The association of codon 392 polymorphism in ESR2 gene with breast cancer in Iran
Epidemiological studies revealed that the pattern of age onset of breast cancer in the Middle East region differ from those in Caucasians. Therefore, genomic data for ESR2 (ER-?) is of the value in the clinical setting for that ethnic group and the aim of the current investigation is investigated wh...
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| Format: | Article |
| Language: | English |
| Published: |
Sulaimani Polytechnic University
2019-12-01
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| Series: | Kurdistan Journal of Applied Research |
| Subjects: | |
| Online Access: | https://kjar.spu.edu.iq/index.php/kjar/article/view/419 |
| _version_ | 1797197688744181760 |
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| author | Sakineh Abbasi Samira Kalbasi |
| author_facet | Sakineh Abbasi Samira Kalbasi |
| author_sort | Sakineh Abbasi |
| collection | DOAJ |
| description | Epidemiological studies revealed that the pattern of age onset of breast cancer in the Middle East region differ from those in Caucasians. Therefore, genomic data for ESR2 (ER-?) is of the value in the clinical setting for that ethnic group and the aim of the current investigation is investigated whether polymorphisms in the ER-? gene are associated with breast cancer risk among Iranian women. The coding sequence in Exon 7 at ESR2 gene was looking for any variation among the Iranian breast cancer women by SSCP-PCR method. In codon 392 of exon 7, showed a silent SNP (silent single nucleotide polymorphism). The frequency of allele G in codon 392 (CTC ? CTG was found only in cases (5.7%). We also found that allele G in codon 392 (C1176G) had direct association with development of lymph node metastasis in breast cancer. The current results suggest that ESR2 SNP in exon 7, codon 392 is associated with various aspects of breast cancer in Iran. ESR2 gene structure determination, in presurgical evaluation, might be a useful marker in predicting familial breast cancer and metastasis in LN.
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| first_indexed | 2024-03-07T14:10:58Z |
| format | Article |
| id | doaj.art-a6b92487adaf4f0baa4ed3a2f82c1b62 |
| institution | Directory Open Access Journal |
| issn | 2411-7684 2411-7706 |
| language | English |
| last_indexed | 2024-04-24T06:47:57Z |
| publishDate | 2019-12-01 |
| publisher | Sulaimani Polytechnic University |
| record_format | Article |
| series | Kurdistan Journal of Applied Research |
| spelling | doaj.art-a6b92487adaf4f0baa4ed3a2f82c1b622024-04-22T17:19:19ZengSulaimani Polytechnic UniversityKurdistan Journal of Applied Research2411-76842411-77062019-12-0110.24017/science.2019.ICHMS.26419The association of codon 392 polymorphism in ESR2 gene with breast cancer in IranSakineh Abbasi0Samira Kalbasi1Department of Medical Laboratory Sciences School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, IranDepartment small pets, Faculty of Veterinary Medicine, University of Tehran, Tehran, IranEpidemiological studies revealed that the pattern of age onset of breast cancer in the Middle East region differ from those in Caucasians. Therefore, genomic data for ESR2 (ER-?) is of the value in the clinical setting for that ethnic group and the aim of the current investigation is investigated whether polymorphisms in the ER-? gene are associated with breast cancer risk among Iranian women. The coding sequence in Exon 7 at ESR2 gene was looking for any variation among the Iranian breast cancer women by SSCP-PCR method. In codon 392 of exon 7, showed a silent SNP (silent single nucleotide polymorphism). The frequency of allele G in codon 392 (CTC ? CTG was found only in cases (5.7%). We also found that allele G in codon 392 (C1176G) had direct association with development of lymph node metastasis in breast cancer. The current results suggest that ESR2 SNP in exon 7, codon 392 is associated with various aspects of breast cancer in Iran. ESR2 gene structure determination, in presurgical evaluation, might be a useful marker in predicting familial breast cancer and metastasis in LN. https://kjar.spu.edu.iq/index.php/kjar/article/view/419Breast cancer, estrogen receptor-β (ESR2), polymorphism, metastases, PCR-SSCP. |
| spellingShingle | Sakineh Abbasi Samira Kalbasi The association of codon 392 polymorphism in ESR2 gene with breast cancer in Iran Kurdistan Journal of Applied Research Breast cancer, estrogen receptor-β (ESR2), polymorphism, metastases, PCR-SSCP. |
| title | The association of codon 392 polymorphism in ESR2 gene with breast cancer in Iran |
| title_full | The association of codon 392 polymorphism in ESR2 gene with breast cancer in Iran |
| title_fullStr | The association of codon 392 polymorphism in ESR2 gene with breast cancer in Iran |
| title_full_unstemmed | The association of codon 392 polymorphism in ESR2 gene with breast cancer in Iran |
| title_short | The association of codon 392 polymorphism in ESR2 gene with breast cancer in Iran |
| title_sort | association of codon 392 polymorphism in esr2 gene with breast cancer in iran |
| topic | Breast cancer, estrogen receptor-β (ESR2), polymorphism, metastases, PCR-SSCP. |
| url | https://kjar.spu.edu.iq/index.php/kjar/article/view/419 |
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