Decision‐making impairments under ambiguous and risky situations in patients with prefrontal tumor: A neuropsychological study
Abstract Introduction The neural mechanism underlying decision‐making, which is an important component of executive function, is complex and not fully understood. Few studies have directly investigated the two types of decision‐making functions – under ambiguity and under risk – in patients with bra...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Brain and Behavior |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/brb3.1951 |
| _version_ | 1818558887517749248 |
|---|---|
| author | Yuyang Wang Xukou Wang Kai Wang Bing Zhao Xingui Chen |
| author_facet | Yuyang Wang Xukou Wang Kai Wang Bing Zhao Xingui Chen |
| author_sort | Yuyang Wang |
| collection | DOAJ |
| description | Abstract Introduction The neural mechanism underlying decision‐making, which is an important component of executive function, is complex and not fully understood. Few studies have directly investigated the two types of decision‐making functions – under ambiguity and under risk – in patients with brain tumors in different brain regions. Methods Participants were classified into the ventral prefrontal cortex tumor group (VPFC, n = 27), the dorsolateral prefrontal cortex tumor group (DLPFC, n = 29), and matched healthy controls (HCs, n = 32). All participants were given a battery of neuropsychological tests, and they then performed the Iowa Gambling Task (IGT) and the Game of Dice Task (GDT) to assess their decision‐making under ambiguity and under risk, respectively. Results The two patient groups performed significantly worse on attention, memory, information processing, and executive function. Additionally, patients in the DLPFC group performed significantly worse on the memory and information processing tests compared with the VPFC and HC groups. Conclusion This study found that the decision‐making functions of participants in the VPFC and DLPFC tumor groups were impaired to varying degrees. Among them, there was decision‐making impairment under ambiguity and under risk in the VPFC group, and there was decision‐making impairment under risk in the DLPFC group. |
| first_indexed | 2024-12-14T00:18:10Z |
| format | Article |
| id | doaj.art-a6ae2a47b9914b07a3e8f728a13ce418 |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-12-14T00:18:10Z |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-a6ae2a47b9914b07a3e8f728a13ce4182022-12-21T23:25:23ZengWileyBrain and Behavior2162-32792021-01-01111n/an/a10.1002/brb3.1951Decision‐making impairments under ambiguous and risky situations in patients with prefrontal tumor: A neuropsychological studyYuyang Wang0Xukou Wang1Kai Wang2Bing Zhao3Xingui Chen4Department of Neurosurgery the Second Affiliated Hospital of Anhui Medical University Hefei ChinaDepartment of Neurosurgery the Fourth Affiliated Hospital of Anhui Medical University Hefei ChinaCollaborative Innovation Centre of Neuropsychiatric Disorder and Mental Health Anhui Province ChinaDepartment of Neurosurgery the Second Affiliated Hospital of Anhui Medical University Hefei ChinaCollaborative Innovation Centre of Neuropsychiatric Disorder and Mental Health Anhui Province ChinaAbstract Introduction The neural mechanism underlying decision‐making, which is an important component of executive function, is complex and not fully understood. Few studies have directly investigated the two types of decision‐making functions – under ambiguity and under risk – in patients with brain tumors in different brain regions. Methods Participants were classified into the ventral prefrontal cortex tumor group (VPFC, n = 27), the dorsolateral prefrontal cortex tumor group (DLPFC, n = 29), and matched healthy controls (HCs, n = 32). All participants were given a battery of neuropsychological tests, and they then performed the Iowa Gambling Task (IGT) and the Game of Dice Task (GDT) to assess their decision‐making under ambiguity and under risk, respectively. Results The two patient groups performed significantly worse on attention, memory, information processing, and executive function. Additionally, patients in the DLPFC group performed significantly worse on the memory and information processing tests compared with the VPFC and HC groups. Conclusion This study found that the decision‐making functions of participants in the VPFC and DLPFC tumor groups were impaired to varying degrees. Among them, there was decision‐making impairment under ambiguity and under risk in the VPFC group, and there was decision‐making impairment under risk in the DLPFC group.https://doi.org/10.1002/brb3.1951brain tumorgame of dice taskiowa gambling taskprefrontal lobe |
| spellingShingle | Yuyang Wang Xukou Wang Kai Wang Bing Zhao Xingui Chen Decision‐making impairments under ambiguous and risky situations in patients with prefrontal tumor: A neuropsychological study Brain and Behavior brain tumor game of dice task iowa gambling task prefrontal lobe |
| title | Decision‐making impairments under ambiguous and risky situations in patients with prefrontal tumor: A neuropsychological study |
| title_full | Decision‐making impairments under ambiguous and risky situations in patients with prefrontal tumor: A neuropsychological study |
| title_fullStr | Decision‐making impairments under ambiguous and risky situations in patients with prefrontal tumor: A neuropsychological study |
| title_full_unstemmed | Decision‐making impairments under ambiguous and risky situations in patients with prefrontal tumor: A neuropsychological study |
| title_short | Decision‐making impairments under ambiguous and risky situations in patients with prefrontal tumor: A neuropsychological study |
| title_sort | decision making impairments under ambiguous and risky situations in patients with prefrontal tumor a neuropsychological study |
| topic | brain tumor game of dice task iowa gambling task prefrontal lobe |
| url | https://doi.org/10.1002/brb3.1951 |
| work_keys_str_mv | AT yuyangwang decisionmakingimpairmentsunderambiguousandriskysituationsinpatientswithprefrontaltumoraneuropsychologicalstudy AT xukouwang decisionmakingimpairmentsunderambiguousandriskysituationsinpatientswithprefrontaltumoraneuropsychologicalstudy AT kaiwang decisionmakingimpairmentsunderambiguousandriskysituationsinpatientswithprefrontaltumoraneuropsychologicalstudy AT bingzhao decisionmakingimpairmentsunderambiguousandriskysituationsinpatientswithprefrontaltumoraneuropsychologicalstudy AT xinguichen decisionmakingimpairmentsunderambiguousandriskysituationsinpatientswithprefrontaltumoraneuropsychologicalstudy |