Correction of cyclophosphan toxicity by polyphenolic hepatoprotectors
Efficiency of lokhein, maksar and karsil hepatoprotectors in the treatment of cyclophosphan damaged liver has been investigated. Hepatoprotectors decrease the overall cytostatic toxicity, reduce the hepatocyte necrosis and the cell infiltration of liver parenchyma, cause the hyperaminotransferase an...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2004-03-01
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| Series: | Бюллетень сибирской медицины |
| Subjects: | |
| Online Access: | https://bulletin.ssmu.ru/jour/article/view/3599 |
| _version_ | 1827992019157385216 |
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| author | A. S. Saratikov A. V. Ratjkin V. N. Frolov V. S. Chuchalin |
| author_facet | A. S. Saratikov A. V. Ratjkin V. N. Frolov V. S. Chuchalin |
| author_sort | A. S. Saratikov |
| collection | DOAJ |
| description | Efficiency of lokhein, maksar and karsil hepatoprotectors in the treatment of cyclophosphan damaged liver has been investigated. Hepatoprotectors decrease the overall cytostatic toxicity, reduce the hepatocyte necrosis and the cell infiltration of liver parenchyma, cause the hyperaminotransferase and hyperbilirubin regression, stimulate the bilirubin conjugation and normalize the protein content in blood. Lokhein prevents most efficiently the development of morphologic disturbances in liver and recovers most of biochemical abnormalities at cyclophosphan intoxication. |
| first_indexed | 2024-04-10T01:14:19Z |
| format | Article |
| id | doaj.art-a6abbbd8fe294aea8f949d7b569c210f |
| institution | Directory Open Access Journal |
| issn | 1682-0363 1819-3684 |
| language | English |
| last_indexed | 2024-04-10T01:14:19Z |
| publishDate | 2004-03-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj.art-a6abbbd8fe294aea8f949d7b569c210f2023-03-13T09:58:02ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842004-03-0131525610.20538/1682-0363-2004-1-52-562243Correction of cyclophosphan toxicity by polyphenolic hepatoprotectorsA. S. Saratikov0A. V. Ratjkin1V. N. Frolov2V. S. Chuchalin3Сибирский государственный медицинский университетСибирский государственный медицинский университетСибирский государственный медицинский университетСибирский государственный медицинский университетEfficiency of lokhein, maksar and karsil hepatoprotectors in the treatment of cyclophosphan damaged liver has been investigated. Hepatoprotectors decrease the overall cytostatic toxicity, reduce the hepatocyte necrosis and the cell infiltration of liver parenchyma, cause the hyperaminotransferase and hyperbilirubin regression, stimulate the bilirubin conjugation and normalize the protein content in blood. Lokhein prevents most efficiently the development of morphologic disturbances in liver and recovers most of biochemical abnormalities at cyclophosphan intoxication.https://bulletin.ssmu.ru/jour/article/view/3599гепатопротекторылохеинмаксаркарсилциклофосфан |
| spellingShingle | A. S. Saratikov A. V. Ratjkin V. N. Frolov V. S. Chuchalin Correction of cyclophosphan toxicity by polyphenolic hepatoprotectors Бюллетень сибирской медицины гепатопротекторы лохеин максар карсил циклофосфан |
| title | Correction of cyclophosphan toxicity by polyphenolic hepatoprotectors |
| title_full | Correction of cyclophosphan toxicity by polyphenolic hepatoprotectors |
| title_fullStr | Correction of cyclophosphan toxicity by polyphenolic hepatoprotectors |
| title_full_unstemmed | Correction of cyclophosphan toxicity by polyphenolic hepatoprotectors |
| title_short | Correction of cyclophosphan toxicity by polyphenolic hepatoprotectors |
| title_sort | correction of cyclophosphan toxicity by polyphenolic hepatoprotectors |
| topic | гепатопротекторы лохеин максар карсил циклофосфан |
| url | https://bulletin.ssmu.ru/jour/article/view/3599 |
| work_keys_str_mv | AT assaratikov correctionofcyclophosphantoxicitybypolyphenolichepatoprotectors AT avratjkin correctionofcyclophosphantoxicitybypolyphenolichepatoprotectors AT vnfrolov correctionofcyclophosphantoxicitybypolyphenolichepatoprotectors AT vschuchalin correctionofcyclophosphantoxicitybypolyphenolichepatoprotectors |