Endoscopic features and clinical outcomes of cytomegalovirus gastroenterocolitis in immunocompetent patients
Abstract We aimed to investigate the endoscopic features and clinical course of CMV gastroenterocolitis in immunocompetent patients. We reviewed the medical records and endoscopic images of 86 immunocompetent patients with CMV gastroenterocolitis. Immunocompetent patients were defined as those witho...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-85845-8 |
| _version_ | 1818400544860930048 |
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| author | Jiyoung Yoon Junghwan Lee Dae Sung Kim Jin Wook Lee Seung Wook Hong Ha Won Hwang Sung Wook Hwang Sang Hyoung Park Dong-Hoon Yang Byong Duk Ye Seung-Jae Myung Hwoon-Yong Jung Suk-Kyun Yang Jeong-Sik Byeon |
| author_facet | Jiyoung Yoon Junghwan Lee Dae Sung Kim Jin Wook Lee Seung Wook Hong Ha Won Hwang Sung Wook Hwang Sang Hyoung Park Dong-Hoon Yang Byong Duk Ye Seung-Jae Myung Hwoon-Yong Jung Suk-Kyun Yang Jeong-Sik Byeon |
| author_sort | Jiyoung Yoon |
| collection | DOAJ |
| description | Abstract We aimed to investigate the endoscopic features and clinical course of CMV gastroenterocolitis in immunocompetent patients. We reviewed the medical records and endoscopic images of 86 immunocompetent patients with CMV gastroenterocolitis. Immunocompetent patients were defined as those without congenital or acquired immunodeficiency syndrome, use of anti-cancer chemotherapeutic and immunosuppressive agents, and inflammatory bowel diseases. The mean age was 65.5 ± 11.8 years and 53 (61.6%) were male. Sixty-eight (79.1%) patients had comorbidities. Upper gastrointestinal-dominant, small bowel-dominant, and colon-dominant types were observed in 19, 7, and 60 patients, respectively. Endoscopic features could be classified into discrete ulcerative type with/without exudate and diffuse erythematous type with/without exudate. Antiviral treatment with ganciclovir was initiated in 51 patients (59.3%), 40 of whom improved and 1 improved after changing ganciclovir to foscarnet. Thirty-three patients (38.4%) improved without antiviral treatment. Surgery was necessary in two patients because of colon perforation before antiviral treatment. Another two patients underwent surgery because of sigmoid stricture and cecal perforation during antiviral treatment. Endoscopic type was not associated with clinical outcomes, such as surgery and death. CMV gastroenterocolitis in immunocompetent patients mostly occur in older patients with comorbidities, and the endoscopic features vary with no association with clinical outcomes. |
| first_indexed | 2024-12-14T07:38:14Z |
| format | Article |
| id | doaj.art-a6b74fb2b0124aa8a5d8c01b57760571 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-14T07:38:14Z |
| publishDate | 2021-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-a6b74fb2b0124aa8a5d8c01b577605712022-12-21T23:11:07ZengNature PortfolioScientific Reports2045-23222021-03-0111111010.1038/s41598-021-85845-8Endoscopic features and clinical outcomes of cytomegalovirus gastroenterocolitis in immunocompetent patientsJiyoung Yoon0Junghwan Lee1Dae Sung Kim2Jin Wook Lee3Seung Wook Hong4Ha Won Hwang5Sung Wook Hwang6Sang Hyoung Park7Dong-Hoon Yang8Byong Duk Ye9Seung-Jae Myung10Hwoon-Yong Jung11Suk-Kyun Yang12Jeong-Sik Byeon13Department of Gastroenterology, Asan Medical Center, University of Ulsan College of MedicineDepartment of Gastroenterology, Asan Medical Center, University of Ulsan College of MedicineDepartment of Gastroenterology, Asan Medical Center, University of Ulsan College of MedicineDepartment of Gastroenterology, Asan Medical Center, University of Ulsan College of MedicineDepartment of Gastroenterology, Asan Medical Center, University of Ulsan College of MedicineDepartment of Gastroenterology, Asan Medical Center, University of Ulsan College of MedicineDepartment of Gastroenterology, Asan Medical Center, University of Ulsan College of MedicineDepartment of Gastroenterology, Asan Medical Center, University of Ulsan College of MedicineDepartment of Gastroenterology, Asan Medical Center, University of Ulsan College of MedicineDepartment of Gastroenterology, Asan Medical Center, University of Ulsan College of MedicineDepartment of Gastroenterology, Asan Medical Center, University of Ulsan College of MedicineDepartment of Gastroenterology, Asan Medical Center, University of Ulsan College of MedicineDepartment of Gastroenterology, Asan Medical Center, University of Ulsan College of MedicineDepartment of Gastroenterology, Asan Medical Center, University of Ulsan College of MedicineAbstract We aimed to investigate the endoscopic features and clinical course of CMV gastroenterocolitis in immunocompetent patients. We reviewed the medical records and endoscopic images of 86 immunocompetent patients with CMV gastroenterocolitis. Immunocompetent patients were defined as those without congenital or acquired immunodeficiency syndrome, use of anti-cancer chemotherapeutic and immunosuppressive agents, and inflammatory bowel diseases. The mean age was 65.5 ± 11.8 years and 53 (61.6%) were male. Sixty-eight (79.1%) patients had comorbidities. Upper gastrointestinal-dominant, small bowel-dominant, and colon-dominant types were observed in 19, 7, and 60 patients, respectively. Endoscopic features could be classified into discrete ulcerative type with/without exudate and diffuse erythematous type with/without exudate. Antiviral treatment with ganciclovir was initiated in 51 patients (59.3%), 40 of whom improved and 1 improved after changing ganciclovir to foscarnet. Thirty-three patients (38.4%) improved without antiviral treatment. Surgery was necessary in two patients because of colon perforation before antiviral treatment. Another two patients underwent surgery because of sigmoid stricture and cecal perforation during antiviral treatment. Endoscopic type was not associated with clinical outcomes, such as surgery and death. CMV gastroenterocolitis in immunocompetent patients mostly occur in older patients with comorbidities, and the endoscopic features vary with no association with clinical outcomes.https://doi.org/10.1038/s41598-021-85845-8 |
| spellingShingle | Jiyoung Yoon Junghwan Lee Dae Sung Kim Jin Wook Lee Seung Wook Hong Ha Won Hwang Sung Wook Hwang Sang Hyoung Park Dong-Hoon Yang Byong Duk Ye Seung-Jae Myung Hwoon-Yong Jung Suk-Kyun Yang Jeong-Sik Byeon Endoscopic features and clinical outcomes of cytomegalovirus gastroenterocolitis in immunocompetent patients Scientific Reports |
| title | Endoscopic features and clinical outcomes of cytomegalovirus gastroenterocolitis in immunocompetent patients |
| title_full | Endoscopic features and clinical outcomes of cytomegalovirus gastroenterocolitis in immunocompetent patients |
| title_fullStr | Endoscopic features and clinical outcomes of cytomegalovirus gastroenterocolitis in immunocompetent patients |
| title_full_unstemmed | Endoscopic features and clinical outcomes of cytomegalovirus gastroenterocolitis in immunocompetent patients |
| title_short | Endoscopic features and clinical outcomes of cytomegalovirus gastroenterocolitis in immunocompetent patients |
| title_sort | endoscopic features and clinical outcomes of cytomegalovirus gastroenterocolitis in immunocompetent patients |
| url | https://doi.org/10.1038/s41598-021-85845-8 |
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