Plasmalogen Replacement Therapy
Plasmalogens, a subclass of glycerophospholipids containing a vinyl-ether bond, are one of the major components of biological membranes. Changes in plasmalogen content and molecular species have been reported in a variety of pathological conditions ranging from inherited to metabolic and degenerativ...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Membranes |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0375/11/11/838 |
| _version_ | 1797509459794198528 |
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| author | José Carlos Bozelli Richard M. Epand |
| author_facet | José Carlos Bozelli Richard M. Epand |
| author_sort | José Carlos Bozelli |
| collection | DOAJ |
| description | Plasmalogens, a subclass of glycerophospholipids containing a vinyl-ether bond, are one of the major components of biological membranes. Changes in plasmalogen content and molecular species have been reported in a variety of pathological conditions ranging from inherited to metabolic and degenerative diseases. Most of these diseases have no treatment, and attempts to develop a therapy have been focusing primarily on protein/nucleic acid molecular targets. However, recent studies have shifted attention to lipids as the basis of a therapeutic strategy. In these pathological conditions, the use of plasmalogen replacement therapy (PRT) has been shown to be a successful way to restore plasmalogen levels as well as to ameliorate the disease phenotype in different clinical settings. Here, the current state of PRT will be reviewed as well as a discussion of future perspectives in PRT. It is proposed that the use of PRT provides a modern and innovative molecular medicine approach aiming at improving health outcomes in different conditions with clinically unmet needs. |
| first_indexed | 2024-03-10T05:18:04Z |
| format | Article |
| id | doaj.art-a6aa1ea3512148efbd25a5207d060c45 |
| institution | Directory Open Access Journal |
| issn | 2077-0375 |
| language | English |
| last_indexed | 2024-03-10T05:18:04Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Membranes |
| spelling | doaj.art-a6aa1ea3512148efbd25a5207d060c452023-11-23T00:19:21ZengMDPI AGMembranes2077-03752021-10-01111183810.3390/membranes11110838Plasmalogen Replacement TherapyJosé Carlos Bozelli0Richard M. Epand1Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4L8, CanadaDepartment of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4L8, CanadaPlasmalogens, a subclass of glycerophospholipids containing a vinyl-ether bond, are one of the major components of biological membranes. Changes in plasmalogen content and molecular species have been reported in a variety of pathological conditions ranging from inherited to metabolic and degenerative diseases. Most of these diseases have no treatment, and attempts to develop a therapy have been focusing primarily on protein/nucleic acid molecular targets. However, recent studies have shifted attention to lipids as the basis of a therapeutic strategy. In these pathological conditions, the use of plasmalogen replacement therapy (PRT) has been shown to be a successful way to restore plasmalogen levels as well as to ameliorate the disease phenotype in different clinical settings. Here, the current state of PRT will be reviewed as well as a discussion of future perspectives in PRT. It is proposed that the use of PRT provides a modern and innovative molecular medicine approach aiming at improving health outcomes in different conditions with clinically unmet needs.https://www.mdpi.com/2077-0375/11/11/838plasmalogenplasmalogen-related diseasesdegenerative and metabolic disordersmembrane lipid therapyplasmalogen replacement therapy |
| spellingShingle | José Carlos Bozelli Richard M. Epand Plasmalogen Replacement Therapy Membranes plasmalogen plasmalogen-related diseases degenerative and metabolic disorders membrane lipid therapy plasmalogen replacement therapy |
| title | Plasmalogen Replacement Therapy |
| title_full | Plasmalogen Replacement Therapy |
| title_fullStr | Plasmalogen Replacement Therapy |
| title_full_unstemmed | Plasmalogen Replacement Therapy |
| title_short | Plasmalogen Replacement Therapy |
| title_sort | plasmalogen replacement therapy |
| topic | plasmalogen plasmalogen-related diseases degenerative and metabolic disorders membrane lipid therapy plasmalogen replacement therapy |
| url | https://www.mdpi.com/2077-0375/11/11/838 |
| work_keys_str_mv | AT josecarlosbozelli plasmalogenreplacementtherapy AT richardmepand plasmalogenreplacementtherapy |