COMPARATIVE ANALYSIS OF THE DYNAMICS OF IMMUNE-ANTIOXIDANT STATUS OF THE ANTIOXIDANT SYSTEM IN PATIENTS SUFFERING FROM HYPOTHYROIDISM AND COPD
Aim. To carry out a comparative study of the features and shift tendency of individual indicators of the antioxidant system in patients with hypothyroidism and COPD of various phenotypes. 79 patients suffering from COPD III and IV were examined at the age of 60 to 80 years (men and women) who were h...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Ministry of Healthcare of the Russian Federation. “Kuban State Medical University”
2017-11-01
|
| Series: | Кубанский научный медицинский вестник |
| Subjects: | |
| Online Access: | https://ksma.elpub.ru/jour/article/view/881 |
| _version_ | 1797295490688090112 |
|---|---|
| author | I. I. PAVLUCHENKO E. I. DYDYSHKO O. S. OKHREMENKO |
| author_facet | I. I. PAVLUCHENKO E. I. DYDYSHKO O. S. OKHREMENKO |
| author_sort | I. I. PAVLUCHENKO |
| collection | DOAJ |
| description | Aim. To carry out a comparative study of the features and shift tendency of individual indicators of the antioxidant system in patients with hypothyroidism and COPD of various phenotypes. 79 patients suffering from COPD III and IV were examined at the age of 60 to 80 years (men and women) who were hospitalized in the pulmonology department of the Regional Clinical Hospital No. 2 in Krasnodar, along with 47 patients suffering from hypothyroidism.Materials and methods. The state of the blood antioxidant system was assessed by the activity of erythrocyte catalase and superoxide dismutase, the level of reduced thiol groups of erythrocytes, and the amperometric index of the total antioxidant activity of blood plasma. The activity of catalase was studied in the hemolysate of erythrocytes according to the method of Beers R.Results. It was established that there were significant changes in the functioning of individual links of the antioxidant protection system in patients with COPD and hypothyroidism, as well as the stress in the system in general. At the same time, enzyme activity of the antioxidant system of erythrocytes varies in multidirectional ways, whereas the indices of the cellular and extracellular non-enzyme links of the endogenous antioxidant system change in a unidirectional way towards the decrease, which may indicate a significant activation of free radical oxidation processes and partial depletion of the low-molecular antioxidant blood link.Conclusion. The revealed imbalance in the pro-/antioxidant system requires the introduction of drugs with antioxidant activity into therapeutic regimens. In patients with COPD, hypoxia and chronic inflammation may provoke oxidative stress, while in patients with hypothyroidism –decrease in the level of basal metabolism and anabolic processes in general. |
| first_indexed | 2024-03-07T21:48:44Z |
| format | Article |
| id | doaj.art-a6c3a464a82d44ddbf285016e52514e5 |
| institution | Directory Open Access Journal |
| issn | 1608-6228 2541-9544 |
| language | Russian |
| last_indexed | 2024-03-07T21:48:44Z |
| publishDate | 2017-11-01 |
| publisher | Ministry of Healthcare of the Russian Federation. “Kuban State Medical University” |
| record_format | Article |
| series | Кубанский научный медицинский вестник |
| spelling | doaj.art-a6c3a464a82d44ddbf285016e52514e52024-02-25T10:57:21ZrusMinistry of Healthcare of the Russian Federation. “Kuban State Medical University”Кубанский научный медицинский вестник1608-62282541-95442017-11-0105596210.25207/1608-6228-2017-24-5-59-62821COMPARATIVE ANALYSIS OF THE DYNAMICS OF IMMUNE-ANTIOXIDANT STATUS OF THE ANTIOXIDANT SYSTEM IN PATIENTS SUFFERING FROM HYPOTHYROIDISM AND COPDI. I. PAVLUCHENKO0E. I. DYDYSHKO1O. S. OKHREMENKO2Federal State Budgetary Educational Institution of Higher Education Kuban State Medical University of the Ministry of Healthcare of the Russian FederationFederal State Budgetary Educational Institution of Higher Education Kuban State Medical University of the Ministry of Healthcare of the Russian FederationFederal State Budgetary Educational Institution of Higher Education Kuban State Medical University of the Ministry of Healthcare of the Russian FederationAim. To carry out a comparative study of the features and shift tendency of individual indicators of the antioxidant system in patients with hypothyroidism and COPD of various phenotypes. 79 patients suffering from COPD III and IV were examined at the age of 60 to 80 years (men and women) who were hospitalized in the pulmonology department of the Regional Clinical Hospital No. 2 in Krasnodar, along with 47 patients suffering from hypothyroidism.Materials and methods. The state of the blood antioxidant system was assessed by the activity of erythrocyte catalase and superoxide dismutase, the level of reduced thiol groups of erythrocytes, and the amperometric index of the total antioxidant activity of blood plasma. The activity of catalase was studied in the hemolysate of erythrocytes according to the method of Beers R.Results. It was established that there were significant changes in the functioning of individual links of the antioxidant protection system in patients with COPD and hypothyroidism, as well as the stress in the system in general. At the same time, enzyme activity of the antioxidant system of erythrocytes varies in multidirectional ways, whereas the indices of the cellular and extracellular non-enzyme links of the endogenous antioxidant system change in a unidirectional way towards the decrease, which may indicate a significant activation of free radical oxidation processes and partial depletion of the low-molecular antioxidant blood link.Conclusion. The revealed imbalance in the pro-/antioxidant system requires the introduction of drugs with antioxidant activity into therapeutic regimens. In patients with COPD, hypoxia and chronic inflammation may provoke oxidative stress, while in patients with hypothyroidism –decrease in the level of basal metabolism and anabolic processes in general.https://ksma.elpub.ru/jour/article/view/881antioxidant protection, oxidative stresscopdhypothyroidismoxidant-antioxidant status |
| spellingShingle | I. I. PAVLUCHENKO E. I. DYDYSHKO O. S. OKHREMENKO COMPARATIVE ANALYSIS OF THE DYNAMICS OF IMMUNE-ANTIOXIDANT STATUS OF THE ANTIOXIDANT SYSTEM IN PATIENTS SUFFERING FROM HYPOTHYROIDISM AND COPD Кубанский научный медицинский вестник antioxidant protection, oxidative stress copd hypothyroidism oxidant-antioxidant status |
| title | COMPARATIVE ANALYSIS OF THE DYNAMICS OF IMMUNE-ANTIOXIDANT STATUS OF THE ANTIOXIDANT SYSTEM IN PATIENTS SUFFERING FROM HYPOTHYROIDISM AND COPD |
| title_full | COMPARATIVE ANALYSIS OF THE DYNAMICS OF IMMUNE-ANTIOXIDANT STATUS OF THE ANTIOXIDANT SYSTEM IN PATIENTS SUFFERING FROM HYPOTHYROIDISM AND COPD |
| title_fullStr | COMPARATIVE ANALYSIS OF THE DYNAMICS OF IMMUNE-ANTIOXIDANT STATUS OF THE ANTIOXIDANT SYSTEM IN PATIENTS SUFFERING FROM HYPOTHYROIDISM AND COPD |
| title_full_unstemmed | COMPARATIVE ANALYSIS OF THE DYNAMICS OF IMMUNE-ANTIOXIDANT STATUS OF THE ANTIOXIDANT SYSTEM IN PATIENTS SUFFERING FROM HYPOTHYROIDISM AND COPD |
| title_short | COMPARATIVE ANALYSIS OF THE DYNAMICS OF IMMUNE-ANTIOXIDANT STATUS OF THE ANTIOXIDANT SYSTEM IN PATIENTS SUFFERING FROM HYPOTHYROIDISM AND COPD |
| title_sort | comparative analysis of the dynamics of immune antioxidant status of the antioxidant system in patients suffering from hypothyroidism and copd |
| topic | antioxidant protection, oxidative stress copd hypothyroidism oxidant-antioxidant status |
| url | https://ksma.elpub.ru/jour/article/view/881 |
| work_keys_str_mv | AT iipavluchenko comparativeanalysisofthedynamicsofimmuneantioxidantstatusoftheantioxidantsysteminpatientssufferingfromhypothyroidismandcopd AT eidydyshko comparativeanalysisofthedynamicsofimmuneantioxidantstatusoftheantioxidantsysteminpatientssufferingfromhypothyroidismandcopd AT osokhremenko comparativeanalysisofthedynamicsofimmuneantioxidantstatusoftheantioxidantsysteminpatientssufferingfromhypothyroidismandcopd |