Can RNA Affect Memory Modulation? Implications for PTSD Understanding and Treatment
Memories are a central aspect of our lives, but the mechanisms underlying their formation, consolidation, retrieval, and extinction remain poorly understood. In this review, we explore the molecular mechanisms of memory modulation and investigate the effects of RNA on these processes. Specifically,...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/16/12908 |
| _version_ | 1797584430349418496 |
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| author | Tehila Cohen Noam Shomron |
| author_facet | Tehila Cohen Noam Shomron |
| author_sort | Tehila Cohen |
| collection | DOAJ |
| description | Memories are a central aspect of our lives, but the mechanisms underlying their formation, consolidation, retrieval, and extinction remain poorly understood. In this review, we explore the molecular mechanisms of memory modulation and investigate the effects of RNA on these processes. Specifically, we examine the effects of time and location on gene expression alterations. We then discuss the potential for harnessing these alterations to modulate memories, particularly fear memories, to alleviate post-traumatic stress disorder (PTSD) symptoms. The current state of research suggests that transcriptional changes play a major role in memory modulation and targeting them through microRNAs may hold promise as a novel approach for treating memory-related disorders such as PTSD. |
| first_indexed | 2024-03-10T23:52:35Z |
| format | Article |
| id | doaj.art-a6b46c4029d04bf1a371e9b2f42fd212 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T23:52:35Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-a6b46c4029d04bf1a371e9b2f42fd2122023-11-19T01:32:00ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-08-0124161290810.3390/ijms241612908Can RNA Affect Memory Modulation? Implications for PTSD Understanding and TreatmentTehila Cohen0Noam Shomron1Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, IsraelFaculty of Medicine, Tel Aviv University, Tel Aviv 6997801, IsraelMemories are a central aspect of our lives, but the mechanisms underlying their formation, consolidation, retrieval, and extinction remain poorly understood. In this review, we explore the molecular mechanisms of memory modulation and investigate the effects of RNA on these processes. Specifically, we examine the effects of time and location on gene expression alterations. We then discuss the potential for harnessing these alterations to modulate memories, particularly fear memories, to alleviate post-traumatic stress disorder (PTSD) symptoms. The current state of research suggests that transcriptional changes play a major role in memory modulation and targeting them through microRNAs may hold promise as a novel approach for treating memory-related disorders such as PTSD.https://www.mdpi.com/1422-0067/24/16/12908memorytranscriptionRNAmicroRNAPTSD |
| spellingShingle | Tehila Cohen Noam Shomron Can RNA Affect Memory Modulation? Implications for PTSD Understanding and Treatment International Journal of Molecular Sciences memory transcription RNA microRNA PTSD |
| title | Can RNA Affect Memory Modulation? Implications for PTSD Understanding and Treatment |
| title_full | Can RNA Affect Memory Modulation? Implications for PTSD Understanding and Treatment |
| title_fullStr | Can RNA Affect Memory Modulation? Implications for PTSD Understanding and Treatment |
| title_full_unstemmed | Can RNA Affect Memory Modulation? Implications for PTSD Understanding and Treatment |
| title_short | Can RNA Affect Memory Modulation? Implications for PTSD Understanding and Treatment |
| title_sort | can rna affect memory modulation implications for ptsd understanding and treatment |
| topic | memory transcription RNA microRNA PTSD |
| url | https://www.mdpi.com/1422-0067/24/16/12908 |
| work_keys_str_mv | AT tehilacohen canrnaaffectmemorymodulationimplicationsforptsdunderstandingandtreatment AT noamshomron canrnaaffectmemorymodulationimplicationsforptsdunderstandingandtreatment |