Lumbricus Extract Prevents LPS-Induced Inflammatory Activation of BV2 Microglia and Glutamate-Induced Hippocampal HT22 Cell Death by Suppressing MAPK/NF-κB/NLRP3 Signaling and Oxidative Stress

Lumbricus Extract Prevents LPS-Induced Inflammatory Activation of BV2 Microglia and Glutamate-Induced Hippocampal HT22 Cell Death by Suppressing MAPK/NF-κB/NLRP3 Signaling and Oxidative Stress

Microglia-induced inflammatory signaling and neuronal oxidative stress are mutually reinforcing processes central to the pathogenesis of neurodegenerative diseases. Recent studies have shown that extracts of dried <i>Pheretima aspergillum</i> (Lumbricus) can inhibit tissue fibrosis, mito...

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Bibliographic Details
Main Authors: You-Chang Oh, Yun Hee Jeong, Hye Jin Yang, Wei Li, Jin Yeul Ma
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Current Issues in Molecular Biology
Subjects:
Lumbricus
anti-neuroinflammation
neuroprotective effects
antioxidant
anti-apoptosis
Online Access:https://www.mdpi.com/1467-3045/45/12/620

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