Phages and Their Role in Gastrointestinal Disease: Focus on Inflammatory Bowel Disease
Inflammatory bowel diseases (IBDs) are a group of chronic autoinflammatory diseases including Crohn’s disease and ulcerative colitis. Although the molecular mechanisms governing the pathogenesis of gastrointestinal inflammation are not completely clear, the main factors are presumed to be genetic pr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/4/1013 |
| _version_ | 1797570266138673152 |
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| author | Martin Maronek Rene Link Lubos Ambro Roman Gardlik |
| author_facet | Martin Maronek Rene Link Lubos Ambro Roman Gardlik |
| author_sort | Martin Maronek |
| collection | DOAJ |
| description | Inflammatory bowel diseases (IBDs) are a group of chronic autoinflammatory diseases including Crohn’s disease and ulcerative colitis. Although the molecular mechanisms governing the pathogenesis of gastrointestinal inflammation are not completely clear, the main factors are presumed to be genetic predisposition, environmental exposure, and the intestinal microbiome. Hitherto, most of the studies focusing on the role of the microbiome studied the action and effect of bacteria. However, the intestinal microbiome comprises other members of the microbial community as well, namely, fungi, protozoa, and viruses. We believe that bacteriophages are among the main orchestrators of the effect of microbiota on the gut mucosa. Therefore, this review aims to summarize the knowledge of the role of intestinal phageome in IBD and to discuss the concept of phage therapy and its future applications. |
| first_indexed | 2024-03-10T20:23:28Z |
| format | Article |
| id | doaj.art-a6cdb2bb80854003a00b72cd85929e09 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T20:23:28Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-a6cdb2bb80854003a00b72cd85929e092023-11-19T22:02:21ZengMDPI AGCells2073-44092020-04-0194101310.3390/cells9041013Phages and Their Role in Gastrointestinal Disease: Focus on Inflammatory Bowel DiseaseMartin Maronek0Rene Link1Lubos Ambro2Roman Gardlik3Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, 811 08 Bratislava, SlovakiaInstitute of Experimental Medicine, Faculty of Medicine, University of Pavol Jozef Šafárik, 040 11 Košice, SlovakiaInstitute of Experimental Medicine, Faculty of Medicine, University of Pavol Jozef Šafárik, 040 11 Košice, SlovakiaInstitute of Molecular Biomedicine, Faculty of Medicine, Comenius University, 811 08 Bratislava, SlovakiaInflammatory bowel diseases (IBDs) are a group of chronic autoinflammatory diseases including Crohn’s disease and ulcerative colitis. Although the molecular mechanisms governing the pathogenesis of gastrointestinal inflammation are not completely clear, the main factors are presumed to be genetic predisposition, environmental exposure, and the intestinal microbiome. Hitherto, most of the studies focusing on the role of the microbiome studied the action and effect of bacteria. However, the intestinal microbiome comprises other members of the microbial community as well, namely, fungi, protozoa, and viruses. We believe that bacteriophages are among the main orchestrators of the effect of microbiota on the gut mucosa. Therefore, this review aims to summarize the knowledge of the role of intestinal phageome in IBD and to discuss the concept of phage therapy and its future applications.https://www.mdpi.com/2073-4409/9/4/1013viromephageomeinflammatory bowel diseaseintestinal inflammationphage therapy |
| spellingShingle | Martin Maronek Rene Link Lubos Ambro Roman Gardlik Phages and Their Role in Gastrointestinal Disease: Focus on Inflammatory Bowel Disease Cells virome phageome inflammatory bowel disease intestinal inflammation phage therapy |
| title | Phages and Their Role in Gastrointestinal Disease: Focus on Inflammatory Bowel Disease |
| title_full | Phages and Their Role in Gastrointestinal Disease: Focus on Inflammatory Bowel Disease |
| title_fullStr | Phages and Their Role in Gastrointestinal Disease: Focus on Inflammatory Bowel Disease |
| title_full_unstemmed | Phages and Their Role in Gastrointestinal Disease: Focus on Inflammatory Bowel Disease |
| title_short | Phages and Their Role in Gastrointestinal Disease: Focus on Inflammatory Bowel Disease |
| title_sort | phages and their role in gastrointestinal disease focus on inflammatory bowel disease |
| topic | virome phageome inflammatory bowel disease intestinal inflammation phage therapy |
| url | https://www.mdpi.com/2073-4409/9/4/1013 |
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