Comparative assessment of erythrocyte sphingolipid levels as potential cardiovascular health markers in women from Libya and Serbia: a small-scale study
ABSTRACTAim: Cardiovascular diseases (CVDs) represent the major cause of morbidity and mortality worldwide including Libya, where they account for 43% of all deaths. Sphingolipids are involved in the pathology of numerous diseases including cardiovascular diseases and are proposed as potential bioma...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Libyan Journal of Medicine |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/19932820.2023.2264568 |
| _version_ | 1797450050174976000 |
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| author | Nevena Vidović Marija Knez Marija Ranić Fathia Faid Dragana Jović Marija Glibetic Marija Takić |
| author_facet | Nevena Vidović Marija Knez Marija Ranić Fathia Faid Dragana Jović Marija Glibetic Marija Takić |
| author_sort | Nevena Vidović |
| collection | DOAJ |
| description | ABSTRACTAim: Cardiovascular diseases (CVDs) represent the major cause of morbidity and mortality worldwide including Libya, where they account for 43% of all deaths. Sphingolipids are involved in the pathology of numerous diseases including cardiovascular diseases and are proposed as potential biomarkers of cardiovascular health that could be more effective compared to traditional clinical biomarkers. The aim of this study was to determine the sphingolipid content in the erythrocyte membrane of Libyan migrant and Serbian resident women. In addition, to examine if sphingolipid levels could be used as a novel indicator of cardiovascular risk, we evaluated possible correlations with some well-established biomarkers of cardiovascular health.Materials and Methods: A total of 13 Libyan and 15 Serbian healthy women participated in the study. The high-performance version thin-layer chromatography (HPTLC) using the image analysis tool JustTLC was applied for quantification of erythrocytes’ sphingolipids.Results: Lower mean values of erythrocytes’ sphingolipids and cholesterol concentrations were found in the group of Libyan emigrants compared to Serbian resident women. Besides, in this group of apparently healthy women (n = 28), the sphingolipid content of erythrocytes was inversely related to the Omega-3 index (r =-0.492, p = 0.008) and directly linked to vitamin D status (r = 0.433, p = 0.021) and membrane cholesterol levels (r = 0.474, p = 0.011).Conclusion: The erythrocytes’ sphingolipid levels should be measured/assessed as an additional biomarker of CV health, by applying a simple and routine method. Still, further investigation in a larger population-specific context is warranted. |
| first_indexed | 2024-03-09T14:34:54Z |
| format | Article |
| id | doaj.art-a6bb54a7c65c4a7c8c9636e3c45af006 |
| institution | Directory Open Access Journal |
| issn | 1993-2820 1819-6357 |
| language | English |
| last_indexed | 2024-03-09T14:34:54Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Libyan Journal of Medicine |
| spelling | doaj.art-a6bb54a7c65c4a7c8c9636e3c45af0062023-11-27T14:59:05ZengTaylor & Francis GroupLibyan Journal of Medicine1993-28201819-63572023-12-0118110.1080/19932820.2023.2264568Comparative assessment of erythrocyte sphingolipid levels as potential cardiovascular health markers in women from Libya and Serbia: a small-scale studyNevena Vidović0Marija Knez1Marija Ranić2Fathia Faid3Dragana Jović4Marija Glibetic5Marija Takić6Institute for Medical Research, National Institute of Republic of Serbia, Centre of Research Excellence in Nutrition and Metabolism, University of Belgrade, Belgrade, SerbiaInstitute for Medical Research, National Institute of Republic of Serbia, Centre of Research Excellence in Nutrition and Metabolism, University of Belgrade, Belgrade, SerbiaInstitute for Medical Research, National Institute of Republic of Serbia, Centre of Research Excellence in Nutrition and Metabolism, University of Belgrade, Belgrade, SerbiaInstitute for Medical Research, National Institute of Republic of Serbia, Centre of Research Excellence in Nutrition and Metabolism, University of Belgrade, Belgrade, SerbiaCenter for Hygiene and Human Ecology, Institute of Public Health of Serbia “Dr Milan Jovanović Batut”, Belgrade, SerbiaInstitute for Medical Research, National Institute of Republic of Serbia, Centre of Research Excellence in Nutrition and Metabolism, University of Belgrade, Belgrade, SerbiaInstitute for Medical Research, National Institute of Republic of Serbia, Centre of Research Excellence in Nutrition and Metabolism, University of Belgrade, Belgrade, SerbiaABSTRACTAim: Cardiovascular diseases (CVDs) represent the major cause of morbidity and mortality worldwide including Libya, where they account for 43% of all deaths. Sphingolipids are involved in the pathology of numerous diseases including cardiovascular diseases and are proposed as potential biomarkers of cardiovascular health that could be more effective compared to traditional clinical biomarkers. The aim of this study was to determine the sphingolipid content in the erythrocyte membrane of Libyan migrant and Serbian resident women. In addition, to examine if sphingolipid levels could be used as a novel indicator of cardiovascular risk, we evaluated possible correlations with some well-established biomarkers of cardiovascular health.Materials and Methods: A total of 13 Libyan and 15 Serbian healthy women participated in the study. The high-performance version thin-layer chromatography (HPTLC) using the image analysis tool JustTLC was applied for quantification of erythrocytes’ sphingolipids.Results: Lower mean values of erythrocytes’ sphingolipids and cholesterol concentrations were found in the group of Libyan emigrants compared to Serbian resident women. Besides, in this group of apparently healthy women (n = 28), the sphingolipid content of erythrocytes was inversely related to the Omega-3 index (r =-0.492, p = 0.008) and directly linked to vitamin D status (r = 0.433, p = 0.021) and membrane cholesterol levels (r = 0.474, p = 0.011).Conclusion: The erythrocytes’ sphingolipid levels should be measured/assessed as an additional biomarker of CV health, by applying a simple and routine method. Still, further investigation in a larger population-specific context is warranted.https://www.tandfonline.com/doi/10.1080/19932820.2023.2264568Cardiovascular healthLibyan womenmembrane cholesterolOmega-3 indexsphingolipidsvitamin D |
| spellingShingle | Nevena Vidović Marija Knez Marija Ranić Fathia Faid Dragana Jović Marija Glibetic Marija Takić Comparative assessment of erythrocyte sphingolipid levels as potential cardiovascular health markers in women from Libya and Serbia: a small-scale study Libyan Journal of Medicine Cardiovascular health Libyan women membrane cholesterol Omega-3 index sphingolipids vitamin D |
| title | Comparative assessment of erythrocyte sphingolipid levels as potential cardiovascular health markers in women from Libya and Serbia: a small-scale study |
| title_full | Comparative assessment of erythrocyte sphingolipid levels as potential cardiovascular health markers in women from Libya and Serbia: a small-scale study |
| title_fullStr | Comparative assessment of erythrocyte sphingolipid levels as potential cardiovascular health markers in women from Libya and Serbia: a small-scale study |
| title_full_unstemmed | Comparative assessment of erythrocyte sphingolipid levels as potential cardiovascular health markers in women from Libya and Serbia: a small-scale study |
| title_short | Comparative assessment of erythrocyte sphingolipid levels as potential cardiovascular health markers in women from Libya and Serbia: a small-scale study |
| title_sort | comparative assessment of erythrocyte sphingolipid levels as potential cardiovascular health markers in women from libya and serbia a small scale study |
| topic | Cardiovascular health Libyan women membrane cholesterol Omega-3 index sphingolipids vitamin D |
| url | https://www.tandfonline.com/doi/10.1080/19932820.2023.2264568 |
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