Family-Based Haplotype Estimation and Allele Dosage Correction for Polyploids Using Short Sequence Reads

Family-Based Haplotype Estimation and Allele Dosage Correction for Polyploids Using Short Sequence Reads

DNA sequence reads contain information about the genomic variants located on a single chromosome. By extracting and extending this information using the overlaps between the reads, the haplotypes of an individual can be obtained. Using parent-offspring relationships in a population can considerably...

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Bibliographic Details
Main Authors: Ehsan Motazedi, Chris Maliepaard, Richard Finkers, Richard Visser, Dick de Ridder
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Genetics
Subjects:
haplotype
polyploid
sequence data
family
estimation
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00335/full

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