Negative Impact of Wound Complications on Oncologic Outcome of Soft Tissue Sarcomas of the Chest Wall
A link of complications with worse oncologic prognosis has been established for multiple malignancies, while the limited literature on soft-tissue sarcomas is inconclusive. The aim of this study was to examine risk factors and the oncologic impact of wound complications after curative resection of p...
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| Format: | Article |
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MDPI AG
2019-12-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/12/1/101 |
| _version_ | 1797725286367756288 |
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| author | Mehran Dadras Pascal Koepp Johannes Maximilian Wagner Christoph Wallner Maxi Sacher Marcus Lehnhardt Björn Behr Kamran Harati |
| author_facet | Mehran Dadras Pascal Koepp Johannes Maximilian Wagner Christoph Wallner Maxi Sacher Marcus Lehnhardt Björn Behr Kamran Harati |
| author_sort | Mehran Dadras |
| collection | DOAJ |
| description | A link of complications with worse oncologic prognosis has been established for multiple malignancies, while the limited literature on soft-tissue sarcomas is inconclusive. The aim of this study was to examine risk factors and the oncologic impact of wound complications after curative resection of primary soft-tissue sarcomas of the chest wall. Patients with primary soft tissue sarcomas of the chest wall were identified. Groups with and without wound complications were compared by using univariate and multivariate analysis to identify risk factors. For patients with clear surgical margins (R0), univariate and multivariate analysis of factors associated with 5-year local recurrence free survival (LRFS), metastasis free survival (MFS), and disease specific survival (DSS) were performed. A total of 102 patients were included in the study. Wound complications occurred in 11 patients (10.8%) within 90 days. Cardiovascular morbidity and operation time represented independent risk factors for wound complications. In 94 patients with clear surgical margins, those with wound complications had an estimated 5-year LRFS of 30% versus 72.6% and a 5-year DSS of 58.3% versus 82.1%. Wound complications could be identified as an independent predictor for worse LRFS and DSS. Patients with a high risk of wound complications should be identified and strategies implemented to reduce surgical complications and possibly improve oncologic prognosis. |
| first_indexed | 2024-03-12T10:28:59Z |
| format | Article |
| id | doaj.art-a6cdcd04bc354362991680d73af36616 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T10:28:59Z |
| publishDate | 2019-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-a6cdcd04bc354362991680d73af366162023-09-02T09:28:36ZengMDPI AGCancers2072-66942019-12-0112110110.3390/cancers12010101cancers12010101Negative Impact of Wound Complications on Oncologic Outcome of Soft Tissue Sarcomas of the Chest WallMehran Dadras0Pascal Koepp1Johannes Maximilian Wagner2Christoph Wallner3Maxi Sacher4Marcus Lehnhardt5Björn Behr6Kamran Harati7Department of Plastic Surgery, BG University Hospital Bergmannsheil, 44787 Bochum, GermanyDepartment of Plastic Surgery, BG University Hospital Bergmannsheil, 44787 Bochum, GermanyDepartment of Plastic Surgery, BG University Hospital Bergmannsheil, 44787 Bochum, GermanyDepartment of Plastic Surgery, BG University Hospital Bergmannsheil, 44787 Bochum, GermanyDepartment of Plastic Surgery, BG University Hospital Bergmannsheil, 44787 Bochum, GermanyDepartment of Plastic Surgery, BG University Hospital Bergmannsheil, 44787 Bochum, GermanyDepartment of Plastic Surgery, BG University Hospital Bergmannsheil, 44787 Bochum, GermanyDepartment of Plastic Surgery, BG University Hospital Bergmannsheil, 44787 Bochum, GermanyA link of complications with worse oncologic prognosis has been established for multiple malignancies, while the limited literature on soft-tissue sarcomas is inconclusive. The aim of this study was to examine risk factors and the oncologic impact of wound complications after curative resection of primary soft-tissue sarcomas of the chest wall. Patients with primary soft tissue sarcomas of the chest wall were identified. Groups with and without wound complications were compared by using univariate and multivariate analysis to identify risk factors. For patients with clear surgical margins (R0), univariate and multivariate analysis of factors associated with 5-year local recurrence free survival (LRFS), metastasis free survival (MFS), and disease specific survival (DSS) were performed. A total of 102 patients were included in the study. Wound complications occurred in 11 patients (10.8%) within 90 days. Cardiovascular morbidity and operation time represented independent risk factors for wound complications. In 94 patients with clear surgical margins, those with wound complications had an estimated 5-year LRFS of 30% versus 72.6% and a 5-year DSS of 58.3% versus 82.1%. Wound complications could be identified as an independent predictor for worse LRFS and DSS. Patients with a high risk of wound complications should be identified and strategies implemented to reduce surgical complications and possibly improve oncologic prognosis.https://www.mdpi.com/2072-6694/12/1/101soft tissue sarcomawound complicationstumorchest wall |
| spellingShingle | Mehran Dadras Pascal Koepp Johannes Maximilian Wagner Christoph Wallner Maxi Sacher Marcus Lehnhardt Björn Behr Kamran Harati Negative Impact of Wound Complications on Oncologic Outcome of Soft Tissue Sarcomas of the Chest Wall Cancers soft tissue sarcoma wound complications tumor chest wall |
| title | Negative Impact of Wound Complications on Oncologic Outcome of Soft Tissue Sarcomas of the Chest Wall |
| title_full | Negative Impact of Wound Complications on Oncologic Outcome of Soft Tissue Sarcomas of the Chest Wall |
| title_fullStr | Negative Impact of Wound Complications on Oncologic Outcome of Soft Tissue Sarcomas of the Chest Wall |
| title_full_unstemmed | Negative Impact of Wound Complications on Oncologic Outcome of Soft Tissue Sarcomas of the Chest Wall |
| title_short | Negative Impact of Wound Complications on Oncologic Outcome of Soft Tissue Sarcomas of the Chest Wall |
| title_sort | negative impact of wound complications on oncologic outcome of soft tissue sarcomas of the chest wall |
| topic | soft tissue sarcoma wound complications tumor chest wall |
| url | https://www.mdpi.com/2072-6694/12/1/101 |
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