Effect of alpha-adrenoceptor antagonists on sexual function. A systematic review and meta-analysis
Background: Alpha-adrenoreceptor antagonists or alpha-blockers are used in the treatment of hypertension, in the therapy of benign prostatic hyperplasia and in medical expulsive treatment of ureteral stones. These agents may affect the sexual function, with differences between drugs within the same...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2022-06-01
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| Series: | Archivio Italiano di Urologia e Andrologia |
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| Online Access: | https://www.pagepressjournals.org/index.php/aiua/article/view/10711 |
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| author | Rawa Bapir Kamran Hassan Bhatti Ahmed Eliwa Herney Andrés García-Perdomo Nazim Gherabi Derek Hennessey Vittorio Magri Panagiotis Mourmouris Adama Ouattara Gianpaolo Perletti Joseph Philipraj Alberto Trinchieri Noor Buchholz |
| author_facet | Rawa Bapir Kamran Hassan Bhatti Ahmed Eliwa Herney Andrés García-Perdomo Nazim Gherabi Derek Hennessey Vittorio Magri Panagiotis Mourmouris Adama Ouattara Gianpaolo Perletti Joseph Philipraj Alberto Trinchieri Noor Buchholz |
| author_sort | Rawa Bapir |
| collection | DOAJ |
| description |
Background: Alpha-adrenoreceptor antagonists or alpha-blockers are used in the treatment of hypertension, in the therapy of benign prostatic hyperplasia and in medical expulsive treatment of ureteral stones. These agents may affect the sexual function, with differences between drugs within the same class, depending on their selectivity for receptor subtypes. The aim of this review was to analyze the effects of alpha-blockers on sexual function. Materials and methods: We conducted a systematic review and meta-analysis by searching PubMed, EMBASE and other databases for randomized controlled trials (RCTs) reporting sexual adverse effects in patients treated with alpha-blockers. Odds ratios for sexual dysfunction were calculated using random effects Mantel-Haenszel statistics. Results: Out of 608 records retrieved, 75 eligible RCTs were included in the meta-analysis. Compared with placebo, alphablockers were associated with increased odds of ejaculatory disorders both in patients with lower urinary tract symptoms (LUTS) associated to benign prostatic hyperplasia (BPH) (OR: 7.53, 95% CI: 3.77-15.02, Z = 5.73, p < 0.00001, I2 = 55%) and in patients with ureteral stones (OR: 2.88, 95% CI: 1.50-5.44, Z = 3.19, p < 0.001, I2 = 31%). Uroselective alpha-blockers showed higher odds of ejaculatory disorders. Conversely, nonselective alpha-blockers were not associated with higher odds of ejaculatory dysfunction. Silodosin was associated with increased odds of ejaculatory dysfunction compared with tamsulosin (OR: 3.52, 95% CI: 2.18-5.68, 15 series, 1512 participants, Z = 5.15, p < 0.00001, I2 = 0%). Naftopidil and alfuzosin showed lower odds of ejaculatory dysfunction compared to uroselective alpha-blockers.No statistically significant differences in the odds of erectile dysfunction were observed when alpha-blockers were compared to placebo.
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| first_indexed | 2024-04-12T09:46:49Z |
| format | Article |
| id | doaj.art-a6af3f202b2240378a96f91ed6ebb16f |
| institution | Directory Open Access Journal |
| issn | 1124-3562 2282-4197 |
| language | English |
| last_indexed | 2024-04-12T09:46:49Z |
| publishDate | 2022-06-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Archivio Italiano di Urologia e Andrologia |
| spelling | doaj.art-a6af3f202b2240378a96f91ed6ebb16f2022-12-22T03:37:56ZengPAGEPress PublicationsArchivio Italiano di Urologia e Andrologia1124-35622282-41972022-06-0194210.4081/aiua.2022.2.252Effect of alpha-adrenoceptor antagonists on sexual function. A systematic review and meta-analysisRawa Bapir0Kamran Hassan Bhatti1Ahmed Eliwa2Herney Andrés García-Perdomo3Nazim Gherabi4Derek Hennessey5Vittorio Magri6Panagiotis Mourmouris7Adama Ouattara8Gianpaolo Perletti9Joseph Philipraj10Alberto Trinchieri11Noor Buchholz12U-merge Ltd. (Urology for emerging countries), London-Athens-Dubai; and Smart Health Tower, Sulaymaniyah, Kurdistan regionU-merge Ltd. (Urology for emerging countries), London-Athens-Dubai; and Urology Department, HMC, Hamad Medical CorporationU-merge Ltd. (Urology for emerging countries), London-Athens-Dubai; and Department of Urology, Zagazig University, Zagazig, SharkiaU-merge Ltd. (Urology for emerging countries), London-Athens-Dubai; Universidad del Valle, CaliU-merge Ltd. (Urology for emerging countries), London-Athens-Dubai; and Faculty of Medicine Algiers 1, AlgiersU-merge Ltd. (Urology for emerging countries), London-Athens-Dubai; and Department of Urology, Mercy University Hospital, CorkU-merge Ltd. (Urology for emerging countries), London-Athens-Dubai; and ASST Nord Milano, MilanU-merge Ltd. (Urology for emerging countries), London-Athens-Dubai; and 2nd Department of Urology, National and Kapodistrian University of Athens, Sismanoglio Hospital, AthensU-merge Ltd. (Urology for emerging countries), London-Athens-Dubai; and Division of Urology, Souro Sanou University Teaching Hospital, Bobo-DioulassoU-merge Ltd. (Urology for emerging countries), London-Athens-Dubai; and Department of Biotechnology and Life Sciences, Section of Medical and Surgical Sciences, University of Insubria, VareseU-merge Ltd. (Urology for emerging countries), London-Athens-Dubai; and Department of Urology, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth, PuducherryU-merge Ltd. (Urology for emerging countries), London-Athens-Dubai; and Urology School, University of MilanU-merge Ltd. (Urology for emerging countries), London-Athens-Dubai; and Sobeh's Vascular and Medical Center, Dubai Health Care City, Dubai Background: Alpha-adrenoreceptor antagonists or alpha-blockers are used in the treatment of hypertension, in the therapy of benign prostatic hyperplasia and in medical expulsive treatment of ureteral stones. These agents may affect the sexual function, with differences between drugs within the same class, depending on their selectivity for receptor subtypes. The aim of this review was to analyze the effects of alpha-blockers on sexual function. Materials and methods: We conducted a systematic review and meta-analysis by searching PubMed, EMBASE and other databases for randomized controlled trials (RCTs) reporting sexual adverse effects in patients treated with alpha-blockers. Odds ratios for sexual dysfunction were calculated using random effects Mantel-Haenszel statistics. Results: Out of 608 records retrieved, 75 eligible RCTs were included in the meta-analysis. Compared with placebo, alphablockers were associated with increased odds of ejaculatory disorders both in patients with lower urinary tract symptoms (LUTS) associated to benign prostatic hyperplasia (BPH) (OR: 7.53, 95% CI: 3.77-15.02, Z = 5.73, p < 0.00001, I2 = 55%) and in patients with ureteral stones (OR: 2.88, 95% CI: 1.50-5.44, Z = 3.19, p < 0.001, I2 = 31%). Uroselective alpha-blockers showed higher odds of ejaculatory disorders. Conversely, nonselective alpha-blockers were not associated with higher odds of ejaculatory dysfunction. Silodosin was associated with increased odds of ejaculatory dysfunction compared with tamsulosin (OR: 3.52, 95% CI: 2.18-5.68, 15 series, 1512 participants, Z = 5.15, p < 0.00001, I2 = 0%). Naftopidil and alfuzosin showed lower odds of ejaculatory dysfunction compared to uroselective alpha-blockers.No statistically significant differences in the odds of erectile dysfunction were observed when alpha-blockers were compared to placebo. https://www.pagepressjournals.org/index.php/aiua/article/view/10711Alpha-blockers; Ejaculation; Erectile dysfunction; Silodosin; Tamsulosin; Alfuzosin; Doxazosin; Terazosin |
| spellingShingle | Rawa Bapir Kamran Hassan Bhatti Ahmed Eliwa Herney Andrés García-Perdomo Nazim Gherabi Derek Hennessey Vittorio Magri Panagiotis Mourmouris Adama Ouattara Gianpaolo Perletti Joseph Philipraj Alberto Trinchieri Noor Buchholz Effect of alpha-adrenoceptor antagonists on sexual function. A systematic review and meta-analysis Archivio Italiano di Urologia e Andrologia Alpha-blockers; Ejaculation; Erectile dysfunction; Silodosin; Tamsulosin; Alfuzosin; Doxazosin; Terazosin |
| title | Effect of alpha-adrenoceptor antagonists on sexual function. A systematic review and meta-analysis |
| title_full | Effect of alpha-adrenoceptor antagonists on sexual function. A systematic review and meta-analysis |
| title_fullStr | Effect of alpha-adrenoceptor antagonists on sexual function. A systematic review and meta-analysis |
| title_full_unstemmed | Effect of alpha-adrenoceptor antagonists on sexual function. A systematic review and meta-analysis |
| title_short | Effect of alpha-adrenoceptor antagonists on sexual function. A systematic review and meta-analysis |
| title_sort | effect of alpha adrenoceptor antagonists on sexual function a systematic review and meta analysis |
| topic | Alpha-blockers; Ejaculation; Erectile dysfunction; Silodosin; Tamsulosin; Alfuzosin; Doxazosin; Terazosin |
| url | https://www.pagepressjournals.org/index.php/aiua/article/view/10711 |
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