Cognitive impairment and neuropsychiatric symptoms among individuals with history of symptomatic SARS-CoV-2 infection: a retrospective longitudinal study
ABSTRACT. COVID-19 is a multisystem disease caused by the RNA virus (coronavirus 2 or SARS-CoV-2) that can impact cognitive measures. Objective: To identify the main cognitive and neuropsychiatric symptoms in adults who had no cognitive complaints prior to the infection. Specifically, to observe t...
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| Format: | Article |
| Language: | English |
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Associação Neurologia Cognitiva e do Comportamento
2024-02-01
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| Series: | Dementia & Neuropsychologia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642024000100301&tlng=en |
| _version_ | 1797302359011885056 |
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| author | Nariana Mattos Figueiredo Sousa Ana Claudia Paradella Freitas Maranhão Lucia Willadino Braga |
| author_facet | Nariana Mattos Figueiredo Sousa Ana Claudia Paradella Freitas Maranhão Lucia Willadino Braga |
| author_sort | Nariana Mattos Figueiredo Sousa |
| collection | DOAJ |
| description | ABSTRACT. COVID-19 is a multisystem disease caused by the RNA virus (coronavirus 2 or SARS-CoV-2) that can impact cognitive measures. Objective: To identify the main cognitive and neuropsychiatric symptoms in adults who had no cognitive complaints prior to the infection. Specifically, to observe the trajectory of cognitive and neuropsychiatric performance after 6 months. Methods: This is a retrospective longitudinal study. Forty-nine patients (29 reassessed after 6 months), with a positive PCR test, with no prior cognitive complaints that only presented after the infection and without a history of structural, neurodegenerative or psychiatric neurological diseases. A brief cognitive assessment battery (MoCA), the Trail Making Test (TMT-A, B, ∆), and the Verbal Fluency Test were used, as well as the scales (Hospital Anxiety and Depression Scale-HADS, Fatigue Severity Scale-FSS). Correlation tests and group comparison were used for descriptive and inferential statistics. Level of significance of α=5%. Results: Mean age of 50.4 (11.3), 12.7 (2.8) years of education, higher percentage of women (69.8%). No psycho-emotional improvement (depression and anxiety) was observed between the evaluations, and patients maintained the subjective complaint of cognitive changes. The HAD-Anxiety scale showed a significant correlation with TMT-B errors. The subgroup participating in cognitive stimulation and psychoeducation showed improvement in the global cognition measure and the executive attention test. Conclusion: Our results corroborate other studies that found that cognitive dysfunctions in post-COVID-19 patients can persist for months after disease remission, as well as psycho-emotional symptoms, even in individuals with mild infection. Future studies, with an increase in casuistry and control samples, are necessary for greater evidence of these results. |
| first_indexed | 2024-03-07T23:35:42Z |
| format | Article |
| id | doaj.art-a6d96634e5284b1b8a9e7869f598c3b8 |
| institution | Directory Open Access Journal |
| issn | 1980-5764 |
| language | English |
| last_indexed | 2024-03-07T23:35:42Z |
| publishDate | 2024-02-01 |
| publisher | Associação Neurologia Cognitiva e do Comportamento |
| record_format | Article |
| series | Dementia & Neuropsychologia |
| spelling | doaj.art-a6d96634e5284b1b8a9e7869f598c3b82024-02-20T07:36:11ZengAssociação Neurologia Cognitiva e do ComportamentoDementia & Neuropsychologia1980-57642024-02-011810.1590/1980-5764-dn-2023-0053Cognitive impairment and neuropsychiatric symptoms among individuals with history of symptomatic SARS-CoV-2 infection: a retrospective longitudinal studyNariana Mattos Figueiredo Sousahttps://orcid.org/0000-0001-7808-8020Ana Claudia Paradella Freitas Maranhãohttps://orcid.org/0000-0001-5485-7243Lucia Willadino Bragahttps://orcid.org/0000-0003-2985-8425ABSTRACT. COVID-19 is a multisystem disease caused by the RNA virus (coronavirus 2 or SARS-CoV-2) that can impact cognitive measures. Objective: To identify the main cognitive and neuropsychiatric symptoms in adults who had no cognitive complaints prior to the infection. Specifically, to observe the trajectory of cognitive and neuropsychiatric performance after 6 months. Methods: This is a retrospective longitudinal study. Forty-nine patients (29 reassessed after 6 months), with a positive PCR test, with no prior cognitive complaints that only presented after the infection and without a history of structural, neurodegenerative or psychiatric neurological diseases. A brief cognitive assessment battery (MoCA), the Trail Making Test (TMT-A, B, ∆), and the Verbal Fluency Test were used, as well as the scales (Hospital Anxiety and Depression Scale-HADS, Fatigue Severity Scale-FSS). Correlation tests and group comparison were used for descriptive and inferential statistics. Level of significance of α=5%. Results: Mean age of 50.4 (11.3), 12.7 (2.8) years of education, higher percentage of women (69.8%). No psycho-emotional improvement (depression and anxiety) was observed between the evaluations, and patients maintained the subjective complaint of cognitive changes. The HAD-Anxiety scale showed a significant correlation with TMT-B errors. The subgroup participating in cognitive stimulation and psychoeducation showed improvement in the global cognition measure and the executive attention test. Conclusion: Our results corroborate other studies that found that cognitive dysfunctions in post-COVID-19 patients can persist for months after disease remission, as well as psycho-emotional symptoms, even in individuals with mild infection. Future studies, with an increase in casuistry and control samples, are necessary for greater evidence of these results.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642024000100301&tlng=enCOVID-19SARS-CoV-2Cognitive DysfunctionLongitudinal Studies |
| spellingShingle | Nariana Mattos Figueiredo Sousa Ana Claudia Paradella Freitas Maranhão Lucia Willadino Braga Cognitive impairment and neuropsychiatric symptoms among individuals with history of symptomatic SARS-CoV-2 infection: a retrospective longitudinal study Dementia & Neuropsychologia COVID-19 SARS-CoV-2 Cognitive Dysfunction Longitudinal Studies |
| title | Cognitive impairment and neuropsychiatric symptoms among individuals with history of symptomatic SARS-CoV-2 infection: a retrospective longitudinal study |
| title_full | Cognitive impairment and neuropsychiatric symptoms among individuals with history of symptomatic SARS-CoV-2 infection: a retrospective longitudinal study |
| title_fullStr | Cognitive impairment and neuropsychiatric symptoms among individuals with history of symptomatic SARS-CoV-2 infection: a retrospective longitudinal study |
| title_full_unstemmed | Cognitive impairment and neuropsychiatric symptoms among individuals with history of symptomatic SARS-CoV-2 infection: a retrospective longitudinal study |
| title_short | Cognitive impairment and neuropsychiatric symptoms among individuals with history of symptomatic SARS-CoV-2 infection: a retrospective longitudinal study |
| title_sort | cognitive impairment and neuropsychiatric symptoms among individuals with history of symptomatic sars cov 2 infection a retrospective longitudinal study |
| topic | COVID-19 SARS-CoV-2 Cognitive Dysfunction Longitudinal Studies |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642024000100301&tlng=en |
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