Assessment of longitudinal distribution of subclinical atherosclerosis in femoral arteries by three-dimensional cardiovascular magnetic resonance vessel wall imaging
Abstract Background Lower extremity peripheral artery disease has become a significant health burden worldwide. Since the treatment strategies can be different if atherosclerotic disease involves different femoral artery segments, it is important to assess plaque distribution among different segment...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-09-01
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| Series: | Journal of Cardiovascular Magnetic Resonance |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12968-018-0482-7 |
| _version_ | 1797204480129761280 |
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| author | Yongjun Han Maobin Guan Zhu Zhu Dongye Li Huijun Chen Chun Yuan Cheng Li Wei Wang Xihai Zhao |
| author_facet | Yongjun Han Maobin Guan Zhu Zhu Dongye Li Huijun Chen Chun Yuan Cheng Li Wei Wang Xihai Zhao |
| author_sort | Yongjun Han |
| collection | DOAJ |
| description | Abstract Background Lower extremity peripheral artery disease has become a significant health burden worldwide. Since the treatment strategies can be different if atherosclerotic disease involves different femoral artery segments, it is important to assess plaque distribution among different segments of femoral arteries. We sought to investigate the longitudinal distribution of subclinical femoral artery atherosclerosis in asymptomatic elderly adults using cardiovascular magnetic resonance (CMR) vessel wall imaging. Methods Asymptomatic elderly subjects underwent three-dimensional (3D) CMR vessel wall imaging for femoral arteries. The 3D motion sensitized-driven equilibrium prepared rapid gradient-echo (3D-MERGE) sequence was acquired from the common femoral artery to the popliteal artery. The femoral artery was divided into 4 segments: common femoral artery (CFA), proximal superficial femoral artery (pSFA), adductor canal (AC) segment of femoral artery, and popliteal artery (PA). The morphological characteristics including lumen area, wall area, maximum and minimum wall thickness, normalized wall index (NWI = wall area / [lumen area + wall area] × 100%), and eccentricity index ([maximum wall thickness - minimum wall thickness] / maximum wall thickness), luminal stenosis, and presence of atherosclerotic plaque were evaluated and compared between bilateral sides and among different femoral artery segments in each side of femoral artery. The associations between ankle-brachial index (ABI) and cardiovascular risk factors and femoral artery plaque characteristics were also determined. Results Of 107 recruited subjects (71.9 ± 5.6 years; 48 males), 70 (65.4%) were found to have femoral artery plaques. The atherosclerotic plaques were most frequently found in PA (41.1%) and CFA (40.2%) segments, followed by pSFA (31.8%) and AC (23.4%) segments (p = 0.002). Similarly, PA and CFA segments showed significantly greater maximum wall thickness and eccentricity index compared with pSFA and AC segments (all p < 0.001). Significant differences can be found in NWI among four segments of femoral arteries (p < 0.001) and PA showed the highest NWI (54.8%), followed by AC (54.3%), pSFA (52.4%) and CFA (45.9%) segments. Compared with right femoral artery, left femoral artery had significant smaller lumen area and greater NWI in most of segments (p < 0.002). There were no significant differences in ABI between subjects with and without atherosclerotic plaques (p = 0.161). The presence of subclinical atherosclerotic plaque in femoral arteries was significantly associated with cardiovascular risk factors including age (odds ratio [OR], 1.133; 95% confidence interval [CI], 1.048–1.224, p = 0.002), male gender (OR, 3.914; 95% CI, 1.612–9.501, p = 0.003), and hypertension (OR, 4.000; 95% CI, 1.700–9.411, p = 0.001), respectively. Conclusions Subclinical femoral artery atherosclerosis is prevalent in the elderly population, particularly in the left femoral artery and segments of CFA and PA, and is associated with age, male gender and hypertension. Our findings suggest that, for screening subclinical atherosclerosis, more attention needs to be paid to the specific side and segments of femoral arteries, particularly older individuals and those with these cardiovascular disease risk factors. |
| first_indexed | 2024-04-24T08:35:54Z |
| format | Article |
| id | doaj.art-a6b38445f09c43359c9e48c7edaf81b5 |
| institution | Directory Open Access Journal |
| issn | 1532-429X |
| language | English |
| last_indexed | 2024-04-24T08:35:54Z |
| publishDate | 2018-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Cardiovascular Magnetic Resonance |
| spelling | doaj.art-a6b38445f09c43359c9e48c7edaf81b52024-04-16T17:32:04ZengElsevierJournal of Cardiovascular Magnetic Resonance1532-429X2018-09-0120111010.1186/s12968-018-0482-7Assessment of longitudinal distribution of subclinical atherosclerosis in femoral arteries by three-dimensional cardiovascular magnetic resonance vessel wall imagingYongjun Han0Maobin Guan1Zhu Zhu2Dongye Li3Huijun Chen4Chun Yuan5Cheng Li6Wei Wang7Xihai Zhao8Center for Brain Disorders Research, Capital Medical University and Beijing Institute of Brain DisordersDepartment of Radiology, The Affiliated Hospital of Yangzhou University, Yangzhou UniversityDepartment of Radiology, The Affiliated Hospital of Yangzhou University, Yangzhou UniversityCenter for Brain Disorders Research, Capital Medical University and Beijing Institute of Brain DisordersCenter for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University School of MedicineCenter for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University School of MedicineDepartment of Radiology, Zhongda Hospital, Medical School of Southeast UniversityDepartment of Radiology, The Affiliated Hospital of Yangzhou University, Yangzhou UniversityCenter for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University School of MedicineAbstract Background Lower extremity peripheral artery disease has become a significant health burden worldwide. Since the treatment strategies can be different if atherosclerotic disease involves different femoral artery segments, it is important to assess plaque distribution among different segments of femoral arteries. We sought to investigate the longitudinal distribution of subclinical femoral artery atherosclerosis in asymptomatic elderly adults using cardiovascular magnetic resonance (CMR) vessel wall imaging. Methods Asymptomatic elderly subjects underwent three-dimensional (3D) CMR vessel wall imaging for femoral arteries. The 3D motion sensitized-driven equilibrium prepared rapid gradient-echo (3D-MERGE) sequence was acquired from the common femoral artery to the popliteal artery. The femoral artery was divided into 4 segments: common femoral artery (CFA), proximal superficial femoral artery (pSFA), adductor canal (AC) segment of femoral artery, and popliteal artery (PA). The morphological characteristics including lumen area, wall area, maximum and minimum wall thickness, normalized wall index (NWI = wall area / [lumen area + wall area] × 100%), and eccentricity index ([maximum wall thickness - minimum wall thickness] / maximum wall thickness), luminal stenosis, and presence of atherosclerotic plaque were evaluated and compared between bilateral sides and among different femoral artery segments in each side of femoral artery. The associations between ankle-brachial index (ABI) and cardiovascular risk factors and femoral artery plaque characteristics were also determined. Results Of 107 recruited subjects (71.9 ± 5.6 years; 48 males), 70 (65.4%) were found to have femoral artery plaques. The atherosclerotic plaques were most frequently found in PA (41.1%) and CFA (40.2%) segments, followed by pSFA (31.8%) and AC (23.4%) segments (p = 0.002). Similarly, PA and CFA segments showed significantly greater maximum wall thickness and eccentricity index compared with pSFA and AC segments (all p < 0.001). Significant differences can be found in NWI among four segments of femoral arteries (p < 0.001) and PA showed the highest NWI (54.8%), followed by AC (54.3%), pSFA (52.4%) and CFA (45.9%) segments. Compared with right femoral artery, left femoral artery had significant smaller lumen area and greater NWI in most of segments (p < 0.002). There were no significant differences in ABI between subjects with and without atherosclerotic plaques (p = 0.161). The presence of subclinical atherosclerotic plaque in femoral arteries was significantly associated with cardiovascular risk factors including age (odds ratio [OR], 1.133; 95% confidence interval [CI], 1.048–1.224, p = 0.002), male gender (OR, 3.914; 95% CI, 1.612–9.501, p = 0.003), and hypertension (OR, 4.000; 95% CI, 1.700–9.411, p = 0.001), respectively. Conclusions Subclinical femoral artery atherosclerosis is prevalent in the elderly population, particularly in the left femoral artery and segments of CFA and PA, and is associated with age, male gender and hypertension. Our findings suggest that, for screening subclinical atherosclerosis, more attention needs to be paid to the specific side and segments of femoral arteries, particularly older individuals and those with these cardiovascular disease risk factors.http://link.springer.com/article/10.1186/s12968-018-0482-7Femoral arteryAtherosclerosisPeripheral artery diseaseDistributionMagnetic resonance imaging |
| spellingShingle | Yongjun Han Maobin Guan Zhu Zhu Dongye Li Huijun Chen Chun Yuan Cheng Li Wei Wang Xihai Zhao Assessment of longitudinal distribution of subclinical atherosclerosis in femoral arteries by three-dimensional cardiovascular magnetic resonance vessel wall imaging Journal of Cardiovascular Magnetic Resonance Femoral artery Atherosclerosis Peripheral artery disease Distribution Magnetic resonance imaging |
| title | Assessment of longitudinal distribution of subclinical atherosclerosis in femoral arteries by three-dimensional cardiovascular magnetic resonance vessel wall imaging |
| title_full | Assessment of longitudinal distribution of subclinical atherosclerosis in femoral arteries by three-dimensional cardiovascular magnetic resonance vessel wall imaging |
| title_fullStr | Assessment of longitudinal distribution of subclinical atherosclerosis in femoral arteries by three-dimensional cardiovascular magnetic resonance vessel wall imaging |
| title_full_unstemmed | Assessment of longitudinal distribution of subclinical atherosclerosis in femoral arteries by three-dimensional cardiovascular magnetic resonance vessel wall imaging |
| title_short | Assessment of longitudinal distribution of subclinical atherosclerosis in femoral arteries by three-dimensional cardiovascular magnetic resonance vessel wall imaging |
| title_sort | assessment of longitudinal distribution of subclinical atherosclerosis in femoral arteries by three dimensional cardiovascular magnetic resonance vessel wall imaging |
| topic | Femoral artery Atherosclerosis Peripheral artery disease Distribution Magnetic resonance imaging |
| url | http://link.springer.com/article/10.1186/s12968-018-0482-7 |
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