RELATIONSHIP BETWEEN T CELL IMMUNITY PARAMETERS AND SMOOTH-CELL CARCINOMA ANTIGEN (SCCA) CONTENTS IN BLOOD SERUM FROM THE PATIENTS WITH LOCAL DISSEMINATED FORMS OF UTERINE CERVIX CANCER
Uterine cervical cancer is among the main items of modern oncology. Determination of SCCA levels in blood serum of women with locally disseminated forms of uterine cervical cancer has a great significance for estimation the extent of lesions, tumor progression patterns, as well as treatment monitori...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/209 |
| _version_ | 1797198108481814528 |
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| author | I. L. Baturina I. Yu. Orner O. S. Abramovskikh L. F. Telesheva A. V, Zharov K. V. Nikushkina |
| author_facet | I. L. Baturina I. Yu. Orner O. S. Abramovskikh L. F. Telesheva A. V, Zharov K. V. Nikushkina |
| author_sort | I. L. Baturina |
| collection | DOAJ |
| description | Uterine cervical cancer is among the main items of modern oncology. Determination of SCCA levels in blood serum of women with locally disseminated forms of uterine cervical cancer has a great significance for estimation the extent of lesions, tumor progression patterns, as well as treatment monitoring. During our study, we have determined that, before starting a specific treatment, all the patients with locally disseminated forms of cervical cancer had high serum levels of SCCA, along with suppressed anti-tumor immunity.Interestingly, high SCCA levels in blood serum proved to correlate with a decrease in anti-tumor immunity factors in those patients who showed a negative dynamics of tumor progression within one year after the therapy was performed. Meanwhile, the patients with positive post-treatment dynamics exhibited a significant decrease of SCCA levels over a year after therapy, as compared with appropriate pre-treatment values, accompanied by increase in anti-tumor immunity markers in these cases. |
| first_indexed | 2024-03-08T05:51:51Z |
| format | Article |
| id | doaj.art-a6b868196a97417698c84131266ccac4 |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-04-24T06:54:37Z |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-a6b868196a97417698c84131266ccac42024-04-22T13:07:34ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-01124-538739210.15789/1563-0625-2010-4-5-387-392206RELATIONSHIP BETWEEN T CELL IMMUNITY PARAMETERS AND SMOOTH-CELL CARCINOMA ANTIGEN (SCCA) CONTENTS IN BLOOD SERUM FROM THE PATIENTS WITH LOCAL DISSEMINATED FORMS OF UTERINE CERVIX CANCERI. L. Baturina0I. Yu. Orner1O. S. Abramovskikh2L. F. Telesheva3A. V, Zharov4K. V. Nikushkina5ГОУ ВПО «Челябинская государственная медицинская академия» Росздрава, НИИ иммунологии, лаборатория иммунодефицитных состояний, г. ЧелябинскГОУ ВПО «Челябинская государственная медицинская академия» Росздрава, НИИ иммунологии, лаборатория иммунодефицитных состояний, г. ЧелябинскГОУ ВПО «Челябинская государственная медицинская академия» Росздрава, НИИ иммунологии, лаборатория иммунодефицитных состояний, г. ЧелябинскГОУ ВПО «Челябинская государственная медицинская академия» Росздрава, НИИ иммунологии, лаборатория иммунодефицитных состояний, г. ЧелябинскГОУ ВПО «Челябинская государственная медицинская академия» Росздрава, НИИ иммунологии, лаборатория иммунодефицитных состояний, г. ЧелябинскГОУ ВПО «Челябинская государственная медицинская академия» Росздрава, НИИ иммунологии, лаборатория иммунодефицитных состояний, г. ЧелябинскUterine cervical cancer is among the main items of modern oncology. Determination of SCCA levels in blood serum of women with locally disseminated forms of uterine cervical cancer has a great significance for estimation the extent of lesions, tumor progression patterns, as well as treatment monitoring. During our study, we have determined that, before starting a specific treatment, all the patients with locally disseminated forms of cervical cancer had high serum levels of SCCA, along with suppressed anti-tumor immunity.Interestingly, high SCCA levels in blood serum proved to correlate with a decrease in anti-tumor immunity factors in those patients who showed a negative dynamics of tumor progression within one year after the therapy was performed. Meanwhile, the patients with positive post-treatment dynamics exhibited a significant decrease of SCCA levels over a year after therapy, as compared with appropriate pre-treatment values, accompanied by increase in anti-tumor immunity markers in these cases.https://www.mimmun.ru/mimmun/article/view/209scctcell immunitycervical cancer |
| spellingShingle | I. L. Baturina I. Yu. Orner O. S. Abramovskikh L. F. Telesheva A. V, Zharov K. V. Nikushkina RELATIONSHIP BETWEEN T CELL IMMUNITY PARAMETERS AND SMOOTH-CELL CARCINOMA ANTIGEN (SCCA) CONTENTS IN BLOOD SERUM FROM THE PATIENTS WITH LOCAL DISSEMINATED FORMS OF UTERINE CERVIX CANCER Медицинская иммунология scc tcell immunity cervical cancer |
| title | RELATIONSHIP BETWEEN T CELL IMMUNITY PARAMETERS AND SMOOTH-CELL CARCINOMA ANTIGEN (SCCA) CONTENTS IN BLOOD SERUM FROM THE PATIENTS WITH LOCAL DISSEMINATED FORMS OF UTERINE CERVIX CANCER |
| title_full | RELATIONSHIP BETWEEN T CELL IMMUNITY PARAMETERS AND SMOOTH-CELL CARCINOMA ANTIGEN (SCCA) CONTENTS IN BLOOD SERUM FROM THE PATIENTS WITH LOCAL DISSEMINATED FORMS OF UTERINE CERVIX CANCER |
| title_fullStr | RELATIONSHIP BETWEEN T CELL IMMUNITY PARAMETERS AND SMOOTH-CELL CARCINOMA ANTIGEN (SCCA) CONTENTS IN BLOOD SERUM FROM THE PATIENTS WITH LOCAL DISSEMINATED FORMS OF UTERINE CERVIX CANCER |
| title_full_unstemmed | RELATIONSHIP BETWEEN T CELL IMMUNITY PARAMETERS AND SMOOTH-CELL CARCINOMA ANTIGEN (SCCA) CONTENTS IN BLOOD SERUM FROM THE PATIENTS WITH LOCAL DISSEMINATED FORMS OF UTERINE CERVIX CANCER |
| title_short | RELATIONSHIP BETWEEN T CELL IMMUNITY PARAMETERS AND SMOOTH-CELL CARCINOMA ANTIGEN (SCCA) CONTENTS IN BLOOD SERUM FROM THE PATIENTS WITH LOCAL DISSEMINATED FORMS OF UTERINE CERVIX CANCER |
| title_sort | relationship between t cell immunity parameters and smooth cell carcinoma antigen scca contents in blood serum from the patients with local disseminated forms of uterine cervix cancer |
| topic | scc tcell immunity cervical cancer |
| url | https://www.mimmun.ru/mimmun/article/view/209 |
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