Impact of ATP-citrate lyase catalytic activity and serine 455 phosphorylation on histone acetylation and inflammatory responses in human monocytic THP-1 cells

Impact of ATP-citrate lyase catalytic activity and serine 455 phosphorylation on histone acetylation and inflammatory responses in human monocytic THP-1 cells

ATP-citrate lyase (ACLY) is a key enzyme provoking metabolic and epigenetic gene regulation. Molecularly, these functions are exerted by the provision of acetyl-coenzyme A, which is then used as a substrate for de novo lipogenesis or as an acetyl-group donor in acetylation reactions. It has been dem...

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Bibliographic Details
Main Authors: Monica Dominguez, Verena Truemper, Ana Carolina Mota, Bernhard Brüne, Dmitry Namgaladze
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Immunology
Subjects:
ATP-citrate lyase
histone acetylation
macrophages
metabolism
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.906127/full

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