Identification of Putative Plant-Based ALR-2 Inhibitors to Treat Diabetic Peripheral Neuropathy

Identification of Putative Plant-Based ALR-2 Inhibitors to Treat Diabetic Peripheral Neuropathy

Diabetic peripheral neuropathy (DPN) is a common diabetes complication (DM). Aldose reductase -2 (ALR-2) is an oxidoreductase enzyme that is most extensively studied therapeutic target for diabetes-related complications that can be inhibited by epalrestat, which has severe adverse effects; hence the...

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Main Authors: Mohd Saeed, Munazzah Tasleem, Ambreen Shoib, Mohd Adnan Kausar, Abdel Moneim E. Sulieman, Nadiyah M. Alabdallah, Zeina El Asmar, Abdelmuhsin Abdelgadir, Asma Al-Shammary, Md Jahoor Alam, Riadh Badroui, Maryam Zahin
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Current Issues in Molecular Biology
Subjects:
pharmacophore
structure-based drug design
NuBBE<sub>DB</sub>
ADMET
molecular docking
Online Access:https://www.mdpi.com/1467-3045/44/7/194

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