Protection of Fatty Liver by the Intake of Fermented Soybean Paste, <i>Miso</i>, and Its Pre-Fermented Mixture
Soybeans and fermented soy-derived foodstuffs contain many functional components and demonstrate various beneficial effects. In this report, we demonstrate the anti-fatty liver effect of <i>miso,</i> a traditional fermented product made from soybeans and rice molded in <i>Aspergill...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/10/2/291 |
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| author | Ryoko Kanno Tetsuo Koshizuka Nozomu Miyazaki Takahiro Kobayashi Ken Ishioka Chiaki Ozaki Hideki Chiba Tatsuo Suzutani |
| author_facet | Ryoko Kanno Tetsuo Koshizuka Nozomu Miyazaki Takahiro Kobayashi Ken Ishioka Chiaki Ozaki Hideki Chiba Tatsuo Suzutani |
| author_sort | Ryoko Kanno |
| collection | DOAJ |
| description | Soybeans and fermented soy-derived foodstuffs contain many functional components and demonstrate various beneficial effects. In this report, we demonstrate the anti-fatty liver effect of <i>miso,</i> a traditional fermented product made from soybeans and rice molded in <i>Aspergillus oryzae</i> and forming a common part of the Japanese diet. After acclimation for 2 weeks, male and female C57BL/6J mice were fed with a normal diet (ND), a high-fat diet (HFD), a HFD containing 5% <i>miso</i> (HFD+M), or a HFD containing 5% pre-fermented <i>miso</i> (HFD+PFM) for 20 weeks. Although mice in the HFD group developed typical fatty liver, the consumption of <i>miso</i> or PFM significantly ameliorated the progression of fatty liver in female mice. The liver weight and the average nonalcoholic fatty liver disease activity score (NAS) were significantly reduced in the HFD+M and HFD+PFM groups. In addition, leptin and resistin levels in the serum were decreased in the HFD+M and HFD+PFM groups. The progression of fatty liver was also prevented by the consumption of <i>miso</i> or PFM in male mice, although there were no decreases in NAS. Therefore, <i>miso</i> appears to be a potential food to prevent lifestyle-related diseases such as metabolic syndrome. |
| first_indexed | 2024-03-09T06:13:55Z |
| format | Article |
| id | doaj.art-a6b5e6cee84a4d3297660f7e8428f172 |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-09T06:13:55Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-a6b5e6cee84a4d3297660f7e8428f1722023-12-03T11:55:15ZengMDPI AGFoods2304-81582021-02-0110229110.3390/foods10020291Protection of Fatty Liver by the Intake of Fermented Soybean Paste, <i>Miso</i>, and Its Pre-Fermented MixtureRyoko Kanno0Tetsuo Koshizuka1Nozomu Miyazaki2Takahiro Kobayashi3Ken Ishioka4Chiaki Ozaki5Hideki Chiba6Tatsuo Suzutani7Department of Microbiology, Fukushima Medical University School of Medicine, Fukushima 960-1295, JapanDepartment of Microbiology, Fukushima Medical University School of Medicine, Fukushima 960-1295, JapanDepartment of Microbiology, Fukushima Medical University School of Medicine, Fukushima 960-1295, JapanDepartment of Microbiology, Fukushima Medical University School of Medicine, Fukushima 960-1295, JapanDepartment of Microbiology, Fukushima Medical University School of Medicine, Fukushima 960-1295, JapanDepartment of Microbiology, Fukushima Medical University School of Medicine, Fukushima 960-1295, JapanDepartment of Basic Pathology, Fukushima Medical University School of Medicine, Fukushima 960-1295, JapanDepartment of Microbiology, Fukushima Medical University School of Medicine, Fukushima 960-1295, JapanSoybeans and fermented soy-derived foodstuffs contain many functional components and demonstrate various beneficial effects. In this report, we demonstrate the anti-fatty liver effect of <i>miso,</i> a traditional fermented product made from soybeans and rice molded in <i>Aspergillus oryzae</i> and forming a common part of the Japanese diet. After acclimation for 2 weeks, male and female C57BL/6J mice were fed with a normal diet (ND), a high-fat diet (HFD), a HFD containing 5% <i>miso</i> (HFD+M), or a HFD containing 5% pre-fermented <i>miso</i> (HFD+PFM) for 20 weeks. Although mice in the HFD group developed typical fatty liver, the consumption of <i>miso</i> or PFM significantly ameliorated the progression of fatty liver in female mice. The liver weight and the average nonalcoholic fatty liver disease activity score (NAS) were significantly reduced in the HFD+M and HFD+PFM groups. In addition, leptin and resistin levels in the serum were decreased in the HFD+M and HFD+PFM groups. The progression of fatty liver was also prevented by the consumption of <i>miso</i> or PFM in male mice, although there were no decreases in NAS. Therefore, <i>miso</i> appears to be a potential food to prevent lifestyle-related diseases such as metabolic syndrome.https://www.mdpi.com/2304-8158/10/2/291<i>miso</i>soy-derived foodstuffsnonalcoholic fatty liver diseaseisoflavoneleptinresistin |
| spellingShingle | Ryoko Kanno Tetsuo Koshizuka Nozomu Miyazaki Takahiro Kobayashi Ken Ishioka Chiaki Ozaki Hideki Chiba Tatsuo Suzutani Protection of Fatty Liver by the Intake of Fermented Soybean Paste, <i>Miso</i>, and Its Pre-Fermented Mixture Foods <i>miso</i> soy-derived foodstuffs nonalcoholic fatty liver disease isoflavone leptin resistin |
| title | Protection of Fatty Liver by the Intake of Fermented Soybean Paste, <i>Miso</i>, and Its Pre-Fermented Mixture |
| title_full | Protection of Fatty Liver by the Intake of Fermented Soybean Paste, <i>Miso</i>, and Its Pre-Fermented Mixture |
| title_fullStr | Protection of Fatty Liver by the Intake of Fermented Soybean Paste, <i>Miso</i>, and Its Pre-Fermented Mixture |
| title_full_unstemmed | Protection of Fatty Liver by the Intake of Fermented Soybean Paste, <i>Miso</i>, and Its Pre-Fermented Mixture |
| title_short | Protection of Fatty Liver by the Intake of Fermented Soybean Paste, <i>Miso</i>, and Its Pre-Fermented Mixture |
| title_sort | protection of fatty liver by the intake of fermented soybean paste i miso i and its pre fermented mixture |
| topic | <i>miso</i> soy-derived foodstuffs nonalcoholic fatty liver disease isoflavone leptin resistin |
| url | https://www.mdpi.com/2304-8158/10/2/291 |
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