Opioids and immune checkpoint inhibitors differentially regulate a common immune network in triple-negative breast cancer

Opioids and immune checkpoint inhibitors differentially regulate a common immune network in triple-negative breast cancer

BackgroundOpioids are the primary analgesics for cancer pain. Recent clinical evidence suggests opioids may counteract the effect of immune checkpoint inhibition (ICI) immunotherapy, but the mechanism for this interaction is unknown. The following experiments study how opioids and immunotherapy modu...

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Bibliographic Details
Main Authors: Joseph R. Scarpa, Giacomo Montagna, George Plitas, Amitabh Gulati, Gregory W. Fischer, Joshua S. Mincer
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Oncology
Subjects:
opioids
ketamine
immune checkpoint inhibition
anti-PD-L1
tumor-infiltrating lymphocytes
triple-negative breast cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1267532/full

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