Association between CHA2DS2-VASc score and in-hospital death in ICU patients with COVID-19
Background: CHA2DS2-VASc score is a scientifically proven risk assessment score for patients with atrial fibrillation. It may be a good predictor of in-hospital death in COVID-19 patients. The present study aimed to evaluate the association between CHA2DS2-VASc score and in-hospital mortality in the...
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| Format: | Article |
| Language: | English |
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Journal of Ideas in Health
2021-11-01
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| Series: | Journal of Ideas in Health |
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| Online Access: | https://www.jidhealth.com/index.php/jidhealth/article/view/173 |
| _version_ | 1797909577148137472 |
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| author | Mukesh Jha Utkarsh Mukesh Balani Vimlesh Pandey Prachi Balani Vipin Patel Abhishek Mehta |
| author_facet | Mukesh Jha Utkarsh Mukesh Balani Vimlesh Pandey Prachi Balani Vipin Patel Abhishek Mehta |
| author_sort | Mukesh Jha |
| collection | DOAJ |
| description | Background: CHA2DS2-VASc score is a scientifically proven risk assessment score for patients with atrial fibrillation. It may be a good predictor of in-hospital death in COVID-19 patients. The present study aimed to evaluate the association between CHA2DS2-VASc score and in-hospital mortality in the prognosis of intensive care unit (ICU) patients with COVID-19.
Methods: Eighty-four COVID-19 patients who were hospitalized in the ICU were retrospectively analyzed in a tertiary health care center, and the CHA2DS2-VASc score was determined. All analyses were performed using SPSS statistical software (SPSS Inc., Chicago, IL, USA, 20.0). A p-value <0.05 was considered statistically significant.
Results: The median age of patients was 60.0 years, and most were males (75.0%). Findings of the study showed that the CHA2DS2-VASc score was considerably higher among the hospitalized patients than discharged patients (3.08 ± 1.72 vs. 1.38 ± 1.16; p<0.001), and patients who required mechanical ventilation compared to those who did not require mechanical ventilation (3.03 ± 1.68 vs. 1.15 ± 0.97; P <0.001), respectively. Patients with CHA2DS2-VASc score of ≥3 had substantially higher age [67(45-87) vs. 58(19-75); P ˂0.001], computed tomography involvement score [67.5(20-90) vs. 35(15-90); P ˂0.001] and need for mechanical ventilation [29(90.6%) vs. 22(42.3%); P ˂0.001]. A significant difference was found in oxygen saturation on admission (P =0.001) between the two groups. In-hospital death was significantly higher among patients with a CHA2DS2-VASc score of ≥3 (P <0.001). The CHA2DS2-VASc score was positively correlated with white blood cells count (r=0.257, P =0.018) and negatively correlated with the number of days spent in the hospital (r=-0.184, P=0.130) due to higher in-hospital death in ICU patients with COVID-19.
Conclusion: CHA2DS2-VASc score may be an effective tool to estimate in-hospital death in COVID-19 patients who were hospitalized in the ICU. |
| first_indexed | 2024-04-10T11:11:25Z |
| format | Article |
| id | doaj.art-a6b3af84d6bf4947b78579a35f631f82 |
| institution | Directory Open Access Journal |
| issn | 2645-9248 |
| language | English |
| last_indexed | 2024-04-10T11:11:25Z |
| publishDate | 2021-11-01 |
| publisher | Journal of Ideas in Health |
| record_format | Article |
| series | Journal of Ideas in Health |
| spelling | doaj.art-a6b3af84d6bf4947b78579a35f631f822023-02-15T16:19:08ZengJournal of Ideas in HealthJournal of Ideas in Health2645-92482021-11-014410.47108/jidhealth.Vol4.Iss4.173Association between CHA2DS2-VASc score and in-hospital death in ICU patients with COVID-19Mukesh Jha0Utkarsh Mukesh Balani1Vimlesh Pandey2Prachi Balani3Vipin Patel4Abhishek Mehta5Department of Cardiology, Sri Aurobindo Medical College and PG Institute, Indore-Ujjain State Highway, Indore, Madhya Pradesh-433555, IndiaDepartment of General Medicine, Sri Aurobindo Medical College and PG Institute, Indore-Ujjain State Highway, Indore, Madhya Pradesh-433555, IndiaDepartment of Cardiology, Sri Aurobindo Medical College and PG Institute, Indore-Ujjain State Highway, Indore, Madhya Pradesh-433555, IndiaDepartment of Cardiology, AMC Met Medical College, Bhairavnath, Maninagar, Ahmedabad, Gujarat-380008, IndiaDepartment of General Medicine, Sri Aurobindo Medical College and PG institute, Indore-Ujjain State Highway, Indore, Madhya Pradesh-433555, IndiaDepartment of General Medicine, Sri Aurobindo Medical College and PG institute, Indore-Ujjain State Highway, Indore, Madhya Pradesh-433555, IndiaBackground: CHA2DS2-VASc score is a scientifically proven risk assessment score for patients with atrial fibrillation. It may be a good predictor of in-hospital death in COVID-19 patients. The present study aimed to evaluate the association between CHA2DS2-VASc score and in-hospital mortality in the prognosis of intensive care unit (ICU) patients with COVID-19. Methods: Eighty-four COVID-19 patients who were hospitalized in the ICU were retrospectively analyzed in a tertiary health care center, and the CHA2DS2-VASc score was determined. All analyses were performed using SPSS statistical software (SPSS Inc., Chicago, IL, USA, 20.0). A p-value <0.05 was considered statistically significant. Results: The median age of patients was 60.0 years, and most were males (75.0%). Findings of the study showed that the CHA2DS2-VASc score was considerably higher among the hospitalized patients than discharged patients (3.08 ± 1.72 vs. 1.38 ± 1.16; p<0.001), and patients who required mechanical ventilation compared to those who did not require mechanical ventilation (3.03 ± 1.68 vs. 1.15 ± 0.97; P <0.001), respectively. Patients with CHA2DS2-VASc score of ≥3 had substantially higher age [67(45-87) vs. 58(19-75); P ˂0.001], computed tomography involvement score [67.5(20-90) vs. 35(15-90); P ˂0.001] and need for mechanical ventilation [29(90.6%) vs. 22(42.3%); P ˂0.001]. A significant difference was found in oxygen saturation on admission (P =0.001) between the two groups. In-hospital death was significantly higher among patients with a CHA2DS2-VASc score of ≥3 (P <0.001). The CHA2DS2-VASc score was positively correlated with white blood cells count (r=0.257, P =0.018) and negatively correlated with the number of days spent in the hospital (r=-0.184, P=0.130) due to higher in-hospital death in ICU patients with COVID-19. Conclusion: CHA2DS2-VASc score may be an effective tool to estimate in-hospital death in COVID-19 patients who were hospitalized in the ICU.https://www.jidhealth.com/index.php/jidhealth/article/view/173COVID-19, CHA2DS2-VASc, In-Hospital Death, Intensive Care Unit, SARS-CoV-2, India |
| spellingShingle | Mukesh Jha Utkarsh Mukesh Balani Vimlesh Pandey Prachi Balani Vipin Patel Abhishek Mehta Association between CHA2DS2-VASc score and in-hospital death in ICU patients with COVID-19 Journal of Ideas in Health COVID-19, CHA2DS2-VASc, In-Hospital Death, Intensive Care Unit, SARS-CoV-2, India |
| title | Association between CHA2DS2-VASc score and in-hospital death in ICU patients with COVID-19 |
| title_full | Association between CHA2DS2-VASc score and in-hospital death in ICU patients with COVID-19 |
| title_fullStr | Association between CHA2DS2-VASc score and in-hospital death in ICU patients with COVID-19 |
| title_full_unstemmed | Association between CHA2DS2-VASc score and in-hospital death in ICU patients with COVID-19 |
| title_short | Association between CHA2DS2-VASc score and in-hospital death in ICU patients with COVID-19 |
| title_sort | association between cha2ds2 vasc score and in hospital death in icu patients with covid 19 |
| topic | COVID-19, CHA2DS2-VASc, In-Hospital Death, Intensive Care Unit, SARS-CoV-2, India |
| url | https://www.jidhealth.com/index.php/jidhealth/article/view/173 |
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