Clinical Profile, Outcome, and Short-Term Follow-up of Pediatric Multisystem Inflammatory Syndrome Cases in a Tertiary Care Center of Western India
Background: There are several reports of the pediatric multisystem inflammatory syndrome associated with COVID-19 in children globally. The current Indian data on PIMS-TS associated with COVID-19 are scarce. Aims and Objectives: To describe demographic, clinical and laboratory findings, management,...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-01-01
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| Series: | APIK Journal of Internal Medicine |
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| Online Access: | http://www.ajim.in/article.asp?issn=2666-1802;year=2024;volume=12;issue=1;spage=46;epage=50;aulast=Nagadia |
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| author | Qury Nagadia Ghosha Nilesh Pandav Nidhi Dhamecha Suhani Patel Anurag Gupta Nehal Patel |
| author_facet | Qury Nagadia Ghosha Nilesh Pandav Nidhi Dhamecha Suhani Patel Anurag Gupta Nehal Patel |
| author_sort | Qury Nagadia |
| collection | DOAJ |
| description | Background: There are several reports of the pediatric multisystem inflammatory syndrome associated with COVID-19 in children globally. The current Indian data on PIMS-TS associated with COVID-19 are scarce. Aims and Objectives: To describe demographic, clinical and laboratory findings, management, and follow - up of cases of PIMS-TS. Materials and Method: We analyzed children presenting to our hospital from July 2020 to January 2021, with PIMS-TS. Cases were categorized into two subsets: Group 1 (MIS-C with shock) and Group 2 (MIS-C without shock). Coronary Z scores of >2.5 were considered as dilated. We followed all the patients at 15 days, 3 months, 6 months, and 12 months. Results: Total 11 patients with diagnosis of MIS-C were treated during this study period. Mean age of presentation was 6.5 years. All patients in Group 1 needed inotropic support and treated with steroids and intravenous immunoglobulin. Three patients required administration of tocilizumab. All these were girls <6 years with neutrophil to lymphocyte ratio (NLR) >3.5, had dilated cardiac chambers with significantly decreased ventricular ejection fractions and dilated coronary arteries. Mean length of hospital stay was around 10 days. In Group 1, gastrointestinal and cardiovascular symptoms were prominent. While in group 2, prominent symptoms were gastrointestinal and mucocutaneous. Conclusion: Most of the children in this study had coronary artery abnormalities, low incidence of RT-PCR positivity and presence of SARS–CoV-2 antibodies. Use of tocilizumab to control the inflammatory response is likely to be beneficial in steroid resistant cases. Coronaries and cardiac function reverts to normal in a month without any residual effects. |
| first_indexed | 2024-03-08T13:13:29Z |
| format | Article |
| id | doaj.art-a6b549ef1fd444a1ad3a9116bc12909c |
| institution | Directory Open Access Journal |
| issn | 2666-1802 2666-1810 |
| language | English |
| last_indexed | 2024-03-08T13:13:29Z |
| publishDate | 2024-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | APIK Journal of Internal Medicine |
| spelling | doaj.art-a6b549ef1fd444a1ad3a9116bc12909c2024-01-18T10:34:18ZengWolters Kluwer Medknow PublicationsAPIK Journal of Internal Medicine2666-18022666-18102024-01-01121465010.4103/ajim.ajim_93_22Clinical Profile, Outcome, and Short-Term Follow-up of Pediatric Multisystem Inflammatory Syndrome Cases in a Tertiary Care Center of Western IndiaQury NagadiaGhosha Nilesh PandavNidhi DhamechaSuhani PatelAnurag GuptaNehal PatelBackground: There are several reports of the pediatric multisystem inflammatory syndrome associated with COVID-19 in children globally. The current Indian data on PIMS-TS associated with COVID-19 are scarce. Aims and Objectives: To describe demographic, clinical and laboratory findings, management, and follow - up of cases of PIMS-TS. Materials and Method: We analyzed children presenting to our hospital from July 2020 to January 2021, with PIMS-TS. Cases were categorized into two subsets: Group 1 (MIS-C with shock) and Group 2 (MIS-C without shock). Coronary Z scores of >2.5 were considered as dilated. We followed all the patients at 15 days, 3 months, 6 months, and 12 months. Results: Total 11 patients with diagnosis of MIS-C were treated during this study period. Mean age of presentation was 6.5 years. All patients in Group 1 needed inotropic support and treated with steroids and intravenous immunoglobulin. Three patients required administration of tocilizumab. All these were girls <6 years with neutrophil to lymphocyte ratio (NLR) >3.5, had dilated cardiac chambers with significantly decreased ventricular ejection fractions and dilated coronary arteries. Mean length of hospital stay was around 10 days. In Group 1, gastrointestinal and cardiovascular symptoms were prominent. While in group 2, prominent symptoms were gastrointestinal and mucocutaneous. Conclusion: Most of the children in this study had coronary artery abnormalities, low incidence of RT-PCR positivity and presence of SARS–CoV-2 antibodies. Use of tocilizumab to control the inflammatory response is likely to be beneficial in steroid resistant cases. Coronaries and cardiac function reverts to normal in a month without any residual effects.http://www.ajim.in/article.asp?issn=2666-1802;year=2024;volume=12;issue=1;spage=46;epage=50;aulast=Nagadiacovid-19kawasakimultisystem inflammatory syndrome in childrenpediatric multisystem inflammatory syndromepediatric multisystem inflammatory syndrome-ts |
| spellingShingle | Qury Nagadia Ghosha Nilesh Pandav Nidhi Dhamecha Suhani Patel Anurag Gupta Nehal Patel Clinical Profile, Outcome, and Short-Term Follow-up of Pediatric Multisystem Inflammatory Syndrome Cases in a Tertiary Care Center of Western India APIK Journal of Internal Medicine covid-19 kawasaki multisystem inflammatory syndrome in children pediatric multisystem inflammatory syndrome pediatric multisystem inflammatory syndrome-ts |
| title | Clinical Profile, Outcome, and Short-Term Follow-up of Pediatric Multisystem Inflammatory Syndrome Cases in a Tertiary Care Center of Western India |
| title_full | Clinical Profile, Outcome, and Short-Term Follow-up of Pediatric Multisystem Inflammatory Syndrome Cases in a Tertiary Care Center of Western India |
| title_fullStr | Clinical Profile, Outcome, and Short-Term Follow-up of Pediatric Multisystem Inflammatory Syndrome Cases in a Tertiary Care Center of Western India |
| title_full_unstemmed | Clinical Profile, Outcome, and Short-Term Follow-up of Pediatric Multisystem Inflammatory Syndrome Cases in a Tertiary Care Center of Western India |
| title_short | Clinical Profile, Outcome, and Short-Term Follow-up of Pediatric Multisystem Inflammatory Syndrome Cases in a Tertiary Care Center of Western India |
| title_sort | clinical profile outcome and short term follow up of pediatric multisystem inflammatory syndrome cases in a tertiary care center of western india |
| topic | covid-19 kawasaki multisystem inflammatory syndrome in children pediatric multisystem inflammatory syndrome pediatric multisystem inflammatory syndrome-ts |
| url | http://www.ajim.in/article.asp?issn=2666-1802;year=2024;volume=12;issue=1;spage=46;epage=50;aulast=Nagadia |
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