Effect of levothyroxine on the development of preterm infants
Background: In preterm infants, thyroid disorders are very common but transient, and the cord blood T4 concentration is lower in preterm infants, compared to term infants, and its rate is usually related to gestational age and birth weight. And the effect of Levothyroxine on the nervous system devel...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-03-01
|
| Series: | Global Pediatrics |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667009722000264 |
| _version_ | 1827876738973040640 |
|---|---|
| author | Mahtab Ordooei Reihane Ranjbar Jamalabadi Seyed Reza Mirjalili Mahmood Noori Shadkam Razieh Fallah |
| author_facet | Mahtab Ordooei Reihane Ranjbar Jamalabadi Seyed Reza Mirjalili Mahmood Noori Shadkam Razieh Fallah |
| author_sort | Mahtab Ordooei |
| collection | DOAJ |
| description | Background: In preterm infants, thyroid disorders are very common but transient, and the cord blood T4 concentration is lower in preterm infants, compared to term infants, and its rate is usually related to gestational age and birth weight. And the effect of Levothyroxine on the nervous system development of preterm infants is still unclear. Aims: We aimed to evaluate Effect of Levothyroxine on the Development of Preterm Infants. Methods: Newborn infants born with GA <33, if TSH <10, were classified into two groups, which one was just monitored (control group), and in the other group, treatment was started using Levothyroxine (5 μg / kg) and continued up to the age of six weeks (case group). At the ages of four and six months, the ASQ test was performed to assess nervous system development. Results: There was no significant difference in the growth parameters of both groups. Moreover, there was no significant difference in different areas of Neurodevelopment of both groups. Conclusions: According to the research results, after 4 and 6 months, no significant difference was observed between the gross motor, fine motor, problem-solving, individual-social, and establishing communication areas of both case and control groups. Both mean ASQ scores, after 4 and 6 months, and neonatal growth parameters were not affected by Levothyroxine. |
| first_indexed | 2024-03-12T17:25:45Z |
| format | Article |
| id | doaj.art-a6b9fc7c02314050b9098e794f5570ac |
| institution | Directory Open Access Journal |
| issn | 2667-0097 |
| language | English |
| last_indexed | 2024-03-12T17:25:45Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Global Pediatrics |
| spelling | doaj.art-a6b9fc7c02314050b9098e794f5570ac2023-08-05T05:18:04ZengElsevierGlobal Pediatrics2667-00972023-03-013100032Effect of levothyroxine on the development of preterm infantsMahtab Ordooei0Reihane Ranjbar Jamalabadi1Seyed Reza Mirjalili2Mahmood Noori Shadkam3Razieh Fallah4Department of Pediatrics, Shahid Sadoughi University of Medical Science, Yazd, IranCorresponding author.; Department of Pediatrics, Shahid Sadoughi University of Medical Science, Yazd, IranDepartment of Pediatrics, Shahid Sadoughi University of Medical Science, Yazd, IranDepartment of Pediatrics, Shahid Sadoughi University of Medical Science, Yazd, IranDepartment of Pediatrics, Shahid Sadoughi University of Medical Science, Yazd, IranBackground: In preterm infants, thyroid disorders are very common but transient, and the cord blood T4 concentration is lower in preterm infants, compared to term infants, and its rate is usually related to gestational age and birth weight. And the effect of Levothyroxine on the nervous system development of preterm infants is still unclear. Aims: We aimed to evaluate Effect of Levothyroxine on the Development of Preterm Infants. Methods: Newborn infants born with GA <33, if TSH <10, were classified into two groups, which one was just monitored (control group), and in the other group, treatment was started using Levothyroxine (5 μg / kg) and continued up to the age of six weeks (case group). At the ages of four and six months, the ASQ test was performed to assess nervous system development. Results: There was no significant difference in the growth parameters of both groups. Moreover, there was no significant difference in different areas of Neurodevelopment of both groups. Conclusions: According to the research results, after 4 and 6 months, no significant difference was observed between the gross motor, fine motor, problem-solving, individual-social, and establishing communication areas of both case and control groups. Both mean ASQ scores, after 4 and 6 months, and neonatal growth parameters were not affected by Levothyroxine.http://www.sciencedirect.com/science/article/pii/S2667009722000264LevothyroxinePreterm infantsNeurodevelopmentASQ |
| spellingShingle | Mahtab Ordooei Reihane Ranjbar Jamalabadi Seyed Reza Mirjalili Mahmood Noori Shadkam Razieh Fallah Effect of levothyroxine on the development of preterm infants Global Pediatrics Levothyroxine Preterm infants Neurodevelopment ASQ |
| title | Effect of levothyroxine on the development of preterm infants |
| title_full | Effect of levothyroxine on the development of preterm infants |
| title_fullStr | Effect of levothyroxine on the development of preterm infants |
| title_full_unstemmed | Effect of levothyroxine on the development of preterm infants |
| title_short | Effect of levothyroxine on the development of preterm infants |
| title_sort | effect of levothyroxine on the development of preterm infants |
| topic | Levothyroxine Preterm infants Neurodevelopment ASQ |
| url | http://www.sciencedirect.com/science/article/pii/S2667009722000264 |
| work_keys_str_mv | AT mahtabordooei effectoflevothyroxineonthedevelopmentofpreterminfants AT reihaneranjbarjamalabadi effectoflevothyroxineonthedevelopmentofpreterminfants AT seyedrezamirjalili effectoflevothyroxineonthedevelopmentofpreterminfants AT mahmoodnoorishadkam effectoflevothyroxineonthedevelopmentofpreterminfants AT raziehfallah effectoflevothyroxineonthedevelopmentofpreterminfants |