Effects of ultrasound-guided lumbar-sciatic nerve block and epidural anesthesia on the levels of IL-6, IL-8, TNF-a and coagulation factors in peripheral blood of elderly patients after hip arthroplasty
Background: To investigate the effects of ultrasound-guided lumbar-sciatic nerve block and epidural anesthesia on the levels of inflammatory factors such as Interleukin-6 (IL6), Interleukin-8 (IL-8), Tumor necrosis factor-a (TNF-a) and coagulation factors in peripheral blood of elderly patients afte...
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Society of Medical Biochemists of Serbia, Belgrade
2022-01-01
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Series: | Journal of Medical Biochemistry |
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Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2022/1452-82582204433H.pdf |
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author | Huang Zhi Cai Yan Yang Yunfei Shi Jin Zhao Xuya Mo Haise Zeng Qingfan |
author_facet | Huang Zhi Cai Yan Yang Yunfei Shi Jin Zhao Xuya Mo Haise Zeng Qingfan |
author_sort | Huang Zhi |
collection | DOAJ |
description | Background: To investigate the effects of ultrasound-guided lumbar-sciatic nerve block and epidural anesthesia on the levels of inflammatory factors such as Interleukin-6 (IL6), Interleukin-8 (IL-8), Tumor necrosis factor-a (TNF-a) and coagulation factors in peripheral blood of elderly patients after hip arthroplasty to provides reference value for the choice of intraoperative anesthesia. Methods: 96 elderly patients underwent hip arthroplasty in our hospital from March 2018 to December 2019 were selected and divided into ultrasound-guided lumbar-sciatic nerve block group (group A) and epidural anesthesia group (group B) randomly , there were 48 cases in each group. The onset time of intraoperative anesthesia, postoperative hemodynamic indexes, pain score, inflammatory factors and blood coagulation factor levels were compared between group A and group B. Results: It was proved that: (1) The onset time of sensory block and motor block in group B were shorter compared with group A, and the maintenance time of anesthesia was prolonged (P<0.05); (2) Compared with group A, visual analogue scale (VAS) score of group B patients after operation was lower (P<0.05); (3) The systolic blood pressure (SBP) and diastolic blood pressure (DBP) of group B were higher than group A (P<0.05) ) at T1 and T2, while the comparison of SBP and DBP between groups was not statistical difference at T3 and T4 (P>0.05); (3) Compared with group A, the levels of TNF- , IL-8and IL-6 in peripheral blood of group B decreased after T2, T3 and T4 (P<0.05); (4) Statistical difference in plasma factor V activity (FV:C), coagulation factor VIII activity (FVIII:C) and fibrinogen (FIB) levels were showed between groups A and B at T2, T3 and T4 (P<0.05) with significantly lower values in group B compared to group A(P<0.05). (5) The half-year mortality rates of patients in two group were 5.56% and 8.33% respectively. There was no significant difference between group A and group B (P>0.05). Conclusions: Compared with epidural anesthesia, lumbarsciatic nerve block is showed significantly lower values in concentration of peripheral blood coagulation factors and inflammatory factors after surgery, thereby alleviating postoperative hypercoagulability and inflammation. |
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spelling | doaj.art-a6b749560f354e268f286ad221a489132022-12-22T03:55:40ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662022-01-0141443344010.5937/jomb0-358471452-82582204433HEffects of ultrasound-guided lumbar-sciatic nerve block and epidural anesthesia on the levels of IL-6, IL-8, TNF-a and coagulation factors in peripheral blood of elderly patients after hip arthroplastyHuang Zhi0Cai Yan1Yang Yunfei2Shi Jin3Zhao Xuya4Mo Haise5Zeng Qingfan6The Affiliated Hospital of Guizhou Medical University, Department of Interventional Radiology, Guiyang, People Republic ChinaThe Affiliated Hospital of Guizhou Medical University, Ultrasonic Center, Guiyang, People Republic ChinaGuizhou Medical University, Institute of Image, Guiyang, People Republic ChinaThe Affiliated Hospital of Guizhou Medical University, Guiyang, Department of Anesthesiology, Guizhou, People Republic ChinaGuizhou Medical University, Institute of Image, Guiyang, People Republic ChinaGuizhou Medical University, Institute of Image, Guiyang, People Republic ChinaThe Affiliated Baiyun Hospital of Guizhou Medical University, Guiyang, Department of Anesthesiology, Guizhou, People Republic ChinaBackground: To investigate the effects of ultrasound-guided lumbar-sciatic nerve block and epidural anesthesia on the levels of inflammatory factors such as Interleukin-6 (IL6), Interleukin-8 (IL-8), Tumor necrosis factor-a (TNF-a) and coagulation factors in peripheral blood of elderly patients after hip arthroplasty to provides reference value for the choice of intraoperative anesthesia. Methods: 96 elderly patients underwent hip arthroplasty in our hospital from March 2018 to December 2019 were selected and divided into ultrasound-guided lumbar-sciatic nerve block group (group A) and epidural anesthesia group (group B) randomly , there were 48 cases in each group. The onset time of intraoperative anesthesia, postoperative hemodynamic indexes, pain score, inflammatory factors and blood coagulation factor levels were compared between group A and group B. Results: It was proved that: (1) The onset time of sensory block and motor block in group B were shorter compared with group A, and the maintenance time of anesthesia was prolonged (P<0.05); (2) Compared with group A, visual analogue scale (VAS) score of group B patients after operation was lower (P<0.05); (3) The systolic blood pressure (SBP) and diastolic blood pressure (DBP) of group B were higher than group A (P<0.05) ) at T1 and T2, while the comparison of SBP and DBP between groups was not statistical difference at T3 and T4 (P>0.05); (3) Compared with group A, the levels of TNF- , IL-8and IL-6 in peripheral blood of group B decreased after T2, T3 and T4 (P<0.05); (4) Statistical difference in plasma factor V activity (FV:C), coagulation factor VIII activity (FVIII:C) and fibrinogen (FIB) levels were showed between groups A and B at T2, T3 and T4 (P<0.05) with significantly lower values in group B compared to group A(P<0.05). (5) The half-year mortality rates of patients in two group were 5.56% and 8.33% respectively. There was no significant difference between group A and group B (P>0.05). Conclusions: Compared with epidural anesthesia, lumbarsciatic nerve block is showed significantly lower values in concentration of peripheral blood coagulation factors and inflammatory factors after surgery, thereby alleviating postoperative hypercoagulability and inflammation.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2022/1452-82582204433H.pdflumbar slave-sciatic nerve blockepidural anesthesiainflammatory factorcoagulation factor |
spellingShingle | Huang Zhi Cai Yan Yang Yunfei Shi Jin Zhao Xuya Mo Haise Zeng Qingfan Effects of ultrasound-guided lumbar-sciatic nerve block and epidural anesthesia on the levels of IL-6, IL-8, TNF-a and coagulation factors in peripheral blood of elderly patients after hip arthroplasty Journal of Medical Biochemistry lumbar slave-sciatic nerve block epidural anesthesia inflammatory factor coagulation factor |
title | Effects of ultrasound-guided lumbar-sciatic nerve block and epidural anesthesia on the levels of IL-6, IL-8, TNF-a and coagulation factors in peripheral blood of elderly patients after hip arthroplasty |
title_full | Effects of ultrasound-guided lumbar-sciatic nerve block and epidural anesthesia on the levels of IL-6, IL-8, TNF-a and coagulation factors in peripheral blood of elderly patients after hip arthroplasty |
title_fullStr | Effects of ultrasound-guided lumbar-sciatic nerve block and epidural anesthesia on the levels of IL-6, IL-8, TNF-a and coagulation factors in peripheral blood of elderly patients after hip arthroplasty |
title_full_unstemmed | Effects of ultrasound-guided lumbar-sciatic nerve block and epidural anesthesia on the levels of IL-6, IL-8, TNF-a and coagulation factors in peripheral blood of elderly patients after hip arthroplasty |
title_short | Effects of ultrasound-guided lumbar-sciatic nerve block and epidural anesthesia on the levels of IL-6, IL-8, TNF-a and coagulation factors in peripheral blood of elderly patients after hip arthroplasty |
title_sort | effects of ultrasound guided lumbar sciatic nerve block and epidural anesthesia on the levels of il 6 il 8 tnf a and coagulation factors in peripheral blood of elderly patients after hip arthroplasty |
topic | lumbar slave-sciatic nerve block epidural anesthesia inflammatory factor coagulation factor |
url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2022/1452-82582204433H.pdf |
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