapsoma<sup>®</sup>: A Novel Mixture Based on Bergamot, Ipomoea Batatas, Policosanol Extracts and Liposomal Berberine for the Treatment of Hypercholesterolemia |
| title_sort | recapsoma sup r sup a novel mixture based on bergamot ipomoea batatas policosanol extracts and liposomal berberine for the treatment of hypercholesterolemia |
| topic | Recapsoma<sup>®</sup> bergamot extract liposomal berberine ipomea batatas extract oleuropein vitamin E |
| url | https://www.mdpi.com/2075-1729/12/8/1162 |
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