Association of vitamin D receptor gene polymorphisms with response to peginterferon plus ribavirin in Asian patients with chronic hepatitis C
Recent studies have shown that serum vitamin D deficiency is a negative predictor of response to peginterferon plus ribavirin therapy for Caucasian patients with chronic hepatitis C (CHC). Whether vitamin D receptor (VDR) gene polymorphisms associate with antiviral response in Asian CHC patients rem...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2016-04-01
|
| Series: | Journal of the Formosan Medical Association |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664615003794 |
| _version_ | 1818117330886983680 |
|---|---|
| author | Chao-Hung Hung Tsung-Hui Hu Sheng-Nan Lu Chien-Hung Chen Jing-Houng Wang Chuan-Mo Lee |
| author_facet | Chao-Hung Hung Tsung-Hui Hu Sheng-Nan Lu Chien-Hung Chen Jing-Houng Wang Chuan-Mo Lee |
| author_sort | Chao-Hung Hung |
| collection | DOAJ |
| description | Recent studies have shown that serum vitamin D deficiency is a negative predictor of response to peginterferon plus ribavirin therapy for Caucasian patients with chronic hepatitis C (CHC). Whether vitamin D receptor (VDR) gene polymorphisms associate with antiviral response in Asian CHC patients remains unclear.
Methods: We recruited 139 Asian patients with CHC genotype-1 who achieved 80/80/80 adherence of response-guided peginterferon plus ribavirin therapy. BsmI rs1544410, ApaI rs7975232, and TaqI rs731236 were genotyped and related to clinical and virological features and to treatment outcome.
Results: Patients carrying bAt [CCA] haplotype (p=0.033), ApaI CC genotype (p = 0.033), and TaqI AA genotype (p = 0.037) had a higher HCV load as compared to those with other haplotypes, ApaI CA/AA genotype and TaqI AG genotype, respectively. A sustained virological response (SVR) was achieved in 74 (53%) of the patients. Polymorphisms in VDR gene did not correlate with rapid virological response and SVR achievement. Stepwise logistic regression analysis showed that rs12979860 CC type [odds ratio (OR): 5.56, p=0.007], platelet counts ≥ 15 × 1010/L (OR: 4.80, p=0.001), and rapid virological response achievement (OR: 8.36, p<0.001) were independent factors of SVR.
Conclusion: Despite their associations with high hepatitis C virus load, VDR gene polymorphisms are not related to the response to peginterferon plus ribavirin therapy in Asian CHC patients. |
| first_indexed | 2024-12-11T04:36:42Z |
| format | Article |
| id | doaj.art-a6c25c56419440059e40f1c77446be75 |
| institution | Directory Open Access Journal |
| issn | 0929-6646 |
| language | English |
| last_indexed | 2024-12-11T04:36:42Z |
| publishDate | 2016-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj.art-a6c25c56419440059e40f1c77446be752022-12-22T01:20:44ZengElsevierJournal of the Formosan Medical Association0929-66462016-04-01115427828310.1016/j.jfma.2015.11.008Association of vitamin D receptor gene polymorphisms with response to peginterferon plus ribavirin in Asian patients with chronic hepatitis CChao-Hung HungTsung-Hui HuSheng-Nan LuChien-Hung ChenJing-Houng WangChuan-Mo LeeRecent studies have shown that serum vitamin D deficiency is a negative predictor of response to peginterferon plus ribavirin therapy for Caucasian patients with chronic hepatitis C (CHC). Whether vitamin D receptor (VDR) gene polymorphisms associate with antiviral response in Asian CHC patients remains unclear. Methods: We recruited 139 Asian patients with CHC genotype-1 who achieved 80/80/80 adherence of response-guided peginterferon plus ribavirin therapy. BsmI rs1544410, ApaI rs7975232, and TaqI rs731236 were genotyped and related to clinical and virological features and to treatment outcome. Results: Patients carrying bAt [CCA] haplotype (p=0.033), ApaI CC genotype (p = 0.033), and TaqI AA genotype (p = 0.037) had a higher HCV load as compared to those with other haplotypes, ApaI CA/AA genotype and TaqI AG genotype, respectively. A sustained virological response (SVR) was achieved in 74 (53%) of the patients. Polymorphisms in VDR gene did not correlate with rapid virological response and SVR achievement. Stepwise logistic regression analysis showed that rs12979860 CC type [odds ratio (OR): 5.56, p=0.007], platelet counts ≥ 15 × 1010/L (OR: 4.80, p=0.001), and rapid virological response achievement (OR: 8.36, p<0.001) were independent factors of SVR. Conclusion: Despite their associations with high hepatitis C virus load, VDR gene polymorphisms are not related to the response to peginterferon plus ribavirin therapy in Asian CHC patients.http://www.sciencedirect.com/science/article/pii/S0929664615003794Asiahepatitis Cinterferonsustained virological responsevitamin D receptor |
| spellingShingle | Chao-Hung Hung Tsung-Hui Hu Sheng-Nan Lu Chien-Hung Chen Jing-Houng Wang Chuan-Mo Lee Association of vitamin D receptor gene polymorphisms with response to peginterferon plus ribavirin in Asian patients with chronic hepatitis C Journal of the Formosan Medical Association Asia hepatitis C interferon sustained virological response vitamin D receptor |
| title | Association of vitamin D receptor gene polymorphisms with response to peginterferon plus ribavirin in Asian patients with chronic hepatitis C |
| title_full | Association of vitamin D receptor gene polymorphisms with response to peginterferon plus ribavirin in Asian patients with chronic hepatitis C |
| title_fullStr | Association of vitamin D receptor gene polymorphisms with response to peginterferon plus ribavirin in Asian patients with chronic hepatitis C |
| title_full_unstemmed | Association of vitamin D receptor gene polymorphisms with response to peginterferon plus ribavirin in Asian patients with chronic hepatitis C |
| title_short | Association of vitamin D receptor gene polymorphisms with response to peginterferon plus ribavirin in Asian patients with chronic hepatitis C |
| title_sort | association of vitamin d receptor gene polymorphisms with response to peginterferon plus ribavirin in asian patients with chronic hepatitis c |
| topic | Asia hepatitis C interferon sustained virological response vitamin D receptor |
| url | http://www.sciencedirect.com/science/article/pii/S0929664615003794 |
| work_keys_str_mv | AT chaohunghung associationofvitamindreceptorgenepolymorphismswithresponsetopeginterferonplusribavirininasianpatientswithchronichepatitisc AT tsunghuihu associationofvitamindreceptorgenepolymorphismswithresponsetopeginterferonplusribavirininasianpatientswithchronichepatitisc AT shengnanlu associationofvitamindreceptorgenepolymorphismswithresponsetopeginterferonplusribavirininasianpatientswithchronichepatitisc AT chienhungchen associationofvitamindreceptorgenepolymorphismswithresponsetopeginterferonplusribavirininasianpatientswithchronichepatitisc AT jinghoungwang associationofvitamindreceptorgenepolymorphismswithresponsetopeginterferonplusribavirininasianpatientswithchronichepatitisc AT chuanmolee associationofvitamindreceptorgenepolymorphismswithresponsetopeginterferonplusribavirininasianpatientswithchronichepatitisc |