Cognitive functions and epilepsy-related characteristics in patients with generalized tonic–clonic epilepsy: a cross-sectional study
Abstract Background Epilepsy is a brain disorder affecting nearly 65 million people worldwide. It is characterized by sudden, transient, and uncontrolled episodes of brain dysfunction secondary to hypersynchronous abnormal discharge of cortical neuronal cells resulting in motor, sensory, and behavio...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-02-01
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| Series: | Middle East Current Psychiatry |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43045-023-00293-6 |
| _version_ | 1811171899969896448 |
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| author | Nesma Mohamed Sayed Magda Taha Kamal Aldin Samir Elshamly Ali Ahmed Elarabi Hendi |
| author_facet | Nesma Mohamed Sayed Magda Taha Kamal Aldin Samir Elshamly Ali Ahmed Elarabi Hendi |
| author_sort | Nesma Mohamed Sayed |
| collection | DOAJ |
| description | Abstract Background Epilepsy is a brain disorder affecting nearly 65 million people worldwide. It is characterized by sudden, transient, and uncontrolled episodes of brain dysfunction secondary to hypersynchronous abnormal discharge of cortical neuronal cells resulting in motor, sensory, and behavioral manifestations. Cognitive deterioration can occur in approximately 70–80% of epileptic patients with a variety of epilepsy-related characteristics being implicated. This study aimed to assess cognitive functions in a sample of patients with generalized tonic–clonic epilepsy and determine its relation to different epilepsy-related characteristics. It was designed as a case–control cross-sectional study in which 106 participants were enrolled and divided into two groups: a case group of fifty-three patients diagnosed with generalized tonic–clonic epilepsy and a control group including fifty-three healthy subjects. Sociodemographic and epilepsy-related characteristics and a variety of cognitive functions were assessed for both groups. Results Epileptic patients were significantly suffering from impairment in attention, memory, visuospatial (P = 0.001), and language functions (P = 0.018) compared to the healthy control group. Conclusions Epileptic patients are significantly suffering from cognitive impairment with a variety of contributing epilepsy-related characteristics. |
| first_indexed | 2024-04-10T17:21:53Z |
| format | Article |
| id | doaj.art-a6cb479d86ae4f328854d56b66879ce0 |
| institution | Directory Open Access Journal |
| issn | 2090-5416 |
| language | English |
| last_indexed | 2024-04-10T17:21:53Z |
| publishDate | 2023-02-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Middle East Current Psychiatry |
| spelling | doaj.art-a6cb479d86ae4f328854d56b66879ce02023-02-05T12:03:36ZengSpringerOpenMiddle East Current Psychiatry2090-54162023-02-013011610.1186/s43045-023-00293-6Cognitive functions and epilepsy-related characteristics in patients with generalized tonic–clonic epilepsy: a cross-sectional studyNesma Mohamed Sayed0Magda Taha Kamal Aldin1Samir Elshamly Ali2Ahmed Elarabi Hendi3Department of Psychiatry and Neurology, Faculty of Medicine, Suez Canal UniversityDepartment of Psychiatry and Neurology, Faculty of Medicine, Suez Canal UniversityDepartment of Psychiatry and Neurology, Faculty of Medicine, Suez Canal UniversityDepartment of Psychiatry and Neurology, Faculty of Medicine, Suez Canal UniversityAbstract Background Epilepsy is a brain disorder affecting nearly 65 million people worldwide. It is characterized by sudden, transient, and uncontrolled episodes of brain dysfunction secondary to hypersynchronous abnormal discharge of cortical neuronal cells resulting in motor, sensory, and behavioral manifestations. Cognitive deterioration can occur in approximately 70–80% of epileptic patients with a variety of epilepsy-related characteristics being implicated. This study aimed to assess cognitive functions in a sample of patients with generalized tonic–clonic epilepsy and determine its relation to different epilepsy-related characteristics. It was designed as a case–control cross-sectional study in which 106 participants were enrolled and divided into two groups: a case group of fifty-three patients diagnosed with generalized tonic–clonic epilepsy and a control group including fifty-three healthy subjects. Sociodemographic and epilepsy-related characteristics and a variety of cognitive functions were assessed for both groups. Results Epileptic patients were significantly suffering from impairment in attention, memory, visuospatial (P = 0.001), and language functions (P = 0.018) compared to the healthy control group. Conclusions Epileptic patients are significantly suffering from cognitive impairment with a variety of contributing epilepsy-related characteristics.https://doi.org/10.1186/s43045-023-00293-6EpilepsyCognitive functionsEpilepsy-related characteristics |
| spellingShingle | Nesma Mohamed Sayed Magda Taha Kamal Aldin Samir Elshamly Ali Ahmed Elarabi Hendi Cognitive functions and epilepsy-related characteristics in patients with generalized tonic–clonic epilepsy: a cross-sectional study Middle East Current Psychiatry Epilepsy Cognitive functions Epilepsy-related characteristics |
| title | Cognitive functions and epilepsy-related characteristics in patients with generalized tonic–clonic epilepsy: a cross-sectional study |
| title_full | Cognitive functions and epilepsy-related characteristics in patients with generalized tonic–clonic epilepsy: a cross-sectional study |
| title_fullStr | Cognitive functions and epilepsy-related characteristics in patients with generalized tonic–clonic epilepsy: a cross-sectional study |
| title_full_unstemmed | Cognitive functions and epilepsy-related characteristics in patients with generalized tonic–clonic epilepsy: a cross-sectional study |
| title_short | Cognitive functions and epilepsy-related characteristics in patients with generalized tonic–clonic epilepsy: a cross-sectional study |
| title_sort | cognitive functions and epilepsy related characteristics in patients with generalized tonic clonic epilepsy a cross sectional study |
| topic | Epilepsy Cognitive functions Epilepsy-related characteristics |
| url | https://doi.org/10.1186/s43045-023-00293-6 |
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