Induction of Durable Antitumor Response by a Novel Oncolytic Herpesvirus Expressing Multiple Immunomodulatory Transgenes

Induction of Durable Antitumor Response by a Novel Oncolytic Herpesvirus Expressing Multiple Immunomodulatory Transgenes

Oncolytic virotherapy is a promising new tool for cancer treatment, but direct lytic destruction of tumor cells is not sufficient and must be accompanied by strong immune activation to elicit anti-tumor immunity. We report here the creation of a novel replication-competent recombinant oncolytic herp...

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Bibliographic Details
Main Authors: Dmitry V. Chouljenko, Jun Ding, I-Fang Lee, Yanal M. Murad, Xuexian Bu, Guoyu Liu, Zahid Delwar, Yi Sun, Sheng Yu, Ismael Samudio, Ronghua Zhao, William Wei-Guo Jia
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Biomedicines
Subjects:
immunotherapy
oncolytic virus
herpes simplex virus
cancer vaccine
antitumor immunity
combinatorial therapy
Online Access:https://www.mdpi.com/2227-9059/8/11/484

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