Utilisation of real-world data from heart failure registries in OECD countries - A systematic review

Background: Heart failure represents a major public health issue that impacts 26 million people globally. Currently, real-world data represents a key instrument for providing the verification of both internal and external validity, yet there is still a lack of understanding regarding its scope in co...

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Main Authors: Xiaoyang Du, Adina Khamitova, Mattias Kyhlstedt, Sun Sun, Mathilde Sengoelge
Format: Article
Language:English
Published: Elsevier 2018-06-01
Series:International Journal of Cardiology: Heart & Vasculature
Online Access:http://www.sciencedirect.com/science/article/pii/S2352906718300149
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author Xiaoyang Du
Adina Khamitova
Mattias Kyhlstedt
Sun Sun
Mathilde Sengoelge
author_facet Xiaoyang Du
Adina Khamitova
Mattias Kyhlstedt
Sun Sun
Mathilde Sengoelge
author_sort Xiaoyang Du
collection DOAJ
description Background: Heart failure represents a major public health issue that impacts 26 million people globally. Currently, real-world data represents a key instrument for providing the verification of both internal and external validity, yet there is still a lack of understanding regarding its scope in complementing evidence of treatments for heart failure. This study aims to increase understanding of the utilisation of real-word data from heart failure registries in Organisation for Economic Co-operation and Development (OECD) countries. Method: This was a systematic review of existing observational studies from heart failure registries in 35 OECD member countries. Studies from 2000 to March 2017 were identified through electronic databases (MEDLINE (Ovid), EMBASE, Web of Science Core Collection, CINAHL (Ebsco), Cochrane CENTRAL) and appraised according to eligibility criteria. Results: Two-hundred and two studies met the inclusion criteria, in which the majority were published from 2013 to 2016. All 202 studies were observational, among which 98% were cohort studies (198). The median sample size of all studies was 5152 (2417 to 32,890) and median study period 55 months (33.0 to 72.0). Swedish heart failure registry had the most publications (24, 12%). Conclusion: Since 2000 there has been an upward trend in the number of published observational studies on heart failure registries in OECD countries with increasingly diverse outcomes and advanced statistical methods to improve their validity and reliability. This indicates that the utilisation of real-world data has experienced a significant upsurge in complementing the findings of clinical trials for improved research of heart failure treatments. Keywords: Systematic review, Heart failure, Registry, Real-world data, Observational study, OECD
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spelling doaj.art-a6d493dc892f4465bf785333924b60052022-12-22T01:08:47ZengElsevierInternational Journal of Cardiology: Heart & Vasculature2352-90672018-06-01199097Utilisation of real-world data from heart failure registries in OECD countries - A systematic reviewXiaoyang Du0Adina Khamitova1Mattias Kyhlstedt2Sun Sun3Mathilde Sengoelge4Department of Learning, Information, Management and Ethics, Karolinska Institutet, Stockholm, Sweden; Corresponding author at: Norra stationsgatan 99, 113 64 Stockholm, Sweden.Department of Learning, Information, Management and Ethics, Karolinska Institutet, Stockholm, SwedenSynergus AB, Stockholm, SwedenDepartment of Learning, Information, Management and Ethics, Karolinska Institutet, Stockholm, Sweden; Synergus AB, Stockholm, Sweden; Division of Epidemiology and Global Health, Department of Public Health and Clinical Medicine, Umeå University, Umeå, SwedenDepartment of Public Health Sciences, Karolinska Institutet, Stockholm, SwedenBackground: Heart failure represents a major public health issue that impacts 26 million people globally. Currently, real-world data represents a key instrument for providing the verification of both internal and external validity, yet there is still a lack of understanding regarding its scope in complementing evidence of treatments for heart failure. This study aims to increase understanding of the utilisation of real-word data from heart failure registries in Organisation for Economic Co-operation and Development (OECD) countries. Method: This was a systematic review of existing observational studies from heart failure registries in 35 OECD member countries. Studies from 2000 to March 2017 were identified through electronic databases (MEDLINE (Ovid), EMBASE, Web of Science Core Collection, CINAHL (Ebsco), Cochrane CENTRAL) and appraised according to eligibility criteria. Results: Two-hundred and two studies met the inclusion criteria, in which the majority were published from 2013 to 2016. All 202 studies were observational, among which 98% were cohort studies (198). The median sample size of all studies was 5152 (2417 to 32,890) and median study period 55 months (33.0 to 72.0). Swedish heart failure registry had the most publications (24, 12%). Conclusion: Since 2000 there has been an upward trend in the number of published observational studies on heart failure registries in OECD countries with increasingly diverse outcomes and advanced statistical methods to improve their validity and reliability. This indicates that the utilisation of real-world data has experienced a significant upsurge in complementing the findings of clinical trials for improved research of heart failure treatments. Keywords: Systematic review, Heart failure, Registry, Real-world data, Observational study, OECDhttp://www.sciencedirect.com/science/article/pii/S2352906718300149
spellingShingle Xiaoyang Du
Adina Khamitova
Mattias Kyhlstedt
Sun Sun
Mathilde Sengoelge
Utilisation of real-world data from heart failure registries in OECD countries - A systematic review
International Journal of Cardiology: Heart & Vasculature
title Utilisation of real-world data from heart failure registries in OECD countries - A systematic review
title_full Utilisation of real-world data from heart failure registries in OECD countries - A systematic review
title_fullStr Utilisation of real-world data from heart failure registries in OECD countries - A systematic review
title_full_unstemmed Utilisation of real-world data from heart failure registries in OECD countries - A systematic review
title_short Utilisation of real-world data from heart failure registries in OECD countries - A systematic review
title_sort utilisation of real world data from heart failure registries in oecd countries a systematic review
url http://www.sciencedirect.com/science/article/pii/S2352906718300149
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AT mattiaskyhlstedt utilisationofrealworlddatafromheartfailureregistriesinoecdcountriesasystematicreview
AT sunsun utilisationofrealworlddatafromheartfailureregistriesinoecdcountriesasystematicreview
AT mathildesengoelge utilisationofrealworlddatafromheartfailureregistriesinoecdcountriesasystematicreview