Application of proanthocyanidin in the treatment and repair of deep caries
Proanthocyanidin (PA), as a kind of natural plant polyphenol, have a variety of biological functions, such as promoting remineralization, inducing collagen cross-linking, inhibiting protease activity and inhibiting bacteria. Therefore, PA could be broadly used in the clinical application of treatmen...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases
2023-07-01
|
| Series: | 口腔疾病防治 |
| Subjects: | |
| Online Access: | https://www.kqjbfz.com/CN/10.12016/j.issn.2096-1456.2023.07.010 |
| _version_ | 1797859638718234624 |
|---|---|
| author | GAO Ying WANG Jue TAO Lu YAO Jingjing YU Jinling HUANG Handan YANG Liuqing LIU Zhihui |
| author_facet | GAO Ying WANG Jue TAO Lu YAO Jingjing YU Jinling HUANG Handan YANG Liuqing LIU Zhihui |
| author_sort | GAO Ying |
| collection | DOAJ |
| description | Proanthocyanidin (PA), as a kind of natural plant polyphenol, have a variety of biological functions, such as promoting remineralization, inducing collagen cross-linking, inhibiting protease activity and inhibiting bacteria. Therefore, PA could be broadly used in the clinical application of treatment and repair of deep caries in the future; for example, PA could promote dentin remineralization, improve resin-dentin bonding durability and improve the dentin acid erosion effect. This application potential of PA arises from several features, firstly, PA can not only promote dentin remineralization on its own or with other remineralizers but also exhibits antibacterial effects, which can inhibit acid production while reducing the formation of cariogenic pathogens and their biofilms. Based on the above features, PA can reduce the incidence of caries disease; thus, PA improves deep caries and long-term effects after treatment. In addition, PA added to adhesives or etch agents can improve the etching and bonding effect of dentin by inducing collagen cross-linking and inhibiting protease activity, thus achieving the ultimate goal of improving the bonding performance of deep caries. This paper summarizes recent progress of research on PA for the treatment and repair of deep caries, including the promotion of dentin remineralization and antibacterial activity as well as the improvement in dentin bonding and acid etching effect, to provide a more comprehensive reference for treating and restoring deep caries in clinical practice. |
| first_indexed | 2024-04-09T21:32:49Z |
| format | Article |
| id | doaj.art-a6ccc0c884714db395054ee6e7a43b19 |
| institution | Directory Open Access Journal |
| issn | 2096-1456 |
| language | zho |
| last_indexed | 2024-04-09T21:32:49Z |
| publishDate | 2023-07-01 |
| publisher | Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases |
| record_format | Article |
| series | 口腔疾病防治 |
| spelling | doaj.art-a6ccc0c884714db395054ee6e7a43b192023-03-27T07:36:27ZzhoEditorial Department of Journal of Prevention and Treatment for Stomatological Diseases口腔疾病防治2096-14562023-07-0131751852310.12016/j.issn.2096⁃1456.2023.07.010Application of proanthocyanidin in the treatment and repair of deep cariesGAO Ying0WANG Jue1 TAO Lu2 YAO Jingjing3 YU Jinling 4 HUANG Handan5YANG Liuqing6 LIU Zhihui 7Department of Prosthodontics, Hospital of Stomatology, Jilin UniversityDepartment of Prosthodontics, Hospital of Stomatology, Jilin UniversityDepartment of Prosthodontics, Hospital of Stomatology, Jilin UniversityDepartment of Prosthodontics, Hospital of Stomatology, Jilin UniversityDepartment of Prosthodontics, Hospital of Stomatology, Jilin UniversityDepartment of Prosthodontics, Hospital of Stomatology, Jilin UniversityDepartment of Prosthodontics, Hospital of Stomatology, Jilin UniversityDepartment of Prosthodontics, Hospital of Stomatology, Jilin UniversityProanthocyanidin (PA), as a kind of natural plant polyphenol, have a variety of biological functions, such as promoting remineralization, inducing collagen cross-linking, inhibiting protease activity and inhibiting bacteria. Therefore, PA could be broadly used in the clinical application of treatment and repair of deep caries in the future; for example, PA could promote dentin remineralization, improve resin-dentin bonding durability and improve the dentin acid erosion effect. This application potential of PA arises from several features, firstly, PA can not only promote dentin remineralization on its own or with other remineralizers but also exhibits antibacterial effects, which can inhibit acid production while reducing the formation of cariogenic pathogens and their biofilms. Based on the above features, PA can reduce the incidence of caries disease; thus, PA improves deep caries and long-term effects after treatment. In addition, PA added to adhesives or etch agents can improve the etching and bonding effect of dentin by inducing collagen cross-linking and inhibiting protease activity, thus achieving the ultimate goal of improving the bonding performance of deep caries. This paper summarizes recent progress of research on PA for the treatment and repair of deep caries, including the promotion of dentin remineralization and antibacterial activity as well as the improvement in dentin bonding and acid etching effect, to provide a more comprehensive reference for treating and restoring deep caries in clinical practice.https://www.kqjbfz.com/CN/10.12016/j.issn.2096-1456.2023.07.010proanthocyanidintooth remineralizationdentin-bonding agentsdental cariescollagenacid etchingcross-linking reagentsmatrix metalloproteinases |
| spellingShingle | GAO Ying WANG Jue TAO Lu YAO Jingjing YU Jinling HUANG Handan YANG Liuqing LIU Zhihui Application of proanthocyanidin in the treatment and repair of deep caries 口腔疾病防治 proanthocyanidin tooth remineralization dentin-bonding agents dental caries collagen acid etching cross-linking reagents matrix metalloproteinases |
| title | Application of proanthocyanidin in the treatment and repair of deep caries |
| title_full | Application of proanthocyanidin in the treatment and repair of deep caries |
| title_fullStr | Application of proanthocyanidin in the treatment and repair of deep caries |
| title_full_unstemmed | Application of proanthocyanidin in the treatment and repair of deep caries |
| title_short | Application of proanthocyanidin in the treatment and repair of deep caries |
| title_sort | application of proanthocyanidin in the treatment and repair of deep caries |
| topic | proanthocyanidin tooth remineralization dentin-bonding agents dental caries collagen acid etching cross-linking reagents matrix metalloproteinases |
| url | https://www.kqjbfz.com/CN/10.12016/j.issn.2096-1456.2023.07.010 |
| work_keys_str_mv | AT gaoying applicationofproanthocyanidininthetreatmentandrepairofdeepcaries AT wangjue applicationofproanthocyanidininthetreatmentandrepairofdeepcaries AT taolu applicationofproanthocyanidininthetreatmentandrepairofdeepcaries AT yaojingjing applicationofproanthocyanidininthetreatmentandrepairofdeepcaries AT yujinling applicationofproanthocyanidininthetreatmentandrepairofdeepcaries AT huanghandan applicationofproanthocyanidininthetreatmentandrepairofdeepcaries AT yangliuqing applicationofproanthocyanidininthetreatmentandrepairofdeepcaries AT liuzhihui applicationofproanthocyanidininthetreatmentandrepairofdeepcaries |