Prognostic Relevance of Tumor-Infiltrating Immune Cells in Cervix Squamous Cell Carcinoma
There exists a variety of studies about tumor-infiltrating immune cells (TIICs) in cervical cancer, but their prognostic value in correlation with the histopathological subtype has never been investigated. Therefore, the aim of this study was to quantify TIICs in a panel of 238 sporadic cervical can...
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MDPI AG
2023-10-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/20/4952 |
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| author | Carl Mathis Wild Fabian Garrido Christian Dannecker Melitta B. Köpke Marie-Christine Chateau Florence Boissière-Michot Helene H. Heidegger Aurelia Vattai Mirjana Kessler Udo Jeschke Vincent Cavaillès |
| author_facet | Carl Mathis Wild Fabian Garrido Christian Dannecker Melitta B. Köpke Marie-Christine Chateau Florence Boissière-Michot Helene H. Heidegger Aurelia Vattai Mirjana Kessler Udo Jeschke Vincent Cavaillès |
| author_sort | Carl Mathis Wild |
| collection | DOAJ |
| description | There exists a variety of studies about tumor-infiltrating immune cells (TIICs) in cervical cancer, but their prognostic value in correlation with the histopathological subtype has never been investigated. Therefore, the aim of this study was to quantify TIICs in a panel of 238 sporadic cervical cancers and investigate the correlation with cervical cancer subtype and patient survival. TIICs levels were significantly increased in the subgroup of CSCC (191 samples) in comparison to CAC (47 samples). In CSCC, TIICs’ infiltration showed a negative correlation with age, FIGO stage and with the histone protein modification H3K4me3. Moreover, in CAC, it was positively correlated with p16 and with the glucocorticoid receptor and inversely correlated with the MDM2 protein and with H3K4me3. Interestingly, immune infiltration was an independent positive prognosticator for disease-free survival (DFS) in patients with CSCC, those bearing tumors with the strongest TIICs infiltration showing the better DFS. Altogether, the present study provides a differentiated overview of the relations between TIIC levels and prognosis in patients with CSCC vs. patients with CAC. |
| first_indexed | 2024-03-10T21:22:46Z |
| format | Article |
| id | doaj.art-a6c1d06663b44af2b96529d13dd30923 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T21:22:46Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-a6c1d06663b44af2b96529d13dd309232023-11-19T15:58:27ZengMDPI AGCancers2072-66942023-10-011520495210.3390/cancers15204952Prognostic Relevance of Tumor-Infiltrating Immune Cells in Cervix Squamous Cell CarcinomaCarl Mathis Wild0Fabian Garrido1Christian Dannecker2Melitta B. Köpke3Marie-Christine Chateau4Florence Boissière-Michot5Helene H. Heidegger6Aurelia Vattai7Mirjana Kessler8Udo Jeschke9Vincent Cavaillès10Department of Obstetrics and Gynecology, University Hospital Augsburg, Stenglinstrasse 2, 86156 Augsburg, GermanyDepartment of Obstetrics and Gynecology, University Hospital Augsburg, Stenglinstrasse 2, 86156 Augsburg, GermanyDepartment of Obstetrics and Gynecology, University Hospital Augsburg, Stenglinstrasse 2, 86156 Augsburg, GermanyDepartment of Obstetrics and Gynecology, University Hospital Augsburg, Stenglinstrasse 2, 86156 Augsburg, GermanyTranslational Research Unit, Montpellier Cancer Institute Val d’Aurelle, 208 rue des Apothicaires, F-34298 Montpellier, FranceTranslational Research Unit, Montpellier Cancer Institute Val d’Aurelle, 208 rue des Apothicaires, F-34298 Montpellier, FranceDepartment of Obstetrics and Gynecology, University Hospital, LMU Munich, Marchioninistraße 15, 81377 Munich, GermanyDepartment of Obstetrics and Gynecology, University Hospital, LMU Munich, Marchioninistraße 15, 81377 Munich, GermanyDepartment of Obstetrics and Gynecology, University Hospital, LMU Munich, Marchioninistraße 15, 81377 Munich, GermanyDepartment of Obstetrics and Gynecology, University Hospital Augsburg, Stenglinstrasse 2, 86156 Augsburg, GermanyInstitut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Université Montpellier, CNRS, F-34298 Montpellier, FranceThere exists a variety of studies about tumor-infiltrating immune cells (TIICs) in cervical cancer, but their prognostic value in correlation with the histopathological subtype has never been investigated. Therefore, the aim of this study was to quantify TIICs in a panel of 238 sporadic cervical cancers and investigate the correlation with cervical cancer subtype and patient survival. TIICs levels were significantly increased in the subgroup of CSCC (191 samples) in comparison to CAC (47 samples). In CSCC, TIICs’ infiltration showed a negative correlation with age, FIGO stage and with the histone protein modification H3K4me3. Moreover, in CAC, it was positively correlated with p16 and with the glucocorticoid receptor and inversely correlated with the MDM2 protein and with H3K4me3. Interestingly, immune infiltration was an independent positive prognosticator for disease-free survival (DFS) in patients with CSCC, those bearing tumors with the strongest TIICs infiltration showing the better DFS. Altogether, the present study provides a differentiated overview of the relations between TIIC levels and prognosis in patients with CSCC vs. patients with CAC.https://www.mdpi.com/2072-6694/15/20/4952cervical cancertumor-infiltrating immune cells (TIICs)cervix adenocarcinoma (CAC)cervix squamous cell carcinoma (CSCC)disease-free survival (DFS)overall survival (OS) |
| spellingShingle | Carl Mathis Wild Fabian Garrido Christian Dannecker Melitta B. Köpke Marie-Christine Chateau Florence Boissière-Michot Helene H. Heidegger Aurelia Vattai Mirjana Kessler Udo Jeschke Vincent Cavaillès Prognostic Relevance of Tumor-Infiltrating Immune Cells in Cervix Squamous Cell Carcinoma Cancers cervical cancer tumor-infiltrating immune cells (TIICs) cervix adenocarcinoma (CAC) cervix squamous cell carcinoma (CSCC) disease-free survival (DFS) overall survival (OS) |
| title | Prognostic Relevance of Tumor-Infiltrating Immune Cells in Cervix Squamous Cell Carcinoma |
| title_full | Prognostic Relevance of Tumor-Infiltrating Immune Cells in Cervix Squamous Cell Carcinoma |
| title_fullStr | Prognostic Relevance of Tumor-Infiltrating Immune Cells in Cervix Squamous Cell Carcinoma |
| title_full_unstemmed | Prognostic Relevance of Tumor-Infiltrating Immune Cells in Cervix Squamous Cell Carcinoma |
| title_short | Prognostic Relevance of Tumor-Infiltrating Immune Cells in Cervix Squamous Cell Carcinoma |
| title_sort | prognostic relevance of tumor infiltrating immune cells in cervix squamous cell carcinoma |
| topic | cervical cancer tumor-infiltrating immune cells (TIICs) cervix adenocarcinoma (CAC) cervix squamous cell carcinoma (CSCC) disease-free survival (DFS) overall survival (OS) |
| url | https://www.mdpi.com/2072-6694/15/20/4952 |
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