Air quality, meteorological variability and pediatric respiratory syncytial virus infections in Singapore
Abstract Respiratory syncytial virus (RSV) is an important cause of respiratory illness among children. While studies have focused on the air-quality and climate dependence of RSV infections, few have been undertaken in South-East Asia where the burden of respiratory illness is among the highest acr...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-26184-0 |
| _version_ | 1797945894766641152 |
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| author | Meng Han Lee Diyar Mailepessov Khairunnisa Yahya Liat Hui Loo Matthias Maiwald Joel Aik |
| author_facet | Meng Han Lee Diyar Mailepessov Khairunnisa Yahya Liat Hui Loo Matthias Maiwald Joel Aik |
| author_sort | Meng Han Lee |
| collection | DOAJ |
| description | Abstract Respiratory syncytial virus (RSV) is an important cause of respiratory illness among children. While studies have focused on the air-quality and climate dependence of RSV infections, few have been undertaken in South-East Asia where the burden of respiratory illness is among the highest across the globe. This study aimed to determine the relationships between climatic factors and air quality with RSV infections among children in Singapore. We obtained all laboratory-confirmed reports of RSV infections in children below 5 years old from the largest public hospital specializing in pediatric healthcare in Singapore. We assessed the independent cumulative effects of air quality and meteorological factors on RSV infection risk using the Distributed Lag Non-Linear Model (DLNM) framework in negative binomial models adjusted for long-term trend, seasonality and changes in the diagnostic systems. We included 15,715 laboratory-confirmed RSV reports from 2009 to 2019. Daily maximum temperature exhibited a complex, non-linear association with RSV infections. Absolute humidity (Relative Risk, 90th percentile [RR90th percentile]: 1.170, 95% CI: [1.102, 1.242]) was positively associated with RSV risk. Higher levels of particulate matter of aerodynamic diameter of less than (i) 2.5 µm (PM2.5), (ii) 10 µm (PM10), carbon monoxide (CO) and sulfur dioxide (SO2) were associated with lower RSV infection risk. RSV infections exhibited both annual and within-year seasonality. Our findings suggest that falls in ambient temperature and rises in absolute humidity exacerbated pediatric RSV infection risk while increases in air pollutant concentrations were associated with lowered infection risk. These meteorological factors, together with the predictable seasonality of RSV infections, can inform the timing of mitigation measures aimed at reducing transmission. |
| first_indexed | 2024-04-10T21:02:21Z |
| format | Article |
| id | doaj.art-a6baeac4fff94c29b0c6249bd7fddd10 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-10T21:02:21Z |
| publishDate | 2023-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-a6baeac4fff94c29b0c6249bd7fddd102023-01-22T12:14:30ZengNature PortfolioScientific Reports2045-23222023-01-0113111010.1038/s41598-022-26184-0Air quality, meteorological variability and pediatric respiratory syncytial virus infections in SingaporeMeng Han Lee0Diyar Mailepessov1Khairunnisa Yahya2Liat Hui Loo3Matthias Maiwald4Joel Aik5Environmental Epidemiology and Toxicology Division, National Environment AgencyEnvironmental Epidemiology and Toxicology Division, National Environment AgencyEnvironmental Monitoring and Modelling Division, National Environment AgencyDepartment of Pathology and Laboratory Medicine, KK Women’s and Children’s HospitalDepartment of Pathology and Laboratory Medicine, KK Women’s and Children’s HospitalEnvironmental Epidemiology and Toxicology Division, National Environment AgencyAbstract Respiratory syncytial virus (RSV) is an important cause of respiratory illness among children. While studies have focused on the air-quality and climate dependence of RSV infections, few have been undertaken in South-East Asia where the burden of respiratory illness is among the highest across the globe. This study aimed to determine the relationships between climatic factors and air quality with RSV infections among children in Singapore. We obtained all laboratory-confirmed reports of RSV infections in children below 5 years old from the largest public hospital specializing in pediatric healthcare in Singapore. We assessed the independent cumulative effects of air quality and meteorological factors on RSV infection risk using the Distributed Lag Non-Linear Model (DLNM) framework in negative binomial models adjusted for long-term trend, seasonality and changes in the diagnostic systems. We included 15,715 laboratory-confirmed RSV reports from 2009 to 2019. Daily maximum temperature exhibited a complex, non-linear association with RSV infections. Absolute humidity (Relative Risk, 90th percentile [RR90th percentile]: 1.170, 95% CI: [1.102, 1.242]) was positively associated with RSV risk. Higher levels of particulate matter of aerodynamic diameter of less than (i) 2.5 µm (PM2.5), (ii) 10 µm (PM10), carbon monoxide (CO) and sulfur dioxide (SO2) were associated with lower RSV infection risk. RSV infections exhibited both annual and within-year seasonality. Our findings suggest that falls in ambient temperature and rises in absolute humidity exacerbated pediatric RSV infection risk while increases in air pollutant concentrations were associated with lowered infection risk. These meteorological factors, together with the predictable seasonality of RSV infections, can inform the timing of mitigation measures aimed at reducing transmission.https://doi.org/10.1038/s41598-022-26184-0 |
| spellingShingle | Meng Han Lee Diyar Mailepessov Khairunnisa Yahya Liat Hui Loo Matthias Maiwald Joel Aik Air quality, meteorological variability and pediatric respiratory syncytial virus infections in Singapore Scientific Reports |
| title | Air quality, meteorological variability and pediatric respiratory syncytial virus infections in Singapore |
| title_full | Air quality, meteorological variability and pediatric respiratory syncytial virus infections in Singapore |
| title_fullStr | Air quality, meteorological variability and pediatric respiratory syncytial virus infections in Singapore |
| title_full_unstemmed | Air quality, meteorological variability and pediatric respiratory syncytial virus infections in Singapore |
| title_short | Air quality, meteorological variability and pediatric respiratory syncytial virus infections in Singapore |
| title_sort | air quality meteorological variability and pediatric respiratory syncytial virus infections in singapore |
| url | https://doi.org/10.1038/s41598-022-26184-0 |
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