Appraising the use of tranexamic acid in traumatic and non‐traumatic intracranial hemorrhage: A narrative review
Abstract Recently there has been increasing interest and debate on the use of tranexamic acid (TXA), an antifibrinolytic drug, in both traumatic and non‐traumatic intracranial hemorrhage. In this review we aim to discuss recent investigations looking at TXA in traumatic brain injury (TBI) and differ...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-08-01
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| Series: | Journal of the American College of Emergency Physicians Open |
| Online Access: | https://doi.org/10.1002/emp2.12777 |
| _version_ | 1811282835715129344 |
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| author | Nicholas D. Jakowenko Brian J. Kopp Brian L. Erstad |
| author_facet | Nicholas D. Jakowenko Brian J. Kopp Brian L. Erstad |
| author_sort | Nicholas D. Jakowenko |
| collection | DOAJ |
| description | Abstract Recently there has been increasing interest and debate on the use of tranexamic acid (TXA), an antifibrinolytic drug, in both traumatic and non‐traumatic intracranial hemorrhage. In this review we aim to discuss recent investigations looking at TXA in traumatic brain injury (TBI) and different categories of spontaneous intracranial hemorrhage. We also discuss differences between setting (hospital vs pre‐hospital), dosing and timing strategies, and other logistical challenges surrounding optimal use of TXA for isolated intracranial hemorrhage. Last, we hope to provide guidance for clinicians when considering the use of TXA in a patient with traumatic or non‐traumatic intracranial hemorrhage based on appraisal of the available literature as well as some potential ideas for future research in this area. |
| first_indexed | 2024-04-13T01:59:41Z |
| format | Article |
| id | doaj.art-a6cf084a76954717917a5634f0fec0c2 |
| institution | Directory Open Access Journal |
| issn | 2688-1152 |
| language | English |
| last_indexed | 2024-04-13T01:59:41Z |
| publishDate | 2022-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American College of Emergency Physicians Open |
| spelling | doaj.art-a6cf084a76954717917a5634f0fec0c22022-12-22T03:07:40ZengWileyJournal of the American College of Emergency Physicians Open2688-11522022-08-0134n/an/a10.1002/emp2.12777Appraising the use of tranexamic acid in traumatic and non‐traumatic intracranial hemorrhage: A narrative reviewNicholas D. Jakowenko0Brian J. Kopp1Brian L. Erstad2Department of Pharmacy Mayo Clinic Rochester Minnesota USADepartment of Pharmacy Banner University Medical Center–Tucson Tucson Arizona USADepartment of Pharmacy Practice and Science University of Arizona College of Pharmacy Tucson Arizona USAAbstract Recently there has been increasing interest and debate on the use of tranexamic acid (TXA), an antifibrinolytic drug, in both traumatic and non‐traumatic intracranial hemorrhage. In this review we aim to discuss recent investigations looking at TXA in traumatic brain injury (TBI) and different categories of spontaneous intracranial hemorrhage. We also discuss differences between setting (hospital vs pre‐hospital), dosing and timing strategies, and other logistical challenges surrounding optimal use of TXA for isolated intracranial hemorrhage. Last, we hope to provide guidance for clinicians when considering the use of TXA in a patient with traumatic or non‐traumatic intracranial hemorrhage based on appraisal of the available literature as well as some potential ideas for future research in this area.https://doi.org/10.1002/emp2.12777 |
| spellingShingle | Nicholas D. Jakowenko Brian J. Kopp Brian L. Erstad Appraising the use of tranexamic acid in traumatic and non‐traumatic intracranial hemorrhage: A narrative review Journal of the American College of Emergency Physicians Open |
| title | Appraising the use of tranexamic acid in traumatic and non‐traumatic intracranial hemorrhage: A narrative review |
| title_full | Appraising the use of tranexamic acid in traumatic and non‐traumatic intracranial hemorrhage: A narrative review |
| title_fullStr | Appraising the use of tranexamic acid in traumatic and non‐traumatic intracranial hemorrhage: A narrative review |
| title_full_unstemmed | Appraising the use of tranexamic acid in traumatic and non‐traumatic intracranial hemorrhage: A narrative review |
| title_short | Appraising the use of tranexamic acid in traumatic and non‐traumatic intracranial hemorrhage: A narrative review |
| title_sort | appraising the use of tranexamic acid in traumatic and non traumatic intracranial hemorrhage a narrative review |
| url | https://doi.org/10.1002/emp2.12777 |
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