The study of the effects and side effects of methyldopa drug on changes in male rat kidney tissue
Introduction: Increased kidney disease in human societies is now one of the urologists concerns. Many of these kidney disorders can be caused by various drugs including blood pressure lowering drugs.Methods: In this experimental study, 40 male wistar rats were used. The rats were divided into 4 grou...
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| Format: | Article |
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Qom Islamic Azad University
2016-08-01
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| Series: | بیولوژی کاربردی |
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| Online Access: | https://sjoapb.qom.iau.ir/article_523580_ae1463491e834c337ed1ff8ea70f16f8.pdf |
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| author | Mehdi Ahmadifar سید مهدی کلانتر ناصر کلهر سپیده جعفرزاده راستین فاطمه تقوایی مهدی لطفی پناه |
| author_facet | Mehdi Ahmadifar سید مهدی کلانتر ناصر کلهر سپیده جعفرزاده راستین فاطمه تقوایی مهدی لطفی پناه |
| author_sort | Mehdi Ahmadifar |
| collection | DOAJ |
| description | Introduction: Increased kidney disease in human societies is now one of the urologists concerns. Many of these kidney disorders can be caused by various drugs including blood pressure lowering drugs.Methods: In this experimental study, 40 male wistar rats were used. The rats were divided into 4 groups of 10 including control, first, second and third experimental groups which received respectively water, 0.03, 0.06 and 0.08 mg/ kg methyldopa drug via gavage. After 1 month, these40 mice were anesthetized and their kidneys were removed.After preparing microscopic sections, they were stained using H & E staining and stained samples were observed with a light microscope. Then images of desired samples were prepared using a light microscope equipped with camera.Results: the obtained results shows that the consumption of high doses methyldopa drugs lead to disturbance in kidney function and related enzymatic processes. Moreover it can cause remarkable changes in different kidney layers.Conclusion:regarding obtained results, prescribing methyldopa drug should be done more carefully. |
| first_indexed | 2024-03-12T23:13:41Z |
| format | Article |
| id | doaj.art-a6c5d202d0bc4e629c33ef2cfd9f9a3a |
| institution | Directory Open Access Journal |
| issn | 2538-3434 |
| language | fas |
| last_indexed | 2024-03-12T23:13:41Z |
| publishDate | 2016-08-01 |
| publisher | Qom Islamic Azad University |
| record_format | Article |
| series | بیولوژی کاربردی |
| spelling | doaj.art-a6c5d202d0bc4e629c33ef2cfd9f9a3a2023-07-17T15:00:51ZfasQom Islamic Azad Universityبیولوژی کاربردی2538-34342016-08-01622913523580The study of the effects and side effects of methyldopa drug on changes in male rat kidney tissueMehdi Ahmadifar0سید مهدی کلانتر1ناصر کلهر2سپیده جعفرزاده راستین3فاطمه تقوایی4مهدی لطفی پناه5Royan Instituteهیئت علمیمدرس دانشگاه آزاد قمدانشجو/ دانشگاه شهید صدوقی یزددانشجو/ دانشگاه شهید صدوقی یزدپژوهشگر/ پژوهشگاه رویانIntroduction: Increased kidney disease in human societies is now one of the urologists concerns. Many of these kidney disorders can be caused by various drugs including blood pressure lowering drugs.Methods: In this experimental study, 40 male wistar rats were used. The rats were divided into 4 groups of 10 including control, first, second and third experimental groups which received respectively water, 0.03, 0.06 and 0.08 mg/ kg methyldopa drug via gavage. After 1 month, these40 mice were anesthetized and their kidneys were removed.After preparing microscopic sections, they were stained using H & E staining and stained samples were observed with a light microscope. Then images of desired samples were prepared using a light microscope equipped with camera.Results: the obtained results shows that the consumption of high doses methyldopa drugs lead to disturbance in kidney function and related enzymatic processes. Moreover it can cause remarkable changes in different kidney layers.Conclusion:regarding obtained results, prescribing methyldopa drug should be done more carefully.https://sjoapb.qom.iau.ir/article_523580_ae1463491e834c337ed1ff8ea70f16f8.pdfmethyldopakidney tissueblood pressurerat |
| spellingShingle | Mehdi Ahmadifar سید مهدی کلانتر ناصر کلهر سپیده جعفرزاده راستین فاطمه تقوایی مهدی لطفی پناه The study of the effects and side effects of methyldopa drug on changes in male rat kidney tissue بیولوژی کاربردی methyldopa kidney tissue blood pressure rat |
| title | The study of the effects and side effects of methyldopa drug on changes in male rat kidney tissue |
| title_full | The study of the effects and side effects of methyldopa drug on changes in male rat kidney tissue |
| title_fullStr | The study of the effects and side effects of methyldopa drug on changes in male rat kidney tissue |
| title_full_unstemmed | The study of the effects and side effects of methyldopa drug on changes in male rat kidney tissue |
| title_short | The study of the effects and side effects of methyldopa drug on changes in male rat kidney tissue |
| title_sort | study of the effects and side effects of methyldopa drug on changes in male rat kidney tissue |
| topic | methyldopa kidney tissue blood pressure rat |
| url | https://sjoapb.qom.iau.ir/article_523580_ae1463491e834c337ed1ff8ea70f16f8.pdf |
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