Can fatigue predict walking capacity of patients with Parkinson’s disease?
ABSTRACT Although fatigue is an expressive symptom of Parkinson’s disease (PD), few studies have investigated the association between fatigue, mobility and walking capacity of these patients. Objective: To investigate whether fatigue is an independent factor associated with mobility and the walking...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Academia Brasileira de Neurologia (ABNEURO)
2020-03-01
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| Series: | Arquivos de Neuro-Psiquiatria |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2020000200070&tlng=en |
| _version_ | 1798020324499914752 |
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| author | Davi Vilela CARVALHO Renata Maria Silva SANTOS Helen Cardoso de MAGALHÃES Mariana Soares de SOUZA Paulo Pereira CHRISTO Camila Megale de ALMEIDA-LEITE Paula Luciana SCALZO |
| author_facet | Davi Vilela CARVALHO Renata Maria Silva SANTOS Helen Cardoso de MAGALHÃES Mariana Soares de SOUZA Paulo Pereira CHRISTO Camila Megale de ALMEIDA-LEITE Paula Luciana SCALZO |
| author_sort | Davi Vilela CARVALHO |
| collection | DOAJ |
| description | ABSTRACT Although fatigue is an expressive symptom of Parkinson’s disease (PD), few studies have investigated the association between fatigue, mobility and walking capacity of these patients. Objective: To investigate whether fatigue is an independent factor associated with mobility and the walking capacity in patients with PD. Methods: Forty-eight patients with PD (22 with fatigue) were tested for mobility and their walking capacity: Timed Up and Go (TUG), 10-Meter Walk Test (10MWT) at usual and fastest speed, and 6-Minute Walk Test (6MWT). Fatigue was measured with Parkinson’s Fatigue Scale (PFS-16). Linear regression analysis was used to investigate if fatigue is an independent factor contributing to variance in mobility and walking capacity. Results: There was a positive correlation between PFS-16 and TUG (rs=0.385; p=0.007). There was a negative correlation between PFS-16 and 10MWT at comfortable (r=-0.385; p=0.007) and fast speeds (r=-0.396; p=0.005), and 6MWT (r=-0.472; p=0.001). Linear regression analysis revealed that fatigue did not explain the variance of TUG and 10MWT. PFS-16, age and section III of UPDRS explained 49.6% (adjusted R2; p<0.001) variance in the 6MWT, and fatigue was the most significant predictor (F=-32.1; p=0.022). Conclusions: Fatigue is an independent factor contributing to the distance covered during 6MWT in patients with PD. Our results highlight the importance of recognition and management of this symptom. |
| first_indexed | 2024-04-11T16:55:46Z |
| format | Article |
| id | doaj.art-a6aeaf280a5c40cc884b9c07f5e2b8a7 |
| institution | Directory Open Access Journal |
| issn | 1678-4227 |
| language | English |
| last_indexed | 2024-04-11T16:55:46Z |
| publishDate | 2020-03-01 |
| publisher | Academia Brasileira de Neurologia (ABNEURO) |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj.art-a6aeaf280a5c40cc884b9c07f5e2b8a72022-12-22T04:13:17ZengAcademia Brasileira de Neurologia (ABNEURO)Arquivos de Neuro-Psiquiatria1678-42272020-03-01782707510.1590/0004-282x20190136Can fatigue predict walking capacity of patients with Parkinson’s disease?Davi Vilela CARVALHOhttps://orcid.org/0000-0002-7994-8325Renata Maria Silva SANTOShttps://orcid.org/0000-0001-5737-7712Helen Cardoso de MAGALHÃEShttps://orcid.org/0000-0003-0582-305XMariana Soares de SOUZAhttps://orcid.org/0000-0002-5301-003XPaulo Pereira CHRISTOhttps://orcid.org/0000-0003-1224-5243Camila Megale de ALMEIDA-LEITEhttps://orcid.org/0000-0003-2694-8521Paula Luciana SCALZOhttps://orcid.org/0000-0003-1383-8550ABSTRACT Although fatigue is an expressive symptom of Parkinson’s disease (PD), few studies have investigated the association between fatigue, mobility and walking capacity of these patients. Objective: To investigate whether fatigue is an independent factor associated with mobility and the walking capacity in patients with PD. Methods: Forty-eight patients with PD (22 with fatigue) were tested for mobility and their walking capacity: Timed Up and Go (TUG), 10-Meter Walk Test (10MWT) at usual and fastest speed, and 6-Minute Walk Test (6MWT). Fatigue was measured with Parkinson’s Fatigue Scale (PFS-16). Linear regression analysis was used to investigate if fatigue is an independent factor contributing to variance in mobility and walking capacity. Results: There was a positive correlation between PFS-16 and TUG (rs=0.385; p=0.007). There was a negative correlation between PFS-16 and 10MWT at comfortable (r=-0.385; p=0.007) and fast speeds (r=-0.396; p=0.005), and 6MWT (r=-0.472; p=0.001). Linear regression analysis revealed that fatigue did not explain the variance of TUG and 10MWT. PFS-16, age and section III of UPDRS explained 49.6% (adjusted R2; p<0.001) variance in the 6MWT, and fatigue was the most significant predictor (F=-32.1; p=0.022). Conclusions: Fatigue is an independent factor contributing to the distance covered during 6MWT in patients with PD. Our results highlight the importance of recognition and management of this symptom.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2020000200070&tlng=enParkinson’s diseasefatiguemobilitygait speedwalking capacity |
| spellingShingle | Davi Vilela CARVALHO Renata Maria Silva SANTOS Helen Cardoso de MAGALHÃES Mariana Soares de SOUZA Paulo Pereira CHRISTO Camila Megale de ALMEIDA-LEITE Paula Luciana SCALZO Can fatigue predict walking capacity of patients with Parkinson’s disease? Arquivos de Neuro-Psiquiatria Parkinson’s disease fatigue mobility gait speed walking capacity |
| title | Can fatigue predict walking capacity of patients with Parkinson’s disease? |
| title_full | Can fatigue predict walking capacity of patients with Parkinson’s disease? |
| title_fullStr | Can fatigue predict walking capacity of patients with Parkinson’s disease? |
| title_full_unstemmed | Can fatigue predict walking capacity of patients with Parkinson’s disease? |
| title_short | Can fatigue predict walking capacity of patients with Parkinson’s disease? |
| title_sort | can fatigue predict walking capacity of patients with parkinson s disease |
| topic | Parkinson’s disease fatigue mobility gait speed walking capacity |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2020000200070&tlng=en |
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