Added Value of Rescue Devices in Intra-Arterial Thrombectomy: When Should We Apply Them?
Introduction: Recent trials have demonstrated the superior efficacy of mechanical thrombectomy over other medical treatments for acute ischemic stroke; however, not every large vessel occlusion (LVO) can be recanalized using a single thrombectomy device. Rescue devices were proved to increase the re...
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| Format: | Article |
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2021.689606/full |
| _version_ | 1818729278061150208 |
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| author | Cheng-Fu Ni Sho-Jen Cheng Cheng-Yu Chen Cheng-Yu Chen Cheng-Yu Chen Tu-Hsueh Yeh Tu-Hsueh Yeh Kevin Li-Chun Hsieh Kevin Li-Chun Hsieh Kevin Li-Chun Hsieh |
| author_facet | Cheng-Fu Ni Sho-Jen Cheng Cheng-Yu Chen Cheng-Yu Chen Cheng-Yu Chen Tu-Hsueh Yeh Tu-Hsueh Yeh Kevin Li-Chun Hsieh Kevin Li-Chun Hsieh Kevin Li-Chun Hsieh |
| author_sort | Cheng-Fu Ni |
| collection | DOAJ |
| description | Introduction: Recent trials have demonstrated the superior efficacy of mechanical thrombectomy over other medical treatments for acute ischemic stroke; however, not every large vessel occlusion (LVO) can be recanalized using a single thrombectomy device. Rescue devices were proved to increase the reperfusion rate, but the efficacy is unclear.Objective: In this retrospective study, we evaluated the efficacy of rescue therapy in different locations of LVO.Methods: We analyzed the outcomes of mechanical thrombectomy from a prospective registry of consecutive 82 patients in Taipei Medical University Hospital. The reperfusion rate and the functional outcome were compared in patients who received first-line therapy only and patients who need rescue therapy.Results: An 84.1% reperfusion rate was achieved in our cohort. We applied first-line stent retriever (SR) treatment in 6 patients, among which 4 (66.6%) achieved successful reperfusion. We applied a direct-aspiration first-pass technique (ADAPT) as the first-line treatment in 76 patients, among which 46 (60.5%) achieved successful reperfusion. Successful reperfusion could not be achieved in 30 cases (39.5%); therefore, we applied a second-line rescue SR for 28 patients, and reperfusion was established in 18 (64.3%) of them. These results revealed that the LVO in anterior circulation has a higher chance to respond to SR rescue therapy than posterior circulation lesions (68 vs. 33.3%, P < 0.001). Patients who received only first-line therapy exhibited significantly better functional outcomes than those who were also treated with rescue SR therapy (41.2 vs. 16.7%, P = 0.001). In addition, patients with LVO in the anterior circulation were found to have a higher probability of achieving functional independence than patients with posterior circulation lesions (10.7 vs. 0.0%, P < 0.001). The adjusted multivariate analysis revealed that successful reperfusion and treatment type (first-line or rescue therapy) were significantly related to a modified Rankin Scale (mRS) score at 90 days.Conclusion: This study reveals that rescue SR therapy improves the reperfusion rate. Patients who require rescue SR therapy have a lower likelihood of functional independence. LVO in the anterior circulation responds better to rescue SR therapy and results in better functional outcomes than posterior circulation lesions. |
| first_indexed | 2024-12-17T22:43:20Z |
| format | Article |
| id | doaj.art-a6b234dad3f34062901df4f3bbc0fe5d |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-17T22:43:20Z |
| publishDate | 2021-08-01 |
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| series | Frontiers in Neurology |
| spelling | doaj.art-a6b234dad3f34062901df4f3bbc0fe5d2022-12-21T21:29:51ZengFrontiers Media S.A.Frontiers in Neurology1664-22952021-08-011210.3389/fneur.2021.689606689606Added Value of Rescue Devices in Intra-Arterial Thrombectomy: When Should We Apply Them?Cheng-Fu Ni0Sho-Jen Cheng1Cheng-Yu Chen2Cheng-Yu Chen3Cheng-Yu Chen4Tu-Hsueh Yeh5Tu-Hsueh Yeh6Kevin Li-Chun Hsieh7Kevin Li-Chun Hsieh8Kevin Li-Chun Hsieh9Department of Medical Imaging, Taipei Medical University Hospital, Taipei, TaiwanDepartment of Medical Imaging, Taipei Medical University Hospital, Taipei, TaiwanDepartment of Medical Imaging, Taipei Medical University Hospital, Taipei, TaiwanResearch Center of Translational Imaging, College of Medicine, Taipei Medical University, Taipei, TaiwanDepartment of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanDepartment of Neurology, Taipei Medical University Hospital, Taipei, TaiwanTaipei Neuroscience Institute, Taipei Medical University, Taipei, TaiwanDepartment of Medical Imaging, Taipei Medical University Hospital, Taipei, TaiwanResearch Center of Translational Imaging, College of Medicine, Taipei Medical University, Taipei, TaiwanDepartment of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanIntroduction: Recent trials have demonstrated the superior efficacy of mechanical thrombectomy over other medical treatments for acute ischemic stroke; however, not every large vessel occlusion (LVO) can be recanalized using a single thrombectomy device. Rescue devices were proved to increase the reperfusion rate, but the efficacy is unclear.Objective: In this retrospective study, we evaluated the efficacy of rescue therapy in different locations of LVO.Methods: We analyzed the outcomes of mechanical thrombectomy from a prospective registry of consecutive 82 patients in Taipei Medical University Hospital. The reperfusion rate and the functional outcome were compared in patients who received first-line therapy only and patients who need rescue therapy.Results: An 84.1% reperfusion rate was achieved in our cohort. We applied first-line stent retriever (SR) treatment in 6 patients, among which 4 (66.6%) achieved successful reperfusion. We applied a direct-aspiration first-pass technique (ADAPT) as the first-line treatment in 76 patients, among which 46 (60.5%) achieved successful reperfusion. Successful reperfusion could not be achieved in 30 cases (39.5%); therefore, we applied a second-line rescue SR for 28 patients, and reperfusion was established in 18 (64.3%) of them. These results revealed that the LVO in anterior circulation has a higher chance to respond to SR rescue therapy than posterior circulation lesions (68 vs. 33.3%, P < 0.001). Patients who received only first-line therapy exhibited significantly better functional outcomes than those who were also treated with rescue SR therapy (41.2 vs. 16.7%, P = 0.001). In addition, patients with LVO in the anterior circulation were found to have a higher probability of achieving functional independence than patients with posterior circulation lesions (10.7 vs. 0.0%, P < 0.001). The adjusted multivariate analysis revealed that successful reperfusion and treatment type (first-line or rescue therapy) were significantly related to a modified Rankin Scale (mRS) score at 90 days.Conclusion: This study reveals that rescue SR therapy improves the reperfusion rate. Patients who require rescue SR therapy have a lower likelihood of functional independence. LVO in the anterior circulation responds better to rescue SR therapy and results in better functional outcomes than posterior circulation lesions.https://www.frontiersin.org/articles/10.3389/fneur.2021.689606/fullintra-arterial thrombectomystrokerescuethrombosuctionstent retreiverlarge vessel occlusion |
| spellingShingle | Cheng-Fu Ni Sho-Jen Cheng Cheng-Yu Chen Cheng-Yu Chen Cheng-Yu Chen Tu-Hsueh Yeh Tu-Hsueh Yeh Kevin Li-Chun Hsieh Kevin Li-Chun Hsieh Kevin Li-Chun Hsieh Added Value of Rescue Devices in Intra-Arterial Thrombectomy: When Should We Apply Them? Frontiers in Neurology intra-arterial thrombectomy stroke rescue thrombosuction stent retreiver large vessel occlusion |
| title | Added Value of Rescue Devices in Intra-Arterial Thrombectomy: When Should We Apply Them? |
| title_full | Added Value of Rescue Devices in Intra-Arterial Thrombectomy: When Should We Apply Them? |
| title_fullStr | Added Value of Rescue Devices in Intra-Arterial Thrombectomy: When Should We Apply Them? |
| title_full_unstemmed | Added Value of Rescue Devices in Intra-Arterial Thrombectomy: When Should We Apply Them? |
| title_short | Added Value of Rescue Devices in Intra-Arterial Thrombectomy: When Should We Apply Them? |
| title_sort | added value of rescue devices in intra arterial thrombectomy when should we apply them |
| topic | intra-arterial thrombectomy stroke rescue thrombosuction stent retreiver large vessel occlusion |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2021.689606/full |
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