TCR Convergence in Individuals Treated With Immune Checkpoint Inhibition for Cancer

TCR Convergence in Individuals Treated With Immune Checkpoint Inhibition for Cancer

Tumor antigen-driven selection may expand T cells having T cell receptors (TCRs) of shared antigen specificity but different amino acid or nucleotide sequence in a process known as TCR convergence. Substitution sequencing errors introduced by TCRβ (TCRB) repertoire sequencing may create artifacts re...

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Bibliographic Details
Main Authors: Timothy John Looney, Denise Topacio-Hall, Geoffrey Lowman, Jeffrey Conroy, Carl Morrison, David Oh, Lawrence Fong, Li Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
biomarker
immune repertoire analysis
T cell repertoire
checkpoint blockade immunotherapy
convergence
AmpliSeq™
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02985/full

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