Features and risk factors for recurrence of intradural spinal tumors
Spinal cord tumors include a variety of nosological units and are classified according to their localization and histological type. The search for literature sources in the Pubmed, EMBASE and eLibrary databases demonstrated the absence of studies devoted to study of the features and risk factors for...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2019-02-01
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| Series: | Сибирский онкологический журнал |
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| Online Access: | https://www.siboncoj.ru/jour/article/view/955 |
| _version_ | 1797875811261349888 |
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| author | V. A. Byvaltsev I. A. Stepanov |
| author_facet | V. A. Byvaltsev I. A. Stepanov |
| author_sort | V. A. Byvaltsev |
| collection | DOAJ |
| description | Spinal cord tumors include a variety of nosological units and are classified according to their localization and histological type. The search for literature sources in the Pubmed, EMBASE and eLibrary databases demonstrated the absence of studies devoted to study of the features and risk factors for the recurrence of intradural spinal tumors. the purpose of this study was to reveal features and risk factors of recurrence of intradural spinal tumors after microneurosurgical resection. material and methods. The study included medical records of 196 patients with intradural extramedullary and intramedullary spinal tumors. The extent of microneurosurgical tumor resection, clinical efficacy of surgery, and risk factors for recurrence of intradural spinal cord tumors were been analyzed. results. Improvement in neurologic deficit after surgery was noted in 116 (59.1 %) cases, neurologic status remained the same in 47 (24.0 %) patients, and worsening of neurological deficit was observed in 33 (16.8 %) cases. Total microneurosurgical resection of intradural spinal tumors was performed in 140 (71.4 %) patients, subtotal resection in 22 (11.2 %) patients, partial resection in 25 (12.7 %) patients and spinal cord decompression or biopsy and/or its roots were performed in 9 (4.6 %) of patients. The likelihood of recurrence-free survival of patients with benign intradural spinal cord tumors was significantly higher than that of patients with malignant tumors (p<0.001). Benign tumors (χ2=34.7, p<0.05), thoracic and lumbosacral tumors (χ2=10.3, p<0.05), low degree of neurological deficit (χ2=31.5, p<0.05), absence of syringomyelia/syringobulbia signs (χ2=13,2, p<0,05), as well as extramedullary tumors (χ2=12,6, p<0.05) allowed us to perform total degree microneurosurgical resection. Malignant tumors (χ2=34.8, p<0.05), cervical and thoracic tumors (χ2=8,4, p<0,05), high degree of neurological deficit (χ2=12,9, p<0.05), partial resection, biopsy or decompression of neural structures (χ2=9.7, p<0.05) and intramedullary tumors statistically significantly increased the risk of their recurrence. conclusion. Histological pattern, tumor localization, preoperative clinical and neurological deficit according to the McCormick classification and the extent of surgery are significant risk factors for recurrence of intradural spinal tumors. |
| first_indexed | 2024-04-10T01:53:32Z |
| format | Article |
| id | doaj.art-a6baffd2b2954e85bad19ebb5a473bc0 |
| institution | Directory Open Access Journal |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| last_indexed | 2024-04-10T01:53:32Z |
| publishDate | 2019-02-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj.art-a6baffd2b2954e85bad19ebb5a473bc02023-03-13T09:05:52ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682019-02-01181212910.21294/1814-4861-2019-18-1-21-29607Features and risk factors for recurrence of intradural spinal tumorsV. A. Byvaltsev0I. A. Stepanov1ФГБОУ ВО «Иркутский государственный медицинский университет»; НУЗ «Дорожная клиническая больница на ст. Иркутск-Пассажирский; ФГБНУ «Иркутский научный центр хирургии и травматологии»; ФГБОУ ДПО «Иркутская государственная медицинская академия последипломного образования»ФГБОУ ВО «Иркутский государственный медицинский университет»Spinal cord tumors include a variety of nosological units and are classified according to their localization and histological type. The search for literature sources in the Pubmed, EMBASE and eLibrary databases demonstrated the absence of studies devoted to study of the features and risk factors for the recurrence of intradural spinal tumors. the purpose of this study was to reveal features and risk factors of recurrence of intradural spinal tumors after microneurosurgical resection. material and methods. The study included medical records of 196 patients with intradural extramedullary and intramedullary spinal tumors. The extent of microneurosurgical tumor resection, clinical efficacy of surgery, and risk factors for recurrence of intradural spinal cord tumors were been analyzed. results. Improvement in neurologic deficit after surgery was noted in 116 (59.1 %) cases, neurologic status remained the same in 47 (24.0 %) patients, and worsening of neurological deficit was observed in 33 (16.8 %) cases. Total microneurosurgical resection of intradural spinal tumors was performed in 140 (71.4 %) patients, subtotal resection in 22 (11.2 %) patients, partial resection in 25 (12.7 %) patients and spinal cord decompression or biopsy and/or its roots were performed in 9 (4.6 %) of patients. The likelihood of recurrence-free survival of patients with benign intradural spinal cord tumors was significantly higher than that of patients with malignant tumors (p<0.001). Benign tumors (χ2=34.7, p<0.05), thoracic and lumbosacral tumors (χ2=10.3, p<0.05), low degree of neurological deficit (χ2=31.5, p<0.05), absence of syringomyelia/syringobulbia signs (χ2=13,2, p<0,05), as well as extramedullary tumors (χ2=12,6, p<0.05) allowed us to perform total degree microneurosurgical resection. Malignant tumors (χ2=34.8, p<0.05), cervical and thoracic tumors (χ2=8,4, p<0,05), high degree of neurological deficit (χ2=12,9, p<0.05), partial resection, biopsy or decompression of neural structures (χ2=9.7, p<0.05) and intramedullary tumors statistically significantly increased the risk of their recurrence. conclusion. Histological pattern, tumor localization, preoperative clinical and neurological deficit according to the McCormick classification and the extent of surgery are significant risk factors for recurrence of intradural spinal tumors.https://www.siboncoj.ru/jour/article/view/955интрадуральные опухоли спинного мозгамикронейрохирургическая резекциярецидивированиефакторы рискаклинико-морфологические особенности |
| spellingShingle | V. A. Byvaltsev I. A. Stepanov Features and risk factors for recurrence of intradural spinal tumors Сибирский онкологический журнал интрадуральные опухоли спинного мозга микронейрохирургическая резекция рецидивирование факторы риска клинико-морфологические особенности |
| title | Features and risk factors for recurrence of intradural spinal tumors |
| title_full | Features and risk factors for recurrence of intradural spinal tumors |
| title_fullStr | Features and risk factors for recurrence of intradural spinal tumors |
| title_full_unstemmed | Features and risk factors for recurrence of intradural spinal tumors |
| title_short | Features and risk factors for recurrence of intradural spinal tumors |
| title_sort | features and risk factors for recurrence of intradural spinal tumors |
| topic | интрадуральные опухоли спинного мозга микронейрохирургическая резекция рецидивирование факторы риска клинико-морфологические особенности |
| url | https://www.siboncoj.ru/jour/article/view/955 |
| work_keys_str_mv | AT vabyvaltsev featuresandriskfactorsforrecurrenceofintraduralspinaltumors AT iastepanov featuresandriskfactorsforrecurrenceofintraduralspinaltumors |