MLK4 regulates DNA damage response and promotes triple-negative breast cancer chemoresistance

MLK4 regulates DNA damage response and promotes triple-negative breast cancer chemoresistance

Abstract Chemoresistance constitutes a major challenge in the treatment of triple-negative breast cancer (TNBC). Mixed-Lineage Kinase 4 (MLK4) is frequently amplified or overexpressed in TNBC where it facilitates the aggressive growth and migratory potential of breast cancer cells. However, the func...

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Bibliographic Details
Main Authors: Dawid Mehlich, Michał Łomiak, Aleksandra Sobiborowicz, Alicja Mazan, Dagmara Dymerska, Łukasz M. Szewczyk, Anna Mehlich, Agnieszka Borowiec, Monika K. Prełowska, Adam Gorczyński, Paweł Jabłoński, Ewa Iżycka-Świeszewska, Dominika Nowis, Anna A. Marusiak
Format: Article
Language:English
Published: Nature Publishing Group 2021-11-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-04405-0

Internet

https://doi.org/10.1038/s41419-021-04405-0

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