CD4+c-Met+Itgα4+ T cell subset promotes murine neuroinflammation

CD4+c-Met+Itgα4+ T cell subset promotes murine neuroinflammation

Abstract Objective c-Met, a tyrosine kinase receptor, is the unique receptor for hepatocyte growth factor (HGF). The HGF/c-Met axis is reported to modulate cell migration, maturation, cytokine production, and antigen presentation. Here, we report that CD4+c-Met+ T cells are detected at increased lev...

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Bibliographic Details
Main Authors: Mahdia Benkhoucha, Ngoc Lan Tran, Gautier Breville, Isis Senoner, Paul F. Bradfield, Thalia Papayannopoulou, Doron Merkler, Thomas Korn, Patrice H. Lalive
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Journal of Neuroinflammation
Subjects:
c-Met
HGF
T lymphocytes
Integrin
Transmigration
Neuroinflammation
Online Access:https://doi.org/10.1186/s12974-022-02461-7

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