Rapid, label‐free enrichment of lymphocytes in a closed system using a flow‐through microfluidic device

Rapid, label‐free enrichment of lymphocytes in a closed system using a flow‐through microfluidic device

Abstract The majority of adoptive cellular therapies are produced from peripheral mononuclear cells obtained via leukapheresis and further enriched for the cells of interest (e.g., T cells). Here, we present a first‐of‐its‐kind closed system, which effectively removes ~85% of monocytes and ~88% of p...

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Bibliographic Details
Main Authors: Anton Mukhamedshin, Riley C. Reddington, Mai T. P. Dinh, Kumar Abhishek, Mubasher Iqbal, Marc Manheim, Sean C. Gifford, Sergey S. Shevkoplyas
Format: Article
Language:English
Published: Wiley 2024-01-01
Series:Bioengineering & Translational Medicine
Subjects:
cell separation
cellular therapy
leukapheresis
lymphocytes
microfluidics
Online Access:https://doi.org/10.1002/btm2.10602

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