Presence of SARS-CoV-2 in middle ear fluid and characterization of otitis media with effusion in patients with COVID-19
Objectives: This study sought to determine whether SARS-CoV-2 is present in the middle ear fluid (MEF) of patients with COVID-19 who have otitis media with effusion (OME). Methods: A case-control study was designed to detect SARS-CoV-2 and six other common respiratory viruses (influenza A virus, inf...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | International Journal of Infectious Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971223007099 |
| _version_ | 1797676637353934848 |
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| author | Yue Fan Ruzhen Gao Yingying Shang Xu Tian Yang Zhao Xingming Chen |
| author_facet | Yue Fan Ruzhen Gao Yingying Shang Xu Tian Yang Zhao Xingming Chen |
| author_sort | Yue Fan |
| collection | DOAJ |
| description | Objectives: This study sought to determine whether SARS-CoV-2 is present in the middle ear fluid (MEF) of patients with COVID-19 who have otitis media with effusion (OME). Methods: A case-control study was designed to detect SARS-CoV-2 and six other common respiratory viruses (influenza A virus, influenza B virus, respiratory syncytial virus, adenovirus, human rhinovirus [HRV], and mycoplasma pneumonia) by polymerase chain reaction (PCR) in the MEF of patients with OME. Follow-up tests, including pure-tone audiometry and tympanometry, were conducted. Results: In the COVID-19 group, 18 of 27 MEF specimens were PCR-positive for SARS-CoV-2, with cycle thresholds ranging from 24.9-42.2. And one patient tested positive for the HRV. In the control group, all 15 MEF specimens were PCR-negative for SARS-CoV-2, but two patients tested positive for the HRV. After treatment for OME, 11 patients (40.7%) reported complete resolution, 14 (51.9%) reported improvement, and two (7.4%) reported no change. The average improvement in hearing was 14.5 ± 8.1 dB, and the average air-bone gap decrease was 13.5 ± 9.0 dB. Conclusion: This study confirmed the presence of SARS-CoV-2 in the MEF of patients who were previously COVID-19-positive suggesting a possible association between COVID-19 and OME. OME should be considered a possible symptom of COVID-19. |
| first_indexed | 2024-03-11T22:32:08Z |
| format | Article |
| id | doaj.art-a6ab9ce9ed5747dcaf9142a6e38db7c6 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-03-11T22:32:08Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-a6ab9ce9ed5747dcaf9142a6e38db7c62023-09-23T05:10:46ZengElsevierInternational Journal of Infectious Diseases1201-97122023-11-011364448Presence of SARS-CoV-2 in middle ear fluid and characterization of otitis media with effusion in patients with COVID-19Yue Fan0Ruzhen Gao1Yingying Shang2Xu Tian3Yang Zhao4Xingming Chen5Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, ChinaDepartment of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China; Corresponding author: Tel: 8613901077778.Objectives: This study sought to determine whether SARS-CoV-2 is present in the middle ear fluid (MEF) of patients with COVID-19 who have otitis media with effusion (OME). Methods: A case-control study was designed to detect SARS-CoV-2 and six other common respiratory viruses (influenza A virus, influenza B virus, respiratory syncytial virus, adenovirus, human rhinovirus [HRV], and mycoplasma pneumonia) by polymerase chain reaction (PCR) in the MEF of patients with OME. Follow-up tests, including pure-tone audiometry and tympanometry, were conducted. Results: In the COVID-19 group, 18 of 27 MEF specimens were PCR-positive for SARS-CoV-2, with cycle thresholds ranging from 24.9-42.2. And one patient tested positive for the HRV. In the control group, all 15 MEF specimens were PCR-negative for SARS-CoV-2, but two patients tested positive for the HRV. After treatment for OME, 11 patients (40.7%) reported complete resolution, 14 (51.9%) reported improvement, and two (7.4%) reported no change. The average improvement in hearing was 14.5 ± 8.1 dB, and the average air-bone gap decrease was 13.5 ± 9.0 dB. Conclusion: This study confirmed the presence of SARS-CoV-2 in the MEF of patients who were previously COVID-19-positive suggesting a possible association between COVID-19 and OME. OME should be considered a possible symptom of COVID-19.http://www.sciencedirect.com/science/article/pii/S1201971223007099Otitis media with effusionMiddle ear fluidSARS-CoV-2COVID-19Respiratory viruses |
| spellingShingle | Yue Fan Ruzhen Gao Yingying Shang Xu Tian Yang Zhao Xingming Chen Presence of SARS-CoV-2 in middle ear fluid and characterization of otitis media with effusion in patients with COVID-19 International Journal of Infectious Diseases Otitis media with effusion Middle ear fluid SARS-CoV-2 COVID-19 Respiratory viruses |
| title | Presence of SARS-CoV-2 in middle ear fluid and characterization of otitis media with effusion in patients with COVID-19 |
| title_full | Presence of SARS-CoV-2 in middle ear fluid and characterization of otitis media with effusion in patients with COVID-19 |
| title_fullStr | Presence of SARS-CoV-2 in middle ear fluid and characterization of otitis media with effusion in patients with COVID-19 |
| title_full_unstemmed | Presence of SARS-CoV-2 in middle ear fluid and characterization of otitis media with effusion in patients with COVID-19 |
| title_short | Presence of SARS-CoV-2 in middle ear fluid and characterization of otitis media with effusion in patients with COVID-19 |
| title_sort | presence of sars cov 2 in middle ear fluid and characterization of otitis media with effusion in patients with covid 19 |
| topic | Otitis media with effusion Middle ear fluid SARS-CoV-2 COVID-19 Respiratory viruses |
| url | http://www.sciencedirect.com/science/article/pii/S1201971223007099 |
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