Mu-Opioid Receptor 1 and C-Reactive Protein Single Nucleotide Polymorphisms as Biomarkers of Pain Intensity and Opioid Consumption
Children constitute a special group in pain therapy. Single nucleotide polymorphisms that are associated with differences in postoperative, inflammatory pain perception and opioid requirement are the A118G SNP in the mu-opioid receptor 1 (OPRM1) gene and the rs1205 CRP. This study aimed to determine...
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MDPI AG
2023-11-01
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| author | Aleksander Turczynowicz Piotr Jakubów Karolina Niedźwiecka Julia Kondracka Weronika Pużyńska Mariola Tałałaj Tomasz Guszczyn Paweł Grabala Oksana Kowalczuk Szymon Kocańda |
| author_facet | Aleksander Turczynowicz Piotr Jakubów Karolina Niedźwiecka Julia Kondracka Weronika Pużyńska Mariola Tałałaj Tomasz Guszczyn Paweł Grabala Oksana Kowalczuk Szymon Kocańda |
| author_sort | Aleksander Turczynowicz |
| collection | DOAJ |
| description | Children constitute a special group in pain therapy. Single nucleotide polymorphisms that are associated with differences in postoperative, inflammatory pain perception and opioid requirement are the A118G SNP in the mu-opioid receptor 1 (OPRM1) gene and the rs1205 CRP. This study aimed to determine connection between OPRM1 and rs1205 CRP SNPs in pediatric patients postoperatively and pain intensity, the opioid dose needed to control pain after scoliosis correction, and other clinical aspects. Genotypes of rs1205 CRP and OPRM1 polymorphisms in a sample of 31 patients were specified, and statistical analysis was performed in terms of age, genotype frequency, pain assessment, sufentanil flow, post-anesthesia care unit stay, and the use of coanalgesics. The frequency of A/A and A/G genotypes in the OPRM1 gene was in line with 1000Genomes data for the European population. Patients from the AG group of OPRM1 SNP more frequently required coanalgesics for adequate pain control; however, it was of weak statistical significance. Other parameters measured in the study were not statistically significant in relation to OPRM1 and CRP polymorphisms. The effect of SNPs on postoperative pain management and opioid therapy in children was not confirmed by this study. An expansion of the study sample and other opioid-related SNPs is required. |
| first_indexed | 2024-03-08T20:56:59Z |
| format | Article |
| id | doaj.art-a6b7f52e9577486e85613f067d461ec6 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-08T20:56:59Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-a6b7f52e9577486e85613f067d461ec62023-12-22T13:56:54ZengMDPI AGBrain Sciences2076-34252023-11-011312162910.3390/brainsci13121629Mu-Opioid Receptor 1 and C-Reactive Protein Single Nucleotide Polymorphisms as Biomarkers of Pain Intensity and Opioid ConsumptionAleksander Turczynowicz0Piotr Jakubów1Karolina Niedźwiecka2Julia Kondracka3Weronika Pużyńska4Mariola Tałałaj5Tomasz Guszczyn6Paweł Grabala7Oksana Kowalczuk8Szymon Kocańda9Department of Anesthesiology and Intensive Care for Children and Adolescents with Postoperative and Pain Treatment Unit, Medical University of Bialystok, 15-274 Bialystok, PolandDepartment of Anesthesiology and Intensive Care for Children and Adolescents with Postoperative and Pain Treatment Unit, Medical University of Bialystok, 15-274 Bialystok, PolandDepartment of Cardiosurgery, Medical University of Bialystok, 15-276 Bialystok, PolandDepartment of Anesthesiology and Intensive Care for Children and Adolescents with Postoperative and Pain Treatment Unit, Medical University of Bialystok, 15-274 Bialystok, PolandDepartment of Palliative Medicine, Medical University of Bialystok, 15-276 Bialystok, PolandDepartment of Anesthesiology and Intensive Care for Children and Adolescents with Postoperative and Pain Treatment Unit, Medical University of Bialystok, 15-274 Bialystok, PolandDepartment of Pediatric Orthopedics and Traumatology, Medical University of Bialystok, 15-274 Bialystok, PolandDepartment of Pediatric Orthopedics and Traumatology, Medical University of Bialystok, 15-274 Bialystok, PolandDepartment of Clinical Molecular Biology, Medical University of Bialystok, 15-269 Bialystok, PolandDepartment of Cardiosurgery, Medical University of Bialystok, 15-276 Bialystok, PolandChildren constitute a special group in pain therapy. Single nucleotide polymorphisms that are associated with differences in postoperative, inflammatory pain perception and opioid requirement are the A118G SNP in the mu-opioid receptor 1 (OPRM1) gene and the rs1205 CRP. This study aimed to determine connection between OPRM1 and rs1205 CRP SNPs in pediatric patients postoperatively and pain intensity, the opioid dose needed to control pain after scoliosis correction, and other clinical aspects. Genotypes of rs1205 CRP and OPRM1 polymorphisms in a sample of 31 patients were specified, and statistical analysis was performed in terms of age, genotype frequency, pain assessment, sufentanil flow, post-anesthesia care unit stay, and the use of coanalgesics. The frequency of A/A and A/G genotypes in the OPRM1 gene was in line with 1000Genomes data for the European population. Patients from the AG group of OPRM1 SNP more frequently required coanalgesics for adequate pain control; however, it was of weak statistical significance. Other parameters measured in the study were not statistically significant in relation to OPRM1 and CRP polymorphisms. The effect of SNPs on postoperative pain management and opioid therapy in children was not confirmed by this study. An expansion of the study sample and other opioid-related SNPs is required.https://www.mdpi.com/2076-3425/13/12/1629acute painpostoperative painoprm1SNPsingle nucleotide polymorphism |
| spellingShingle | Aleksander Turczynowicz Piotr Jakubów Karolina Niedźwiecka Julia Kondracka Weronika Pużyńska Mariola Tałałaj Tomasz Guszczyn Paweł Grabala Oksana Kowalczuk Szymon Kocańda Mu-Opioid Receptor 1 and C-Reactive Protein Single Nucleotide Polymorphisms as Biomarkers of Pain Intensity and Opioid Consumption Brain Sciences acute pain postoperative pain oprm1 SNP single nucleotide polymorphism |
| title | Mu-Opioid Receptor 1 and C-Reactive Protein Single Nucleotide Polymorphisms as Biomarkers of Pain Intensity and Opioid Consumption |
| title_full | Mu-Opioid Receptor 1 and C-Reactive Protein Single Nucleotide Polymorphisms as Biomarkers of Pain Intensity and Opioid Consumption |
| title_fullStr | Mu-Opioid Receptor 1 and C-Reactive Protein Single Nucleotide Polymorphisms as Biomarkers of Pain Intensity and Opioid Consumption |
| title_full_unstemmed | Mu-Opioid Receptor 1 and C-Reactive Protein Single Nucleotide Polymorphisms as Biomarkers of Pain Intensity and Opioid Consumption |
| title_short | Mu-Opioid Receptor 1 and C-Reactive Protein Single Nucleotide Polymorphisms as Biomarkers of Pain Intensity and Opioid Consumption |
| title_sort | mu opioid receptor 1 and c reactive protein single nucleotide polymorphisms as biomarkers of pain intensity and opioid consumption |
| topic | acute pain postoperative pain oprm1 SNP single nucleotide polymorphism |
| url | https://www.mdpi.com/2076-3425/13/12/1629 |
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