Case Report: Capillary Leak Syndrome With Kidney Transplant Failure Following Autologous Mesenchymal Stem Cell Therapy
Mesenchymal stem cells (MSCs) have attracted great interest in the field of kidney transplantation due to their immunomodulatory and reparative properties. In registered clinical trials, MSCs have been used before, at the time of, or early after transplantation and have been reported to be well-tole...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-07-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2021.708744/full |
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| author | Željka Večerić-Haler Željka Večerić-Haler Nika Kojc Matjaž Sever Matjaž Sever Samo Zver Samo Zver Urban Švajger Primož Poženel Katrina Hartman Tereza Urdih Gregor Mlinšek Gregor Mlinšek Manca Oblak Andreja Aleš Rigler Alojz Ihan Jadranka Buturović Ponikvar Jadranka Buturović Ponikvar Philip P. Halloran Miha Arnol Miha Arnol |
| author_facet | Željka Večerić-Haler Željka Večerić-Haler Nika Kojc Matjaž Sever Matjaž Sever Samo Zver Samo Zver Urban Švajger Primož Poženel Katrina Hartman Tereza Urdih Gregor Mlinšek Gregor Mlinšek Manca Oblak Andreja Aleš Rigler Alojz Ihan Jadranka Buturović Ponikvar Jadranka Buturović Ponikvar Philip P. Halloran Miha Arnol Miha Arnol |
| author_sort | Željka Večerić-Haler |
| collection | DOAJ |
| description | Mesenchymal stem cells (MSCs) have attracted great interest in the field of kidney transplantation due to their immunomodulatory and reparative properties. In registered clinical trials, MSCs have been used before, at the time of, or early after transplantation and have been reported to be well-tolerated with no serious safety concerns. No results are available on the use of MSCs in the late post-transplant period. Here, we present a case report of a severe systemic complication mimicking capillary leak syndrome with ultimate kidney transplant failure after autologous transplantation of MSCs used as rescue treatment of late antibody-mediated kidney allograft rejection. |
| first_indexed | 2024-12-22T12:57:45Z |
| format | Article |
| id | doaj.art-a6adb45b32564318ba1507aca3e608c6 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-22T12:57:45Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-a6adb45b32564318ba1507aca3e608c62022-12-21T18:25:05ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2021-07-01810.3389/fmed.2021.708744708744Case Report: Capillary Leak Syndrome With Kidney Transplant Failure Following Autologous Mesenchymal Stem Cell TherapyŽeljka Večerić-Haler0Željka Večerić-Haler1Nika Kojc2Matjaž Sever3Matjaž Sever4Samo Zver5Samo Zver6Urban Švajger7Primož Poženel8Katrina Hartman9Tereza Urdih10Gregor Mlinšek11Gregor Mlinšek12Manca Oblak13Andreja Aleš Rigler14Alojz Ihan15Jadranka Buturović Ponikvar16Jadranka Buturović Ponikvar17Philip P. Halloran18Miha Arnol19Miha Arnol20Department of Nephrology, University Medical Centre Ljubljana, Ljubljana, SloveniaFaculty of Medicine, University of Ljubljana, Ljubljana, SloveniaInstitute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, SloveniaFaculty of Medicine, University of Ljubljana, Ljubljana, SloveniaDepartment of Haematology, University Medical Centre Ljubljana, Ljubljana, SloveniaFaculty of Medicine, University of Ljubljana, Ljubljana, SloveniaDepartment of Haematology, University Medical Centre Ljubljana, Ljubljana, SloveniaDivision for Cells and Tissue, Blood Transfusion Centre of Slovenia, Ljubljana, SloveniaDivision for Cells and Tissue, Blood Transfusion Centre of Slovenia, Ljubljana, SloveniaDivision for Cells and Tissue, Blood Transfusion Centre of Slovenia, Ljubljana, SloveniaDepartment of Haematology, University Medical Centre Ljubljana, Ljubljana, SloveniaDepartment of Nephrology, University Medical Centre Ljubljana, Ljubljana, SloveniaFaculty of Medicine, University of Ljubljana, Ljubljana, SloveniaDepartment of Nephrology, University Medical Centre Ljubljana, Ljubljana, SloveniaDepartment of Nephrology, University Medical Centre Ljubljana, Ljubljana, SloveniaInstitute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana, SloveniaDepartment of Nephrology, University Medical Centre Ljubljana, Ljubljana, SloveniaFaculty of Medicine, University of Ljubljana, Ljubljana, SloveniaDivision of Nephrology and Transplant Immunology, University of Alberta, Alberta Transplant Applied Genomics Centre, Edmonton, AB, CanadaDepartment of Nephrology, University Medical Centre Ljubljana, Ljubljana, SloveniaFaculty of Medicine, University of Ljubljana, Ljubljana, SloveniaMesenchymal stem cells (MSCs) have attracted great interest in the field of kidney transplantation due to their immunomodulatory and reparative properties. In registered clinical trials, MSCs have been used before, at the time of, or early after transplantation and have been reported to be well-tolerated with no serious safety concerns. No results are available on the use of MSCs in the late post-transplant period. Here, we present a case report of a severe systemic complication mimicking capillary leak syndrome with ultimate kidney transplant failure after autologous transplantation of MSCs used as rescue treatment of late antibody-mediated kidney allograft rejection.https://www.frontiersin.org/articles/10.3389/fmed.2021.708744/fullmesenchymal stem cellkidney graftkidney transplantkidney graft failureautologous stem cellstem cell transplant |
| spellingShingle | Željka Večerić-Haler Željka Večerić-Haler Nika Kojc Matjaž Sever Matjaž Sever Samo Zver Samo Zver Urban Švajger Primož Poženel Katrina Hartman Tereza Urdih Gregor Mlinšek Gregor Mlinšek Manca Oblak Andreja Aleš Rigler Alojz Ihan Jadranka Buturović Ponikvar Jadranka Buturović Ponikvar Philip P. Halloran Miha Arnol Miha Arnol Case Report: Capillary Leak Syndrome With Kidney Transplant Failure Following Autologous Mesenchymal Stem Cell Therapy Frontiers in Medicine mesenchymal stem cell kidney graft kidney transplant kidney graft failure autologous stem cell stem cell transplant |
| title | Case Report: Capillary Leak Syndrome With Kidney Transplant Failure Following Autologous Mesenchymal Stem Cell Therapy |
| title_full | Case Report: Capillary Leak Syndrome With Kidney Transplant Failure Following Autologous Mesenchymal Stem Cell Therapy |
| title_fullStr | Case Report: Capillary Leak Syndrome With Kidney Transplant Failure Following Autologous Mesenchymal Stem Cell Therapy |
| title_full_unstemmed | Case Report: Capillary Leak Syndrome With Kidney Transplant Failure Following Autologous Mesenchymal Stem Cell Therapy |
| title_short | Case Report: Capillary Leak Syndrome With Kidney Transplant Failure Following Autologous Mesenchymal Stem Cell Therapy |
| title_sort | case report capillary leak syndrome with kidney transplant failure following autologous mesenchymal stem cell therapy |
| topic | mesenchymal stem cell kidney graft kidney transplant kidney graft failure autologous stem cell stem cell transplant |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2021.708744/full |
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