Assessment of serum macrophage migration inhibitory factor (MIF), adiponectin, and other adipokines as potential markers of proteinuria and renal dysfunction in lupus nephritis: a cross-sectional study
Abstract Background To date, the association of serum macrophage migration inhibitory factor (MIF) and serum adipokines with lupus nephritis is controversial. Objective To assess the utility of serum MIF, leptin, adiponectin and resistin levels as markers of proteinuria and renal dysfunction in lupu...
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| Format: | Article |
| Language: | English |
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BMC
2020-10-01
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| Series: | Biomarker Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40364-020-00236-x |
| _version_ | 1819026405380325376 |
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| author | Jorge Ivan Gamez-Nava Valeria Diaz-Rizo Edsaul Emilio Perez-Guerrero Jose Francisco Muñoz-Valle Ana Miriam Saldaña-Cruz Nicte Selene Fajardo-Robledo Heriberto Jacobo-Cuevas Cesar Arturo Nava-Valdivia Miriam Fabiola Alcaraz-Lopez Xochitl Trujillo Miguel Huerta Ernesto German Cardona-Muñoz Laura Gonzalez-Lopez |
| author_facet | Jorge Ivan Gamez-Nava Valeria Diaz-Rizo Edsaul Emilio Perez-Guerrero Jose Francisco Muñoz-Valle Ana Miriam Saldaña-Cruz Nicte Selene Fajardo-Robledo Heriberto Jacobo-Cuevas Cesar Arturo Nava-Valdivia Miriam Fabiola Alcaraz-Lopez Xochitl Trujillo Miguel Huerta Ernesto German Cardona-Muñoz Laura Gonzalez-Lopez |
| author_sort | Jorge Ivan Gamez-Nava |
| collection | DOAJ |
| description | Abstract Background To date, the association of serum macrophage migration inhibitory factor (MIF) and serum adipokines with lupus nephritis is controversial. Objective To assess the utility of serum MIF, leptin, adiponectin and resistin levels as markers of proteinuria and renal dysfunction in lupus nephritis. Methods Cross-sectional study including 196 systemic lupus erythematosus (SLE) patients and 52 healthy controls (HCs). Disease activity was assessed by Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). Renal SLE involvement was investigated by renal-SLEDAI. MIF, adiponectin, leptin and resistin levels were quantified by ELISA. We assessed the correlations of quantitative variables by Spearman correlation (rs). Multivariable linear regression adjusted the variables associated with the severity of proteinuria. Results SLE patients had higher MIF (p = 0.02) and adiponectin (p < 0.001) than HCs. Patients with renal SLE involvement (n = 43) had higher adiponectin (19.0 vs 13.3 μg/mL, p = 0.002) and resistin (10.7 vs 8.9 ng/mL, p = 0.01) than patients with non-renal SLE (n = 153). Proteinuria correlated with high adiponectin (r s = 0.19, p < 0.009) and resistin (r s = 0.26, p < 0.001). MIF (r s = 0.27, p = 0.04). Resistin correlated with increased creatinine (r s = 0.18, p = 0.02). High renal-SLEDAI correlated with adiponectin (r s = 0.21, p = 0.004). Multiple linear regression showed that elevated adiponectin (p = 0.02), younger age (p = 0.04) and low MIF (p = 0.02) were associated with the severity of proteinuria. Low MIF and high adiponectin levels interacted to explain the association with the severity of proteinuria (R2 = 0.41). Conclusions High adiponectin combined with low MIF concentrations int+eract to explain the severity of proteinuria in renal SLE. These findings highlight the relevance of adiponectin, resistin and MIF as markers of LN. |
| first_indexed | 2024-12-21T05:26:03Z |
| format | Article |
| id | doaj.art-a6b60ff2db3f494895270182614cdf7c |
| institution | Directory Open Access Journal |
| issn | 2050-7771 |
| language | English |
| last_indexed | 2024-12-21T05:26:03Z |
| publishDate | 2020-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Biomarker Research |
| spelling | doaj.art-a6b60ff2db3f494895270182614cdf7c2022-12-21T19:14:41ZengBMCBiomarker Research2050-77712020-10-018111210.1186/s40364-020-00236-xAssessment of serum macrophage migration inhibitory factor (MIF), adiponectin, and other adipokines as potential markers of proteinuria and renal dysfunction in lupus nephritis: a cross-sectional studyJorge Ivan Gamez-Nava0Valeria Diaz-Rizo1Edsaul Emilio Perez-Guerrero2Jose Francisco Muñoz-Valle3Ana Miriam Saldaña-Cruz4Nicte Selene Fajardo-Robledo5Heriberto Jacobo-Cuevas6Cesar Arturo Nava-Valdivia7Miriam Fabiola Alcaraz-Lopez8Xochitl Trujillo9Miguel Huerta10Ernesto German Cardona-Muñoz11Laura Gonzalez-Lopez12Programa de Doctorado en Farmacología del Departamento de Fisiología y Programa de Doctorado en Salud del Pública Depatamento de Salud Pública, Universidad de Guadalajara, Centro Universitario de Ciencias de la SaludDepartamento de Disciplinas Filosófico, Metodológico e Instrumentales, Universidad de Guadalajara, Centro Universitario de Ciencias de la SaludUniversidad de Guadalajara, Centro Universitario de Ciencias de la Salud, Instituto de Investigación en Ciencias BiomédicasUniversidad de Guadalajara, Centro Universitario de Ciencias de la Salud, Instituto de Investigación en Ciencias BiomédicasDepartamento de Fisiología, Universidad de Guadalajara, Centro Universitario de Ciencias de la SaludLaboratorio de Investigación y Desarrollo Farmacéutico, Universidad de Guadalajara, Centro Universitario de Ciencias Exactas e IngenieríasPrograma de Doctorado en Farmacología del Departamento de Fisiología y Programa de Doctorado en Salud del Pública Depatamento de Salud Pública, Universidad de Guadalajara, Centro Universitario de Ciencias de la SaludDepartamento de Microbiología y Patología, Universidad de Guadalajara, Centro Universitario de Ciencias de la SaludInstituto Mexicano del Seguro Social, HGR45Universidad de Colima, Centro Universitario de Investigaciones BiomédicasUniversidad de Colima, Centro Universitario de Investigaciones BiomédicasDepartamento de Fisiología, Universidad de Guadalajara, Centro Universitario de Ciencias de la SaludPrograma de Doctorado en Farmacología del Departamento de Fisiología y Programa de Doctorado en Salud del Pública Depatamento de Salud Pública, Universidad de Guadalajara, Centro Universitario de Ciencias de la SaludAbstract Background To date, the association of serum macrophage migration inhibitory factor (MIF) and serum adipokines with lupus nephritis is controversial. Objective To assess the utility of serum MIF, leptin, adiponectin and resistin levels as markers of proteinuria and renal dysfunction in lupus nephritis. Methods Cross-sectional study including 196 systemic lupus erythematosus (SLE) patients and 52 healthy controls (HCs). Disease activity was assessed by Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). Renal SLE involvement was investigated by renal-SLEDAI. MIF, adiponectin, leptin and resistin levels were quantified by ELISA. We assessed the correlations of quantitative variables by Spearman correlation (rs). Multivariable linear regression adjusted the variables associated with the severity of proteinuria. Results SLE patients had higher MIF (p = 0.02) and adiponectin (p < 0.001) than HCs. Patients with renal SLE involvement (n = 43) had higher adiponectin (19.0 vs 13.3 μg/mL, p = 0.002) and resistin (10.7 vs 8.9 ng/mL, p = 0.01) than patients with non-renal SLE (n = 153). Proteinuria correlated with high adiponectin (r s = 0.19, p < 0.009) and resistin (r s = 0.26, p < 0.001). MIF (r s = 0.27, p = 0.04). Resistin correlated with increased creatinine (r s = 0.18, p = 0.02). High renal-SLEDAI correlated with adiponectin (r s = 0.21, p = 0.004). Multiple linear regression showed that elevated adiponectin (p = 0.02), younger age (p = 0.04) and low MIF (p = 0.02) were associated with the severity of proteinuria. Low MIF and high adiponectin levels interacted to explain the association with the severity of proteinuria (R2 = 0.41). Conclusions High adiponectin combined with low MIF concentrations int+eract to explain the severity of proteinuria in renal SLE. These findings highlight the relevance of adiponectin, resistin and MIF as markers of LN.http://link.springer.com/article/10.1186/s40364-020-00236-xLupus nephritisLupus Erythematosus systemicMIFAdiponectinAdipokinesBiomarkers |
| spellingShingle | Jorge Ivan Gamez-Nava Valeria Diaz-Rizo Edsaul Emilio Perez-Guerrero Jose Francisco Muñoz-Valle Ana Miriam Saldaña-Cruz Nicte Selene Fajardo-Robledo Heriberto Jacobo-Cuevas Cesar Arturo Nava-Valdivia Miriam Fabiola Alcaraz-Lopez Xochitl Trujillo Miguel Huerta Ernesto German Cardona-Muñoz Laura Gonzalez-Lopez Assessment of serum macrophage migration inhibitory factor (MIF), adiponectin, and other adipokines as potential markers of proteinuria and renal dysfunction in lupus nephritis: a cross-sectional study Biomarker Research Lupus nephritis Lupus Erythematosus systemic MIF Adiponectin Adipokines Biomarkers |
| title | Assessment of serum macrophage migration inhibitory factor (MIF), adiponectin, and other adipokines as potential markers of proteinuria and renal dysfunction in lupus nephritis: a cross-sectional study |
| title_full | Assessment of serum macrophage migration inhibitory factor (MIF), adiponectin, and other adipokines as potential markers of proteinuria and renal dysfunction in lupus nephritis: a cross-sectional study |
| title_fullStr | Assessment of serum macrophage migration inhibitory factor (MIF), adiponectin, and other adipokines as potential markers of proteinuria and renal dysfunction in lupus nephritis: a cross-sectional study |
| title_full_unstemmed | Assessment of serum macrophage migration inhibitory factor (MIF), adiponectin, and other adipokines as potential markers of proteinuria and renal dysfunction in lupus nephritis: a cross-sectional study |
| title_short | Assessment of serum macrophage migration inhibitory factor (MIF), adiponectin, and other adipokines as potential markers of proteinuria and renal dysfunction in lupus nephritis: a cross-sectional study |
| title_sort | assessment of serum macrophage migration inhibitory factor mif adiponectin and other adipokines as potential markers of proteinuria and renal dysfunction in lupus nephritis a cross sectional study |
| topic | Lupus nephritis Lupus Erythematosus systemic MIF Adiponectin Adipokines Biomarkers |
| url | http://link.springer.com/article/10.1186/s40364-020-00236-x |
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